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35 results for “Syndecan”
Effect of Sepsis Adsorption Column on Syndecan-1 and Mortality
ClinicalTrials.gov study NCT07033910. IPD Sharing: YES. Countries: 1. Publications: 21.
Data from: Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers
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Endothelial Damage in Major Spine Surgery, Measured by Circulating Syndecan-1: an Observational Study.(GlycOrtho)
ClinicalTrials.gov study NCT06119542. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
The Effect of Lower Intraabdominal Pressure on Syndecan-1, sVEGF-R2, Occludin, KIM-1, and IL-6 on Living Donor Laparoscopic Nephrectomy
ClinicalTrials.gov study NCT03219398. IPD Sharing: UNDECIDED. Countries: 1. Publications: 113.
Syndecan 1 as Biomarker for Inflammation
ClinicalTrials.gov study NCT02333526. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery
ClinicalTrials.gov study NCT02756715. IPD Sharing: NO. Countries: 1. Publications: 1.
Syndecan-1 a Surrogate Marker for IBD
ClinicalTrials.gov study NCT01430039. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Data from: The extracellular and cytoplasmic domains of Syndecan cooperate postsynaptically to promote synapse growth at the Drosophila neuromuscular junction
The heparan sulfate proteoglycan (HSPG) Syndecan (Sdc) is a crucial regulator of synapse development and growth in both vertebrates and invertebrates. In Drosophila, Sdc binds via its extracellular heparan sulfate (HS) sidechains to the receptor protein tyrosine phosphatase LAR to promote the morphological growth of the neuromuscular junction (NMJ). To date, however, little else is known about the molecular mechanisms by which Sdc functions to promote synapse growth. Here we show that all detectable Sdc found at the NMJ is provided by the muscle, strongly suggesting a post-synaptic role for Sdc. We also show that both the cytoplasmic and extracellular domains of Sdc are required to promote synapse growth or to rescue Sdc loss of function. We report the results of a yeast two-hybrid screen using the cytoplasmic domains of Sdc as bait, and identify several novel candidate binding partners for the cytoplasmic domains of Sdc. Together, these studies provide new insight into the mechanism of Sdc function at the NMJ, and provide enticing future directions for further exploring how Sdc promotes synapse growth.
Syndecan-4 proteoglycan modulates glucose uptake and insulin sensitivity in myoblasts
<p>Skeletal muscle glucose uptake is required for cellular metabolism and normalization of postprandial blood glucose levels. Transmembrane heparan sulfate proteoglycan syndecan-4 (SDC4) is important for muscle regeneration, cell interaction and structure, and it affects whole body metabolism, although the mechanism remains unclear. In this study, we demonstrated that SDC4 knock down increases glucose uptake by mammalian myoblasts (i.e., activated satellite cells). Silencing SDC4 increased the phosphorylation AS160 (Akt substrate of 160 kDa or TBC1D4), an important element of glucose transporter type 4 (GLUT4) translocation, and GLUT4 levels. These changes increased 2–deoxy-2–(<sup>18</sup>F)fluoro-D-glucose uptake by C2C12 myoblasts independent of insulin treatment. Mitochondrial routine respiration, electron transport system, reserve capacity, and oxidative phosphorylation were also increased following SDC4 silencing. SDC4 knockdown cells exhibited a higher GLUT4 density along the plasma membrane compared with behind it. Super-resolution direct stochastic optical reconstruction microscopy (dSTORM) imaging revealed an increased number of skeletons of the actin network following insulin treatment, but not in SDC4-silenced cells. Notably, knocking down SDC4 increased the insulin sensitivity of the cells. Our results suggest that this new mechanism can increase glucose uptake through insulin-independent signal transduction.</p> <p>Proteomics data.</p>
Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1
ClinicalTrials.gov study NCT04718623. IPD Sharing: Not stated. Countries: 0. Publications: 36.
The Effect of Sodium on Erythrocyte Salt Sensitivity, Syndecan-1 and Heparin Sulfate in Healthy Subjects.
ClinicalTrials.gov study NCT06968182. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Data from: The extracellular and cytoplasmic domains of Syndecan cooperate postsynaptically to promote synapse growth at the Drosophila neuromuscular junction
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Data from: Diagnostic and prognostic value of soluble syndecan-1 for pleural malignancies
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Syndecan-1-targeted therapeutic antibody inhibits macropinocytosis and induces antitumor immunity in pancreatic cancer
GEO Series GSE311267. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Syndecan-3 positively regulates the pro-inflammatory function of macrophages
GEO Series GSE273450. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
VISTA is an activating receptor that binds the proteoglycan Syndecan-2 on monocytes.
GEO Series GSE173747. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Other.
Syndecan-1 inhibition promotes anti-tumor immune response and facilitates the efficacy of anti-PD1 checkpoint immunotherapy [kdSdc1_scRNAseq]
GEO Series GSE231356. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Modulation of Syndecan-1/4 reduces the invasive potential of endometrioma through TGF-β signalling
GEO Series GSE135122. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
Dynamic interplay between sortilin and syndecan-1 has a role in the metabolic switch during prostate cancer progression
GEO Series GSE220618. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes [EKVX]
GEO Series GSE106303. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.