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5 results for “Sulfoximine”
Neonicotinoid and sulfoximine pesticides differentially impair insect escape behaviour and motion detection
<p><span><span><span><span><span><span><span><span><span><span><span>Insect nervous systems offer unique advantages for studying interactions between sensory systems and behaviour given that they are complex and yet highly tractable. By examining the neural coding of salient environmental stimuli and resulting behavioural output in the context of environmental stressors, we gain an understanding of the effects of these stressors on brain and behaviour and provide insight into normal function. The implication of neonicotinoid (neonic) pesticides in contributing to declines of non-target species, such as bees, has motivated development of new compounds, which could potentially mitigate putative resistance in target species (1, 2) and declines of non-target species. We used a neuroethological approach, including behavioural assays and multineuronal recording techniques, to investigate effects of imidacloprid and the novel insecticide sulfoxaflor on visual motion-detection circuits and related escape behaviour in the tractable locust system. Despite similar LD50 values, imidacloprid and sulfoxaflor evoked different behavioural and physiological effects. Imidacloprid significantly attenuated collision avoidance behaviours and impaired responses of neural populations, including a decrease in spontaneous firing and decreased neural habituation. In contrast, sulfoxaflor displayed no effect at a comparable sublethal dose. These are the first results to show that a neonic affects population responses and habituation of a visual motion detection system. We propose that differences in the sublethal effects of sulfoxaflor reflect an altered mode of action to imidacloprid. More broadly, we suggest that neuroethological assays for comparative neurotoxicology are a valuable tool to fully address current issues regarding proximal effects of environmental toxicity in non-target species.</span></span></span></span></span></span></span></span></span></span></span></p>
N99-02: Melphalan and Buthionine Sulfoximine
ClinicalTrials.gov study NCT00005835. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Neonicotinoid and sulfoximine pesticides differentially impair insect escape behaviour and motion detection
Open the record for dataset details and reuse information.
Planarizable Push-Pull Probes with Sulfoximine-Bridged Dithienothiophene Acceptors
<p>Original data</p>
A Phase I Trial of Normothermic Isolated Limb Infusion (ILI) With Melphalan Plus Buthionine Sulfoximine (BSO) in Patients With Locally Advanced Malignant Melanoma
ClinicalTrials.gov study NCT00661336. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.