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8 results for “Synthetic gene circuits”
Multidimensional control of therapeutic human cell function with synthetic gene circuits
<p>Synthetic gene circuits that precisely control human cell function could expand the capabilities of gene and cell-based therapies. However, platforms for developing circuits in primary human cells that drive robust functional changes in vivo and have compositions suitable for clinical use are lacking. Here, we develop synthetic transcriptional regulators that are compact and based largely on human-derived proteins (synZiFTRs). As a proof of principle, we engineer gene switches and circuits that allow precise, user-defined control over therapeutically-relevant genes in primary T cells using orthogonal, FDA-approved small molecule inducers. Our circuits can instruct T cells to sequentially activate multiple cellular programs, such as proliferation and anti-tumor activity, to drive synergistic therapeutic responses. This platform should accelerate development and clinical translation of synthetic gene circuits in diverse human cell types and contexts.</p>
Multidimensional control of therapeutic human cell function with synthetic gene circuits
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Data - Synthetic mammalian RNA-based gene circuits for high fold change expression
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Identification of Sclareol As a Natural Neuroprotective Cav1.3-Antagonist Using Synthetic Parkinson-Mimetic Gene Circuits and Computer-Aided Drug Discovery
<p>Data underlying the figures in the publication “Identification of Sclareol As a Natural Neuroprotective Ca<sub>v</sub>1.3-Antagonist Using Synthetic Parkinson-Mimetic Gene Circuits and Computer-Aided Drug Discovery”, published in <em>Adv. Sci.,</em> <strong>2022</strong>, 9, 2102855.</p> <p><a href="https://doi.org/10.1002/advs.202102855">https://doi.org/10.1002/advs.202102855</a></p> <p>Table of contents:</p> <p><strong>1. Figure 1-3.xlsx</strong>: Source data for <em>Figures 1-3</em>.</p> <p><strong>2. Figure 4-5</strong>: Source data for <em>Figures 4-5</em>.</p> <p><strong>3. Figure1-3.zip</strong>: .zip archive containing the raw data of <em>Figures 1-3 </em>in <em>.pzfx</em> format.</p> <p><strong>4. Movie S1,2</strong>: Movie s1 and S2.</p>
A customized synthetic gene circuit selectively engages an immune-related transcriptional program in p53-negative LLC cells
GEO Series GSE179814. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Scalable dynamic characterization of synthetic gene circuits - Data
<p>This dataset contains supporting information and data for the preprint: <a href="https://www.biorxiv.org/content/10.1101/635672v2.abstract">Scalable dynamic characterization of synthetic gene circuits</a>.</p> <p>The dataset contains the following 3 files:</p> <ul> <li>DynamicCharacterizationGenbanks.zip: This zip contains Genbank files that describe the sequence information of the genetic circuits that have been built and characterized in this manuscript. </li> <li>DynamicCharacterizationWrapper.zip: This zip contains the models and data files of the case studies that run using the Dynamic Characterization wrapper CLI tool. </li> <li>GECWebserver.zip: This zip contains the models and data files of the case studies that run using the GEC (Genetic Engineering of Cells) Web server tool.</li> </ul>
A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues
GEO Series GSE165027. Sus scrofa. 54 samples. Type: Expression profiling by array.
A synthetic gene-metabolic circuit preferentially increased fatty acid metabolism in human hepatocytes
GEO Series GSE5903. Homo sapiens. 4 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.