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ShareScore release 0.9.0
Dataset results
9 results for “Synaptic inhibition”
Data Set related to Synaptic inhibition in the lateral habenula shapes reward anticipation.
<p>The lateral habenula (LHb) supports learning processes enabling the prediction of upcoming rewards. While reward-related stimuli decrease the activity of LHb neurons, whether this anchors on synaptic inhibition to guide reward-driven behaviors remains poorly understood. Here, we combine in vivo two-photon calcium imaging with Pavlovian conditioning in mice and report that anticipatory licking emerges along with decreases in cue-evoked calcium signals in individual LHb neurons. In vivo multiunit recordings and pharmacology reveal that the cue-evoked reduction in LHb neuronal firing relies on GABA<sub>A</sub>-receptor activation. In parallel, we observe a postsynaptic potentiation of GABA<sub>A</sub>-receptor-mediated inhibition, but not excitation, onto LHb neurons together with the establishment of anticipatory licking. Finally, strengthening or weakening postsynaptic inhibition with optogenetics and GABA<sub>A</sub>-receptor manipulations enhances or reduces anticipatory licking, respectively. Hence, synaptic inhibition in the LHb shapes reward anticipation.</p>
Leukotriene A4 hydrolase inhibition improves age related cognitive decline via modulation of synaptic function (Part 2/2)
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Leukotriene A4 hydrolase inhibition improves age related cognitive decline via modulation of synaptic function (Part 1/2)
Open the record for dataset details and reuse information.
SCD inhibition reverses immune, synaptic and behavioral deficits in an animal model of Alzheimer’s disease [bulk RNA-Seq]
GEO Series GSE167601. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
SCD inhibition reverses immune, synaptic and behavioral deficits in an animal model of Alzheimer’s disease [scRNA-Seq]
GEO Series GSE167600. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
SCD inhibition reverses immune, synaptic and behavioral deficits in an animal model of Alzheimer’s disease
GEO Series GSE167605. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Partial inhibition of mitochondrial complex I attenuates neurodegeneration and restores energy homeostasis and synaptic function in a symptomatic Alzheimer’s mouse model
GEO Series GSE149248. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease
GEO Series GSE125850. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Urolithin A mitigates behavioral and synaptic deficits associated with epilepsy through VDAC-1 inhibition: A novel treatment approach
GEO Series GSE263560. Drosophila melanogaster. 8 samples. Type: Expression profiling by high throughput sequencing.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.