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119 results for “TCDD”
Data from: Single cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice
<p>2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently induces the development of hepatic fat accumulation and inflammation with fibrosis in mice initially in the portal region. Conversely, differential gene and protein expression is first detected in the central region. To further investigate cell-specific and spatially resolved dose-dependent changes in gene expression elicited by TCDD, single-nuclei RNA sequencing and spatial transcriptomics were used for livers of male mice gavaged with TCDD every 4 days for 28 days. The proportion of 11 cell (sub)types across 131,613 nuclei dose-dependently changed with 68% of all portal and central hepatocyte nuclei in control mice being overtaken by macrophages following TCDD treatment. We identified 368 (portal fibroblasts) to 1,339 (macrophages) differentially expressed genes. Spatial analyses revealed initial loss of portal identity that eventually spanned the entire liver lobule with increasing dose. Induction of R-spondin 3 (<em>Rspo3</em>) and pericentral <em>Apc</em>, suggested dysregulation of the Wnt/β-catenin signaling cascade in zonally resolved steatosis. Collectively, the integrated results suggest disruption of zonation contributes to the pattern of TCDD-elicited NAFLD pathologies.</p>
Data from: Single cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice
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Western blots of liver-expressed genes in C57BL/NCrl mice gavaged every 4 days for 28 days with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
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Hepatic pyruvate kinase muscle isoform 2 (Pkm2) induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-elicited oxidative stress is independent of NRF2 (RNA-Seq)
GEO Series GSE109863. Mus musculus. 42 samples. Type: Expression profiling by high throughput sequencing.
In utero and lactational exposure to TCDD induces disruption of prostate glands and fibrosis in rhesus monkeys
GEO Series GSE20043. Macaca mulatta. 9 samples. Type: Expression profiling by array.
RNA-Seq Analysis of Dose-Dependent TCDD-Elicited Duodenal Gene Expression in Male Mice
GEO Series GSE87542. Mus musculus. 27 samples. Type: Expression profiling by high throughput sequencing.
Global gene expression profiling in A549 cells exposed to TCDD, CH223191 or TCDD+CH223191 for 6 h
GEO Series GSE109576. Homo sapiens. 12 samples. Type: Expression profiling by array.
Global transcriptional response in Japanese medaka larvae following embryonic exposure to TCDD
GEO Series GSE87168. Oryzias latipes. 6 samples. Type: Expression profiling by high throughput sequencing.
Dose-response hepatic single nuclei RNA sequencing of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated mice
GEO Series GSE184506. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional Profiling of rat hypothalamic response to TCDD
GEO Series GSE61039. Rattus norvegicus. 16 samples. Type: Expression profiling by array.
TCDD-mediated multigenerational effects in mice
GEO Series GSE220204. synthetic construct; Mus. 6 samples. Type: Non-coding RNA profiling by array.
Transcriptomic analyses of TCDD treated zebrafish liver
GEO Series GSE49915. Danio rerio. 2 samples. Type: Expression profiling by high throughput sequencing.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters Hepatic Polyunsaturated Fatty Acid Metabolism and Eicosanoid Biosynthesis in Female Sprague-Dawley Rats
GEO Series GSE110294. Rattus norvegicus. 34 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Conserved Transcriptional Response of Rodent Liver to TCDD: Mouse
GEO Series GSE10769. Mus musculus. 11 samples. Type: Expression profiling by array.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters Hepatic Polyunsaturated Fatty Acid Metabolism and Eicosanoid Biosynthesis in Female Sprague-Dawley Rats [RNA-Seq]
GEO Series GSE110293. Rattus norvegicus. 24 samples. Type: Expression profiling by high throughput sequencing.
RNA-Seq Versus Oligonucleotide Array Assessment of Dose-Dependent TCDD-elicited Hepatic Gene Expression in Mice
GEO Series GSE62903. Mus musculus. 93 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing.
Whole Genome Bisulfite Sequencing of CD4+ T cells from mice developmentally exposed to vehicle or TCDD prior to and during influenza infection
GEO Series GSE143893. Mus musculus. 12 samples. Type: Methylation profiling by high throughput sequencing.
MicroRNA expression profiling after short-term exposure to TCDD in zebrafish embryos
GEO Series GSE39809. Danio rerio; Homo sapiens; Rattus norvegicus; JC polyomavirus; Betapolyomavirus hominis; Mus musculus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Betapolyomavirus macacae. 36 samples. Type: Non-coding RNA profiling by array; Non-coding RNA profiling by high throughput sequencing.
TCDD exposure in control and slincR zebrafish morphants at 48 hpf
GEO Series GSE106131. Danio rerio. 16 samples. Type: Expression profiling by high throughput sequencing.
Global gene expression profiling in HepaRG cells exposed to TCDD for 24 h
GEO Series GSE122518. Homo sapiens. 8 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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