Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
10
datasets available to search
ShareScore release 0.9.0
Dataset results
10 results for “TARDBP”
Integrated profiling of iPSC-derived motor neurons carrying C9orf72, FUS, TARDBP, or SOD1 mutations
GEO Series GSE299997. Homo sapiens. 156 samples. Type: Expression profiling by high throughput sequencing.
RNA sequencing of motor neurons derived from induced pluripotent stem cells of ALS patients with the M337V mutation in TARDBP
GEO Series GSE147544. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis on TDP-43 downstream genes in Tardbp KO mice by Next Generation Sequencing
GEO Series GSE116456. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA sequencing of spinal motor neurons and interneurons differentiated from isogenic FUS and TARDBP human induced pluripotent stem cell lines harbouring ALS-causative mutations
GEO Series GSE226482. Homo sapiens. 1415 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile of TARDBP in hepatocellular carcinoma cell line (SK-Hep1)
GEO Series GSE37640. Homo sapiens. 6 samples. Type: Expression profiling by array.
Deletion of Tardbp Down-Regulates Tbc1d1, a Gene Linked to Obesity, and Alters Body Fat Metabolism
GEO Series GSE21993. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Personalized Antisense Oligonucleotide Therapy for A Single Participant With TARDBP ALS
ClinicalTrials.gov study NCT07095712. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data and code for TARDBP exitron splicing paper
<p>Takuma Yamagishi1), Shingo Koide1), Genri Toyama1), Aya Washida1), Yumi Yamada1), Ryutaro Hanyu1), Ekaterina Nadbitova1), Yuka Mitsuhashi Koike2), Takuya Konno1), Tomohiko Ishihara1), Taisuke Kato2), Osamu Onodera1) 2), Akihiro Sugai1)</p> <p>1)Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute, Niigata University, Niigata, Japan.</p> <p>2)Department of Molecular Neuroscience, Resource Branch for Brain Disease Research, Brain Research Institute, Niigata University, Niigata, Japan. </p> <p> </p> <p>This repository contains data, analysis code, supplementary materials, and original uncropped blot images for the paper "Exitron splicing breaks TDP-43 aggregation-dysfunction spiral in ALS and FTLD".</p> <p>Contents:</p> <ol> <li>Data: <ul> <li>Raw data files used in the analyses (CSV format)</li> <li>All data is contained in a single file named 'data.zip'</li> <li>The ZIP file structure: <ul> <li>Separate folders for Figure 1 to Figure 5, and Supplementary Figure S1 to Supplementary Figure S9</li> <li>Each folder contains the corresponding CSV files used for that specific figure</li> </ul> </li> <li>Processed data files directly used in figure generation (Excel format)</li> </ul> </li> <li>Analysis Code: <ul> <li>R Markdown (Rmd) files containing the complete analysis pipeline</li> <li>These files include code for data processing, statistical analyses, and figure generation</li> <li>Each section in the Rmd files corresponds to a specific figure in the main manuscript</li> </ul> </li> <li>Output: <ul> <li>PDF files generated from knitting the Rmd documents</li> <li>These PDFs provide a readable format of the code along with its output</li> </ul> </li> <li>Original Blot Images: <ul> <li>Uncropped, full-length images of all blots used in the study</li> <li>These images are provided to ensure full transparency and to allow for independent verification of our results</li> </ul> </li> </ol> <p>The R Markdown documents are organized by figure numbers as they appear in the main manuscript. They contain detailed R code that reproduces all analyses and generates the figures presented in the paper. The code utilizes various R packages for data manipulation, statistical analysis, and visualization.</p> <p>To use this code:</p> <ol> <li>Ensure all necessary R packages are installed</li> <li>Verify that the data files are in the correct directory structure as indicated in the code</li> <li>Run the R Markdown documents in the order presented</li> </ol> <p>The inclusion of original, uncropped blot images allows for a complete assessment of the experimental data. These images are provided in their raw format, as captured by the imaging equipment, without any post-processing or cropping.</p> <p>Note that while these materials allow for the reproduction of our analyses, readers should refer to the main manuscript for comprehensive interpretation of the results and their biological significance.</p> <p>We encourage other researchers to use these resources for verification of our results or as a starting point for further investigations in the field of TDP-43 proteinopathies and TARDBP exitron splicing.</p> <p>For any questions or issues regarding this data, code, or original images, please contact the corresponding author.</p> <p>This work is licensed under CC BY 4.0. When using this data/code, please cite our paper.</p>
Downstream Effects of Mutations in SOD1 and TARDBP Converge on Gene Expression Impairment in Patient-Derived Motor Neurons
GEO Series GSE210969. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Precise RNA knockdown of smn1,or tardbp and tarbpl by CRISPR-QKD and transcription activation of lin28a and sox9b by CRISPR-Qa in zebrafish
GEO Series GSE268371. Danio rerio. 24 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.