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85 results for “T-lymphocytes”
Raw data related to: Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)
<p><strong>Abstract</strong></p> <p>Fatty liver disease is a serious complication of childhood obesity. Calorie-restricted regimen (RCR) is one of the e ective therapy for this condition. Aim of the study was to evaluate the effect of lycopene-rich tomato sauce with oregano and basil extracts in obese children with fatty liver on RCR. 61 obese children with fatty liver were enrolled, 52 completed the study. A randomized cross over clinical trial was performed. Participants were assigned to RCR alone or with a supplement of lycopene-rich tomato juice for 60 days; subsequently, the groups were switched to the alternative regimen for the next 60 days. Reduction in BMI, HOMA-IR, cholesterol, triglycerides, liver size, and steatosis was more profound in tomato-supplemented group. Leptin decreased in both groups whereas adiponectin raised only after tomato supplementation. RCR is associated with the impaired engagement of T-cells glycolysis and proliferation, tomato-supplementation resulted in glycolytic metabolic activation of T-cells. Tomato juice ameliorates glucose and lipid metabolism in obese children, improve oxidative and inflammatory state and modulates the mitochondrial metabolism of T-cells contributing to a maintenance of a proper immune surveillance in children, impaired by RCR. The addition of tomato to RCR could be considered a protective and preventive support to obese child.</p> <p><strong>Progetto giovani ricercatori </strong>[GR-2016-02363725] dal titolo: "Immune Tolerance, Metabolism and Multiple Sclerosis: Novel Molecular Tools to Monitor Disease Pathogenesis and Progression"</p>
Evaluate the Efficacy and Safety of Activated T-lymphocyte Cell Therapy in Advanced Pancreatic Cancer
ClinicalTrials.gov study NCT00965718. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Therapeutic Effects of Epstein-Barr Virus Immune T-Lymphocytes Derived From a Normal HLA-Compatible Or Partially-Matched Third-Party Donor in the Treatment of EBV Lymphoproliferative Disorders and EBV
ClinicalTrials.gov study NCT01498484. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase II/III Study Evaluating the Effect of IL-2 on Preservation of the CD4 T-Lymphocytes After Interruption of Antiretroviral Treatment in HIV-Infected Patients With CD4 T-Lymphocyte Count Greater Th
ClinicalTrials.gov study NCT00071890. IPD Sharing: Not stated. Countries: 2. Publications: 4.
Pan-Tumor T-Lymphocyte Detection Dataset
<p>This is a pan-tumor immunohistochemistry dataset containing 2 mm<sup>2</sup>-sized regions of interest (ROIs) from 92 whole slide images stained for cluster of differentiation 3 (CD3, antibody clone SP7). The dataset covers four tumor indications:</p> <ul> <li>32 head and neck squamous cell carcinoma (HNSCC) samples</li> <li>20 non-small cell lung cancer (NSCLC) samples</li> <li>20 triple-negative breast cancer (TNBC) samples</li> <li>20 gastric cancer (GC) samples</li> </ul> <p>The samples were digitized at a resolution of 0.23 μm/px (40× objective lens) using the NanoZoomer 2.0-HT scanning system (Hamamatsu, Japan). All samples were prepared and digitized at Merck Healthcare KGaA.</p> <p>We provide bounding box annotations for three cell types: CD3+ immune cells, tumor cells, and other cells. For each tumor indication, five ROIs were manually annotated by three pathologists. For these ROIs, we provide all three annotations and the consensus of all raters. All other ROIs have been semi-automatically annotated using commercial image analysis software. </p>
T-Lymphocytes Genetically Targeted to the B-Cell Specific Antigen CD19 in Pediatric and Young Adult Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia
ClinicalTrials.gov study NCT01860937. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Safety and Efficacy of Abatacept for Treating Chronic Cytopenia in Cytotoxic T-Lymphocyte Antigen 4 (CTLA4) Haploinsufficiency
ClinicalTrials.gov study NCT03733067. IPD Sharing: NO. Countries: 1. Publications: 3.
In Vitro Expanded Allogeneic Epstein-Barr Virus Specific Cytotoxic T-Lymphocytes (EBV-CTLs) Genetically Targeted to the CD19 Antigen in B-cell Malignancies
ClinicalTrials.gov study NCT01430390. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cytotoxic T-Lymphocytes for EBV-positive Lymphoma, GRALE
ClinicalTrials.gov study NCT01555892. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Administration of Rapidly Generated Multivirus-specific Cytotoxic T-Lymphocytes (VIRAGE)
ClinicalTrials.gov study NCT01070797. IPD Sharing: Not stated. Countries: 1. Publications: 1.
T-Lymphocytes for Prevention or Treatment of Viral Infections Following Hematopoietic Stem Cell Transplantation
ClinicalTrials.gov study NCT03180216. IPD Sharing: YES. Countries: 1. Publications: 1.
Most Closely HLA Matched Allogeneic Virus Specific Cytotoxic T-Lymphocytes (CTL)
ClinicalTrials.gov study NCT00711035. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Determination of Dosing and Frequency of BCG Administration to Alter T-Lymphocyte Profiles in Type I Diabetics
ClinicalTrials.gov study NCT00607230. IPD Sharing: Not stated. Countries: 1. Publications: 1.
EBV Specific T-Lymphocytes for Treatment of EBV-Positive Lymphoma
ClinicalTrials.gov study NCT04664179. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Cytotoxic T-Lymphocytes for the Prophylaxis of Cytomegalovirus After Allogeneic Stem Cell Transplant
ClinicalTrials.gov study NCT00078533. IPD Sharing: Not stated. Countries: 1. Publications: 2.
T-Lymphocytes in Treating Patients With Epstein-Barr Virus-Positive Nasopharyngeal Cancer, NPC
ClinicalTrials.gov study NCT00609219. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Allogeneic Epstein Barr Virus-Specific Cytotoxic T-Lymphocytes in Treating Patients With Progressive, Relapsed, or Refractory Hodgkin's Lymphoma
ClinicalTrials.gov study NCT00006100. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impact of Anti-Tumor Necrosis Factor (TNF) Antibodies on the T-lymphocyte and Macrophage Cooperation in Crohn Disease
ClinicalTrials.gov study NCT00561548. IPD Sharing: Not stated. Countries: 1. Publications: 19.
Administration of Virus-Specific Cytotoxic T-Lymphocytes
ClinicalTrials.gov study NCT00590083. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vopratelimab (JTX-2011) Alone and in Combination With Anti-Programmed Cell Death Protein 1 (PD-1) or Anti-Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) in Subjects With Advanced and/or Refractory Solid Tu
ClinicalTrials.gov study NCT04319224. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.