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47 results for “Subjective cognitive decline”
Clinical and Biological Effects of Citrus-phytochemicals in Subjective Cognitive Decline.
ClinicalTrials.gov study NCT04744922. IPD Sharing: YES. Countries: 1. Publications: 15.
Long-term dietary flavonoid intake and subjective cognitive decline in US men and women
<p><b>Objective:</b> To prospectively examine the associations between long-term dietary flavonoids and subjective cognitive decline (SCD).</p> <p><b>Methods:</b><b> </b>We followed 49,493 women from the Nurses' Health Study (NHS) (1984-2006) and 27,842 men from the Health Professionals Follow-up Study (HPFS) (1986-2002). Poisson regression was used to evaluate the associations between dietary flavonoids (flavonols, flavones, flavanones, flavan-3-ols, anthocyanins, polymeric flavonoids, and proanthocyanidins) and subsequent SCD. For the NHS, long-term average dietary intake was calculated from seven repeated food frequency questionnaires (SFFQs), and SCD was assessed in 2012 and 2014. For the HPFS, average dietary intake was calculated from five repeated SFFQs, and SCD assessed in 2008 and 2012.</p> <p><b>Result</b><b>s: </b>Higher intake of total flavonoids was associated with lower odds of SCD after adjusting for age, total energy intake, major non-dietary factors, and specific dietary factors. Comparing the highest versus the lowest quintiles of total flavonoid intake, the pooled multivariable-adjusted odds ratios (ORs) (95% CIs) of 3-unit increments in SCD was 0.81 (0.76, 0.89). In the pooled results, the strongest associations were observed for flavones (OR=0.62 [0.57, 0.68]), flavanones (0.64 [0.58, 0.68)]), and anthocyanins (0.76 [0.72, 0.84]) (<i>p</i> trend <0.0001 for all groups). The dose-response curve was steepest for flavones, followed by anthocyanins. Many flavonoid-rich foods, such as strawberries, oranges, grapefruits, citrus juices, apples/pears, celery, peppers, and bananas, were significantly associated with lower odds of SCD.</p> <p><b>Conclusion: </b>Our findings support a benefit of higher flavonoid intakes for maintaining cognitive function in US men and women.<b> </b></p>
ATN-classification and clinical progression in subjective cognitive decline: the SCIENCe project
<p>Objective: To investigate the relationship between the ATN-model and risk of dementia and cognitive decline in individuals with subjective cognitive decline (SCD).</p> <p>Methods: We classified 693 participants with SCD (60±9yr, 41%F, MMSE 28±2) from the Amsterdam Dementia Cohort and SCIENCe project according to the ATN-model, as determined by amyloid PET or CSF Abeta (A), CSF p-tau (T) and MRI-based medial temporal lobe atrophy (N). All underwent extensive neuropsychological assessment. For 342 participants follow-up was available (3±2yr). As a control population, we included 124 participants without SCD.</p> <p>Results: 56% (n=385) participants had <i>normal AD biomarkers </i>(A-T-N-), 27% (n=186) had <i>non-AD pathologic change</i> (A-T-N+, A-T+N-, A-T+N+), 18% (n=122) fell within the <i>Alzheimer's continuum </i>(A+T-N-, A+T-N+, A+T+N-, A+T+N+). ATN profiles were unevenly distributed, with A-T+N+, A+T-N+ and A+T+N+ containing very few participants. Cox regression showed that compared to A-T-N-, participants in A+ profiles had a higher risk of dementia with a dose-response pattern for number of biomarkers affected. Linear mixed models showed participants in A+ profiles showed a steeper decline on tests addressing memory, attention, language, and executive functions. In the control group, there was no association between ATN and cognition.</p> <p>Conclusions: Among individuals presenting with SCD at a memory clinic, those with a biomarker profile A-T+N+, A+T-N-, A+T+N- and A+T+N+ were at increased risk of dementia, and showed steeper cognitive decline compared to A-T-N- individuals. These results suggest a future where biomarker results could be used for individualized risk profiling in cognitively normal individuals presenting at a memory clinic.</p>
Brain Health Program for Older Adults With Subjective Cognitive Decline
ClinicalTrials.gov study NCT05934136. IPD Sharing: NO. Countries: 1. Publications: 4.
REducing the Risk of COgnitive DEcline ad Dementia in Patients With Subjective Cognitive Decline Through an Immersive Virtual Reality and Telemedicine-based Multi-component Intervention: the SCD-ReCOD
ClinicalTrials.gov study NCT06429215. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sleep Apnea, Neurocognitive Decline and Brain Imaging in Patients With Subjective or Mild Cognitive Impairment
ClinicalTrials.gov study NCT06150352. IPD Sharing: UNDECIDED. Countries: 1. Publications: 8.
Polyamine-enriched Diet in Healthy Older Adults With Subjective Cognitive Decline
ClinicalTrials.gov study NCT02755246. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Effect of Hearing Loss and Vestibular Decline on Cognitive Function in Older Subjects
ClinicalTrials.gov study NCT04385225. IPD Sharing: NO. Countries: 1. Publications: 1.
Impact of a Cognitive Intervention Enriched With Leisure Activities in Persons With Subjective Cognitive Decline
ClinicalTrials.gov study NCT03271190. IPD Sharing: NO. Countries: 1. Publications: 1.
Polyamine-enriched Diet in Elderly Individuals With Subjective Cognitive Decline
ClinicalTrials.gov study NCT03094546. IPD Sharing: UNDECIDED. Countries: 1. Publications: 10.
PRedicting the EVolution of SubjectIvE Cognitive Decline to Alzheimer's Disease With Machine Learning
ClinicalTrials.gov study NCT05569083. IPD Sharing: UNDECIDED. Countries: 1. Publications: 14.
Italian Adaptation and Validation of Functional and Behavioural Scales for Subjective Cognitive Decline, Mild Cognitive Impairment and Mild Dementia.
ClinicalTrials.gov study NCT06701630. IPD Sharing: UNDECIDED. Countries: 1. Publications: 15.
Testing the Cog-Fun Aging Program for Older Adults With Subjective Cognitive Decline
ClinicalTrials.gov study NCT06816797. IPD Sharing: NO. Countries: 1. Publications: 4.
Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention
ClinicalTrials.gov study NCT03978052. IPD Sharing: Not stated. Countries: 1. Publications: 22.
Community-based Cohort of Functional Decline in Subjective Cognitive Complaint Elderly
ClinicalTrials.gov study NCT04265482. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Effects Of An 8-Weeks Mindfulness-based Intervention In Individuals With Subjective Cognitive Decline
ClinicalTrials.gov study NCT03005652. IPD Sharing: NO. Countries: 4. Publications: 7.
The Efficacy and Mechanism of Acupuncture Treatment in Patients With Subjective Cognitive Decline
ClinicalTrials.gov study NCT03444896. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Cognitive Intervention With Go and Chess in Early and Subjective Cognitive Decline
ClinicalTrials.gov study NCT06281652. IPD Sharing: NO. Countries: 1. Publications: 1.
ATN-classification and clinical progression in subjective cognitive decline: the SCIENCe project
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Long-term dietary flavonoid intake and subjective cognitive decline in US men and women
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.