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29 results for “TDT”
Expression of terminal deoxynucleotidyl transferase (TdT) identifies lymphoid-primed progenitors in human bone marrow
<p><span>With emerging single-cell techniques in the human hematopoiesis, discrepancies between the traditional cell-surface-marker-based cell-type identification and their single-cell level molecular phenotype are observed. To better associate lymphoid identity with protein-level cell features, we examined the protein expression of terminal deoxynucleotidyl transferase (TdT), a specialized DNA polymerase intrinsic to VDJ recombination, and detected TdT expression within CD34+ progenitors prior to B/T cell emergence. While these TdT+ cells coincided with granulocyte-monocyte progenitor (GMP) immunophenotype, their accessible chromatin regions showed enrichment for lymphoid-associated transcription factor (TF) motifs. TdT expression on GMPs was inversely related to the SLAM family member CD84. Prospective isolation of CD84lo GMPs demonstrated robust lymphoid potential ex vivo, while still retaining significant myeloid differentiation capacity, akin to LMPPs. This multi-omic study identifies previously unappreciated lymphoid-primed progenitors, redefining the lympho-myeloid axis in human hematopoiesis.</span></p>
Expression of terminal deoxynucleotidyl transferase (TdT) identifies lymphoid-primed progenitors in human bone marrow
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Long-term Follow-up of Subjects With Transfusion-Dependent β-Thalassemia (TDT) Treated With Ex Vivo Gene Therapy
ClinicalTrials.gov study NCT02633943. IPD Sharing: YES. Countries: 8. Publications: 3.
A Study Evaluating the Safety and Efficacy of LentiGlobin BB305 Drug Product in β-Thalassemia Major (Also Referred to as Transfusion-dependent β-Thalassemia [TDT]) and Sickle Cell Disease
ClinicalTrials.gov study NCT02151526. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Study to Assess the Safety, Tolerability, and Efficacy of ST-400 for Treatment of Transfusion-Dependent Beta-thalassemia (TDT)
ClinicalTrials.gov study NCT03432364. IPD Sharing: NO. Countries: 1. Publications: 1.
EDIT-301 for Autologous Hematopoietic Stem Cell Transplant (HSCT) in Participants With Transfusion-Dependent Beta Thalassemia (TDT)
ClinicalTrials.gov study NCT05444894. IPD Sharing: NO. Countries: 2. Publications: 0.
Study of Cordycepin Plus Pentostatin in Patients With Refractory TdT-Positive Leukemia
ClinicalTrials.gov study NCT00709215. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Use of the TDT for Prevention of Anastomotic Leakage After Laparoscopic Anterior Resection for Rectal Cancer
ClinicalTrials.gov study NCT02686567. IPD Sharing: YES. Countries: 1. Publications: 7.
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Transfusion-Dependent β-Thalassemia (TDT)
ClinicalTrials.gov study NCT05356195. IPD Sharing: NO. Countries: 5. Publications: 0.
A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)
ClinicalTrials.gov study NCT04770779. IPD Sharing: NO. Countries: 19. Publications: 0.
MERRA-2 tavgU_3d_tdt_Np: 3d,diurnal,Time-Averaged,Pressure-Level,Assimilation,Temperature Tendencies 0.625 x 0.5 degree V5.12.4 (M2TUNPTDT) at GES DISC
M2TUNPTDT (or tavgU_3d_tdt_Np) is a 3-dimensional monthly diurnal means data collection in Modern-Era Retrospective analysis for Research and Applications version 2 (MERRA-2). This collection consists of assimilations of air temperature tendencies on 42 pressure levels, such as total temperature analysis tendency, and tendency of air temperature due to dynamics (or friction, moisture, radiation, and physics). The information on the pressure levels can be found in the section 4.2 of the MERRA-2 File Specification document. This data collection is the monthly mean of data fields for each 3-hour and time-stamped at the central time starting from 01:30 UTC, e.g.: 01:30, 04:30, … , 22:30 UTC.MERRA-2 is the latest version of global atmospheric reanalysis for the satellite era produced by NASA Global Modeling and Assimilation Office (GMAO) using the Goddard Earth Observing System Model (GEOS) version 5.12.4. The dataset covers the period of 1980-present with the latency of ~3 weeks after the end of a month. Data Reprocessing: Please check “Records of MERRA-2 Data Reprocessing and Service Changes” linked from the “Documentation” tab on this page. Note that a reprocessed data filename is different from the original file.MERRA-2 Mailing List: Sign up to receive information on reprocessing of data, changing of tools and services, as well as data announcements from GMAO. Contact the GES DISC Help Desk (gsfc-dl-help-disc@mail.nasa.gov) to be added to the list.Questions: If you have a question, please read "MERRA-2 File Specification Document", “MERRA-2 Data Access – Quick Start Guide”, and FAQs linked from the ”Documentation” tab on this page. If that does not answer your question, you may post your question to the NASA Earthdata Forum (forum.earthdata.nasa.gov) or email the GES DISC Help Desk (gsfc-dl-help-disc@mail.nasa.gov).
MERRA-2 tavg3_3d_tdt_Np: 3d,3-Hourly,Time-Averaged,Pressure-Level,Assimilation,Temperature Tendencies 0.625 x 0.5 degree V5.12.4 (M2T3NPTDT) at GES DISC
M2T3NPTDT (or tavg3_3d_tdt_Np) is a 3-dimensional 3-hourly time averaged data collection in Modern-Era Retrospective analysis for Research and Applications version 2 (MERRA-2). This collection consists of assimilations of air temperature tendencies on 42 pressure levels, such as total temperature analysis tendency, and tendency of air temperature due to dynamics (or friction, moisture, radiation, and physics). The data field is available every three hour starting from 01:30 UTC, e.g.: 01:30, 04:30, … , 22:30 UTC. The information on the pressure levels can be found in the section 4.2 of the MERRA-2 File Specification document. MERRA-2 is the latest version of global atmospheric reanalysis for the satellite era produced by NASA Global Modeling and Assimilation Office (GMAO) using the Goddard Earth Observing System Model (GEOS) version 5.12.4. The dataset covers the period of 1980-present with the latency of ~3 weeks after the end of a month. Data Reprocessing: Please check “Records of MERRA-2 Data Reprocessing and Service Changes” linked from the “Documentation” tab on this page. Note that a reprocessed data filename is different from the original file.MERRA-2 Mailing List: Sign up to receive information on reprocessing of data, changing of tools and services, as well as data announcements from GMAO. Contact the GES DISC Help Desk (gsfc-dl-help-disc@mail.nasa.gov) to be added to the list.Questions: If you have a question, please read "MERRA-2 File Specification Document", “MERRA-2 Data Access – Quick Start Guide”, and FAQs linked from the ”Documentation” tab on this page. If that does not answer your question, you may post your question to the NASA Earthdata Forum (forum.earthdata.nasa.gov) or email the GES DISC Help Desk (gsfc-dl-help-disc@mail.nasa.gov).
MERRA-2 tavgM_3d_tdt_Np: 3d,Monthly mean,Time-Averaged,Pressure-Level,Assimilation,Temperature Tendencies 0.625 x 0.5 degree V5.12.4 (M2TMNPTDT) at GES DISC
M2TMNPTDT (or tavgM_3d_tdt_Np) is a 3-dimensional monthly mean data collection in Modern-Era Retrospective analysis for Research and Applications version 2 (MERRA-2). This collection consists of assimilations of air temperature tendencies on 42 pressure levels, such as total temperature analysis tendency, and tendency of air temperature due to dynamics (or friction, moisture, radiation, and physics). The information on the pressure levels can be found in the section 4.2 of the MERRA-2 File Specification document. The collection also includes variance of certain parameters.MERRA-2 is the latest version of global atmospheric reanalysis for the satellite era produced by NASA Global Modeling and Assimilation Office (GMAO) using the Goddard Earth Observing System Model (GEOS) version 5.12.4. The dataset covers the period of 1980-present with the latency of ~3 weeks after the end of a month. Data Reprocessing: Please check “Records of MERRA-2 Data Reprocessing and Service Changes” linked from the “Documentation” tab on this page. Note that a reprocessed data filename is different from the original file.MERRA-2 Mailing List: Sign up to receive information on reprocessing of data, changing of tools and services, as well as data announcements from GMAO. Contact the GES DISC Help Desk (gsfc-dl-help-disc@mail.nasa.gov) to be added to the list.Questions: If you have a question, please read "MERRA-2 File Specification Document", “MERRA-2 Data Access – Quick Start Guide”, and FAQs linked from the ”Documentation” tab on this page. If that does not answer your question, you may post your question to the NASA Earthdata Forum (forum.earthdata.nasa.gov) or email the GES DISC Help Desk (gsfc-dl-help-disc@mail.nasa.gov).
Next Generation Sequencing of T regulatory cells (GFP+, dTomato+) and ex-T regulatory cells (GFP-, dTomato+) harvested from lymph nodes of bone marrow chimeras (50% Foxp3GFP-tdT or Foxp3GFP-Fth/-tdT
GEO Series GSE226032. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Comparison of expression in Arabidopsis mutant tdt-1 and wild type
GEO Series GSE7359. Arabidopsis thaliana. 3 samples. Type: Expression profiling by array.
Humanized V(D)J-rearranging and TdT-expressing Mouse Vaccine Models with Physiological HIV-1 Broadly Neutralizing Antibody Precursors
GEO Series GSE214884. Homo sapiens; Mus musculus. 54 samples. Type: Other.
Comparing the transcriptome expression differences between breast cancer cells EO771-tdT-Parental and EO771-tdT-LM2 using high-throughput sequencing.
GEO Series GSE263184. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile at single cell level of two TDT patients' PBMCs after gene editing treatment.
GEO Series GSE204688. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
TDT 067 Onychomycosis Study
ClinicalTrials.gov study NCT01145807. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study Evaluating the Safety and Efficacy of LentiRed Drug Product in Transfusion-dependent β-Thalassemia [TDT]
ClinicalTrials.gov study NCT05762510. IPD Sharing: NO. Countries: 1. Publications: 0.
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