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122 results for “TARP”
TARP 2019: SU 1044, SU 1060
Photogrammetric capture (sparse cloud) of stratigraphic units 1044, 1060 Source: Objaverse 1.0 / Sketchfab
TARP 2019: SU 2048 - SU 2051
Photogrammetric capture of stratigraphic units 2048, 2049, 2050, and 2051. Source: Objaverse 1.0 / Sketchfab
Distinct roles of the Chlamydia trachomatis effectors TarP and TmeA in the regulation of formin and Arp2/3 during entry
<p>The obligate intracellular pathogen Chlamydia trachomatis manipulates the host actin cytoskeleton to assemble actin-rich structures that drive pathogen entry. The recent discovery of TmeA, which, like TarP, is an invasion-associated type III effector implicated in actin remodeling, raised questions regarding the nature of their functional interaction. Quantitative live-cell imaging of actin remodeling at invasion sites revealed differences in recruitment and turnover kinetics associated with the TarP and TmeA pathways, with the former accounting for most of the robust actin dynamics at invasion sites. TarP-mediated recruitment of actin nucleators, i.e. formins and the Arp2/3 complex, was crucial for rapid actin kinetics, generating a collaborative positive feedback loop that enhanced their respective actin-nucleating activities within invasion sites. In contrast, the formin Fmn1 was not recruited to invasion sites and did not collaborate with Arp2/3 within the context of Tme-aassociated actin recruitment. Although the TarP-Fmn1-Arp2/3 signaling axis is responsible for the majority of actin dynamics, its inhibition had similar effects as the deletion of TmeA on invasion efficiency, consistent with the proposed model that TarP and TmeA act on different stages of the same invasion pathway.</p>
TARP 2019: SU 2044, SU 2046, SU 2047
Photogrammetric capture of stratigraphic units 2044, 2046, and 2047. Source: Objaverse 1.0 / Sketchfab
TARP 2021: SUs 3001-3016
SU 3001, SU 3002, SU 3003, SU 3004, SU 3005, SU 3006, SU 3007, SU 3008, SU 3009, SU 3010, SU 3011, SU 3012, SU 3013, SU 3014, SU 3015, SU 3016. Source: Objaverse 1.0 / Sketchfab
Dynamin-dependent entry of Chlamydia trachomatis is sequentially regulated by the effectors TarP and TmeA
<p><em>Chlamydia</em> invasion of epithelial cells is a pathogen-driven process involving two functionally distinct effectors – TarP and TmeA. They collaborate to promote robust actin dynamics at sites of entry. Here, we extend studies on the molecular mechanism of invasion by implicating the host GTPase dynamin 2 (Dyn2) in the completion of pathogen uptake. Importantly, Dyn2 function is modulated by TarP and TmeA at the levels of recruitment and activation through oligomerization, respectively. TarP-dependent recruitment requires phosphatidylinositol 3-kinase and the small GTPase Rac1, while TmeA has a post-recruitment role related to Dyn2 oligomerization. This is based on the rescue of invasion duration and efficiency in the absence of TmeA by the Dyn2 oligomer-stabilizing small molecule activator Ryngo 1-23. Notably, Dyn2 also regulated the turnover of TarP- and TmeA-associated actin networks, with disrupted Dyn2 function resulting in aberrant turnover dynamics, thus establishing the interdependent functional relationship between Dyn2 and the effectors TarP and TmeA.</p>
A Pilot Study of Vaccination With Epitope-Enhanced TARP Peptide and TARP Peptide-Pulsed Dendritic Cells in the Treatment of Stage D0 Prostate Cancer
ClinicalTrials.gov study NCT00972309. IPD Sharing: YES. Countries: 1. Publications: 4.
Distinct roles of the Chlamydia trachomatis effectors TarP and TmeA in the regulation of formin and Arp2/3 during entry
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Polyethylene tarping elevates temperature and reduces emergence of <em>Phloeosinus punctatus</em> LeConte (Coleoptera: Curculionidae) from giant sequoia debris piles
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Dynamin-dependent entry of Chlamydia trachomatis is sequentially regulated by the effectors TarP and TmeA
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TARP 2019: SU 2083
Photogrammetric capture of stratigraphic unit 2083 Source: Objaverse 1.0 / Sketchfab
TARP 2019: SU 2073-2076
Photogrammetric capture of stratigraphic units 2073-2076 Source: Objaverse 1.0 / Sketchfab
TARP 2019: SU 2063 - SU 2065
Photogrammetric capture of stratigraphic units 2063-2065 Source: Objaverse 1.0 / Sketchfab
TARP 2019: SU 2084
Photogrammetric capture of stratigraphic unit 2084. Source: Objaverse 1.0 / Sketchfab
TARP 2019: SU 1044, SU 1060
Photogrammetric capture of stratigraphic units 1044, 1060 Source: Objaverse 1.0 / Sketchfab
TARP 2019: SU 2028 - SU 2032
Photogrammetric capture of stratigraphic units 2028-2032. Source: Objaverse 1.0 / Sketchfab
TARP 2019: SU 2066 - SU 2068
Photogrammetric capture of stratigraphic units 2066-2068 Source: Objaverse 1.0 / Sketchfab
TARP 2019: SU 1113
Photogrammetric capture of stratigraphic unit 1113 Source: Objaverse 1.0 / Sketchfab
TARP 2019: SU 2079
Photogrammetric capture of stratigraphic unit 2079 Source: Objaverse 1.0 / Sketchfab
TARP 2019: SU 2017
Photogrammetric capture of stratigraphic unit 2017 Source: Objaverse 1.0 / Sketchfab
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