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Dataset results
145 results for “T-cell receptor”
Control T-cell receptor (TCR) alpha and beta chain nucleotide and amino acid sequences from human and mouse
<p>A dataset of pooled T-cell receptor (TCR) sequences for TCR alpha and beta chains of human and mouse.</p> <p>Sequences are obtained from various samples of healthy individuals/mice using our conventional protocols: see for example [Britanova et al "Dynamics of individual T cell repertoires: from cord blood to centenarians" The Journal of Immunology 2016] and [Izraelson et al. "Comparative analysis of murine T‐cell receptor repertoires." Immunology 2018].</p> <p>The sequences are stored as gzipped clonotype tables in VDJtools format, see [https://vdjtools-doc.readthedocs.io/en/master/input.html#vdjtools-format].</p> <p>This control dataset can be used as a proxy for a generative VDJ rearrangement model to estimate the expected frequency distribution of TCRs and check for enrichment of rare TCR clonotypes and groups of similar TCR sequences. For the implementation of the enrichment analysis, please see CalcDegreeStats routine from VDJtools software, see [https://vdjtools-doc.readthedocs.io/en/master/annotate.html#calcdegreestats].</p> <p>Files named "human.tra.strict.txt.gz", etc are pools of random/naive TCR clonotypes containing unique V/J/CDR3 nucleotide sequence combinations observed in data. The pools.zip file is used for TCR motif inference in VDJdb database [https://github.com/antigenomics/vdjdb-motifs], it contains human.tra.aa.txt, etc files that contain random/naive TCR clonotypes grouped by CDR3 amino acid sequence with the most frequent representative V and J.</p>
Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodies
<p>Supporting datasets for preprint version of "Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodies".</p>
Enhancing comparative T-cell receptor repertoire analysis in small biological samples through pooling homologous cell samples from multiple mice
<p>All data files used to generate the figures in the paper are shared in this project.</p> <p>Scripts are available on <a href="https://github.com/i3-unit/CRM_24" target="_blank" rel="noopener">GitHub</a>.</p>
T-cell receptor Vβ (TCRVB) deep sequencing on human T cells isolated from humanized mice engrafted with human PBMC and treated or not with PTCy post-transplantation
<p>Nucleotide sequence data of TCRVB sequencing performed on T cells isolated from the pre-transplantation hPBMC (donor T cells) or from mice organs at day 21 post-transplantation (injected or not with PTCy at day 3) to determine the impact of PTCy on the T cell V beta (TCRVB) receptor repertoire diversity.</p> <p>NSG mice were engrafted with human PBMC to develop xeno-GVHD and treated or not with 100 mg/kg PTCy. Spleens and lungs from 10 NSG mice per group were pooled and stained to sorted human CD4+ and CD8+ . DNA of human CD4+ and CD8+ T cells sorted from each organ and from the PBMC donor was extracted. One hundred fifty µg from each sample were used for T-cell receptor Vβ (TCRVB) deep sequencing performed by Adaptive Biotechnologies.<br> </p>
Phase I/II Study of Autologous T Cells to Express T-Cell Receptors (TCRs) in Subjects With Solid Tumors
ClinicalTrials.gov study NCT05194735. IPD Sharing: NO. Countries: 1. Publications: 1.
Genetically Engineered Cells (MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells) and Atezolizumab for the Treatment of Metastatic Triple Negative Breast Cancer, Urothelial Cancer, or Non-
ClinicalTrials.gov study NCT04639245. IPD Sharing: NO. Countries: 1. Publications: 1.
T-cell Receptor α/β Depleted Donor Lymphocyte Infusion
ClinicalTrials.gov study NCT05350163. IPD Sharing: NO. Countries: 1. Publications: 31.
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients
ClinicalTrials.gov study NCT03745326. IPD Sharing: YES. Countries: 1. Publications: 3.
TCRBuilder2+ predictions of the Observed T-cell receptor Space (OTS)
<p>TCRBuilder2+ predictions of over 1.5 million TCR structures from the Observed T-cell receptor Space database. </p>
Supplemental Data: Differential roles of kinetic on- and off-rates in T-cell receptor signal integration revealed with a modified Fab'-DNA ligand
<p>Microscopy data and associated code for analysis. For more information refer to https://doi.org/10.1101/2024.04.01.587588.</p>
ALLoreactive T-Cell receptOr RePertoire in kidnEy tranSplantation
ClinicalTrials.gov study NCT03422224. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell ( CAR-T) Therapy in Subjects With Non-relapsing and Progressive Forms of Multiple Sclerosis
ClinicalTrials.gov study NCT06138132. IPD Sharing: NO. Countries: 1. Publications: 3.
Senl_1904A and Senl_1904B Chimeric Antigen Receptor （CAR） T-Cell in the Treatment of r/ r Acute B Lymphocytic Leukemia
ClinicalTrials.gov study NCT03840317. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Treatment of Relapsed or Refractory B-cell Lymphoma With Chimeric Antigen Receptor (CAR) T-cell Therapy Produced by a New Technology
ClinicalTrials.gov study NCT06378190. IPD Sharing: YES. Countries: 1. Publications: 1.
Hypoxia-Specific Imaging to Predict Outcomes of Chimeric Antigen Receptor T-cell Therapy
ClinicalTrials.gov study NCT04409314. IPD Sharing: NO. Countries: 1. Publications: 1.
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
ClinicalTrials.gov study NCT03190941. IPD Sharing: YES. Countries: 1. Publications: 3.
Phase 1/2 Study of Metastatic Renal Cancer Using T-Cells Transduced With a T-Cell Receptor Which Recognizes TRAIL Bound to the DR4 Receptor
ClinicalTrials.gov study NCT00923390. IPD Sharing: Not stated. Countries: 1. Publications: 3.
E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers
ClinicalTrials.gov study NCT05639972. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study of LCAR-B38M CAR-T Cells, a Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Chinese Participants With Relapsed or Refractory Multiple Myel
ClinicalTrials.gov study NCT03758417. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety Study of Chimeric Antigen Receptor Modified T-cells Targeting NKG2D-Ligands
ClinicalTrials.gov study NCT02203825. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.