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109 results for “TERT”
S67 | TBUTYLPHENOLS | List of tert-butyl phenols from KEMI
<p>This is the collection associated with list S67 TBUTYLPHENOLS List of tert-butyl phenols from KEMI on the NORMAN Suspect List Exchange.</p> <p><a href="https://www.norman-network.com/nds/SLE/">https://www.norman-network.com/nds/SLE/</a></p> <p>A list of tert-butyl phenols from KEMI (Swedish Chemicals Agency), partner list to BISPHENOLS. Includes exposure score. Dataset DOI: 10.5281/zenodo.3779849.</p>
Data for "Synthesis of zirconium(IV) and hafnium(IV) isopropoxide, sec-butoxide and tert-butoxide"
<p>Data of the figures in the publication "<strong>Synthesis of zirconium(IV) and hafnium(IV) isopropoxide, sec-butoxide and tert-butoxide</strong>".</p> <p>The <em>.pxp</em> documents contain the experimental data of the figures in the manuscript and they can be opened/edited with the software IGOR Pro 8.0 or higher.</p> <p>Table of contents:</p> <p><strong>Figure 1.</strong> The synthesis of zirconium(<span>iv</span>) and hafnium(<span>iv</span>) isopropoxide isopropanol complex. (A) General reaction scheme of both the method making use of ammonia stock solution in isopropanol, and gaseous ammonia, (B) <sup>1</sup>H NMR, and (C) <sup>13</sup>C NMR of zirconium(<span>iv</span>) and hafnium(<span>iv</span>) isopropoxide isopropanol complex in C<sub>6</sub>D<sub>6</sub>.</p> <p><strong>Figure 2.</strong> Exchange reaction of zirconium isopropoxide isopropanol complex with the more Lewis base TOPO. (A) General reaction scheme, (B) <sup>1</sup>H NMR of the as-synthesized zirconium(<span>iv</span>) isopropoxide isopropanol complex where the ratio between the three resonances (6.5, 4.5 and 1.5 ppm) equals to 1 : 5 : 30 (= 4 isopropoxides and 1 isopropanol), (C) to which an excess of TOPO is added where the ratio between the three resonances (4.5, 4.0 and 3.0 ppm) equals to 4 : 1 : 1 (confirms the correct stoichiometry of 4 isopropoxides and 1 isopropanol), and (D) <sup>31</sup>P NMR of the mixture in C<sub>6</sub>D<sub>6</sub>.</p> <p><strong>Figure 3.</strong> The synthesis of zirconium(<span>iv</span>) and hafnium(<span>iv</span>) diethylamido complex. (A) General reaction scheme, (B) <sup>1</sup>H NMR, and (C) <sup>13</sup>C NMR of zirconium(<span>iv</span>) and hafnium(<span>iv</span>) diethylamido complex in C<sub>6</sub>D<sub>6</sub>.</p> <p><strong>Figure 4.</strong> The synthesis of zirconium(<span>iv</span>) and hafnium(<span>iv</span>) <em>tert</em>-butoxide complex. (A) General reaction scheme, (B) <sup>1</sup>H NMR, and (C) <sup>13</sup>C NMR of zirconium(<span>iv</span>) and hafnium(<span>iv</span>) <em>tert</em>-butoxide complex in C<sub>6</sub>D<sub>6</sub>.</p> <p><strong>Figure 5.</strong> The synthesis of zirconium(<span>iv</span>) <em>sec</em>-butoxide. (A) General reaction scheme, (B) <sup>1</sup>H NMR, and (C) <sup>13</sup>C NMR of zirconium(<span>iv</span>) <em>sec</em>-butoxide in C<sub>6</sub>D<sub>6</sub>.</p> <p><strong>Figure 6.</strong> Interaction of zirconium <em>sec</em>-butoxide with TOPO. (A) <sup>1</sup>H NMR of the as-synthesized zirconium(<span>iv</span>) <em>sec</em>-butoxide to which TOPO is added, and (B) <sup>31</sup>P NMR of the mixture in C<sub>6</sub>D<sub>6</sub>.</p> <p><strong>Figure S1.</strong> Schematic diagram of the reversible glass frit and pictures of the air- and moisture-free Schlenk filtration.</p> <p><strong>Figure S2.</strong> Powder XRD of (left) the synthesized Zr(OiPr)4.iPrOH and the calculated powder diffraction pattern from the CSD reference JETWOU, and (right) the synthesized Hf(OiPr)4.iPrOH and the calculated powder diffraction pattern from the CSD reference NAYDAS.</p>
Data sets for Shiburah et al., "The absence of the Leishmania major telomerase TERT component links telomeres and cell homeostasis with infectivity"
<p>These files correspond to the figures and information contained in Shiburah et al., "The absence of the <em>Leishmania major</em> telomerase TERT component links telomeres and cell homeostasis with infectivity"</p>
Summary statistics for "Variants in the TERT gene increase the occurrence of solar lentigines by modifying telomerase expression exclusively in the skin"
<p>Publication: Deecke et al., Variants in the TERT gene increase the occurrence of solar lentigines by modifying telomerase expression exclusively in the skin, manuscript under revision<br> <br> Brief summary:<br> Solar lentigines (SL) are a characteristic of the aging skin. Their occurrence is likely determined by a combination of genetic variants and environmental factors such as chronic sun exposure. However, the genetic factors underlying SL formation remain largely unknown. A recently performed genome-wide association study (GWAS) of SL in two Chinese cohorts reported <em>TERT</em> and <em>OCA2</em> as novel genome-wide significant genetic loci for SL, while only the <em>TERT</em> locus could be validated in a cohort of European descent (Peng et al, 2023). The telomerase reverse transcriptase TERT is known to be involved in the process of maintenance of telomere lengths, but interestingly no causal relationship between telomere length and the SL GWAS results was observed by the investigators.</p> <p>In this study, we quantified the heritability of SL located on the back of the hands and performed a de novo GWAS in 1,137 elderly participants (aged 60 and more) of European descent from the Berlin Aging Study II. We confirmed <em>TERT</em> as the only genome-wide significant locus for SL (top SNP: rs2735940, p= 1.35E-16). In line with the previous Mendelian Randomization (MR) results by Peng et al., our updated MR using substantially larger datasets did not show a causal relationship between the occurrence of SL and telomere lengths measured in blood leukocytes. Importantly, rs2735940 modifies <em>TERT</em> expression in skin tissue (based on GTEx data), but not in any of the other GTEx tissues including blood. Furthermore, colocalization analyses suggested a shared causal effect of rs2735940 on SL occurrence and on <em>TERT</em> expression in skin but not in blood.</p> <p>Thus, we could show that variants in the <em>TERT</em> gene increase the occurrence of SL by modifying <em>TERT</em> expression exclusively in the skin, based on currently available GTEx data. This skin-specific effect was not reported previously and may provide the hitherto missing functional link for the occurrence of SLs via <em>TERT</em> expression and telomere length alterations.</p>
Supplementary materials for [BRAF-induced EHF expression affects TERT in aggressive papillary thyroid cancer]
<p>Supplementary figures and tables for [BRAF-induced EHF expression affects TERT in aggressive papillary thyroid cancer].</p>
Influence of Alkali Metal Cations in the Formation of the Heterobimetallic Actinide tert-Butoxides [AnM3(OtBu)7] and [AnM2(OtBu)6] (AnIV = Th, U; MI = Li, Na, K, Rb, Cs)
<p>These are the raw data for the modulated structure pertaining to compound <strong>URb</strong>. The following is the abstract of the corresponding paper.</p> <p>Heterobimetallic <em>tert</em>-butoxides of alkali metal cations and tetravalent actinide centers exhibit two distinctive structural motifs, [AnM<sub>2</sub>(O<em><sup>t</sup></em>Bu)<sub>6</sub>] and [AnM<sub>3</sub>(O<em><sup>t</sup></em>Bu)<sub>7</sub>] (An<sup>IV</sup> = Th, U and M<sup>I</sup> = Li, Na, K, Rb, Cs), evidently govern by the size of the alkali metal ions. Both [AnM<sub>3</sub>(O<em><sup>t</sup></em>Bu)<sub>7</sub>] <strong>AnM3 </strong>(An<sup>IV</sup> = U, M<sup>I</sup> = Li; An<sup>IV</sup> = Th, M<sup>I</sup> = Li, Na) and<strong> </strong>[AnM<sub>2</sub>(O<em><sup>t</sup></em>Bu)<sub>6</sub>] <strong>AnM2</strong> (An<sup>IV</sup> = U, M<sup>I</sup> = Na – Cs; An<sup>IV</sup> = Th, M<sup>I</sup> = K - Cs) compounds are obtained in nearly quantitative yields by reacting the actinide and alkali metal silyl amides with excess of <em>tert</em>-butyl alcohol. The <strong>AnM3</strong> complexes form a cubane-type coordination motif, whereas the <strong>AnM2</strong> complexes display a geometry resembling two face-shared bipyramids. The sodium derivatives of thorium and uranium (<strong>ThNa3</strong> and <strong>UNa2</strong>) allow to determine the structural transition threshold as function of the ratio of the ionic radii, r<sub>i</sub>(An<sup>IV</sup>)/r<sub>i</sub>(M<sup>I</sup>). The <strong>AnM3</strong> complexes are formed for ratios above 0.92 and the <strong>AnM2</strong> type is formed for ratios below 0.87. All compounds are unambiguously characterized in both solution and the solid-state via NMR and IR spectroscopic studies and single crystal X-ray diffraction analyses, respectively.</p>
Influence of Alkali Metal Cations in the Formation of the Heterobimetallic Actinide tert-Butoxides [AnM3(OtBu)7] and [AnM2(OtBu)6] (AnIV = Th, U; MI = Li, Na, K, Rb, Cs)
<p>These are the raw data the compound <strong>ThCs2</strong>, refined as a merohedral twin. The following is the abstract of the corresponding paper.</p> <p>Heterobimetallic <em>tert</em>-butoxides of alkali metal cations and tetravalent actinide centers exhibit two distinctive structural motifs, [AnM<sub>2</sub>(O<em><sup>t</sup></em>Bu)<sub>6</sub>] and [AnM<sub>3</sub>(O<em><sup>t</sup></em>Bu)<sub>7</sub>] (An<sup>IV</sup> = Th, U and M<sup>I</sup> = Li, Na, K, Rb, Cs), evidently govern by the size of the alkali metal ions. Both [AnM<sub>3</sub>(O<em><sup>t</sup></em>Bu)<sub>7</sub>] <strong>AnM3 </strong>(An<sup>IV</sup> = U, M<sup>I</sup> = Li; An<sup>IV</sup> = Th, M<sup>I</sup> = Li, Na) and<strong> </strong>[AnM<sub>2</sub>(O<em><sup>t</sup></em>Bu)<sub>6</sub>] <strong>AnM2</strong> (An<sup>IV</sup> = U, M<sup>I</sup> = Na – Cs; An<sup>IV</sup> = Th, M<sup>I</sup> = K - Cs) compounds are obtained in nearly quantitative yields by reacting the actinide and alkali metal silyl amides with excess of <em>tert</em>-butyl alcohol. The <strong>AnM3</strong> complexes form a cubane-type coordination motif, whereas the <strong>AnM2</strong> complexes display a geometry resembling two face-shared bipyramids. The sodium derivatives of thorium and uranium (<strong>ThNa3</strong> and <strong>UNa2</strong>) allow to determine the structural transition threshold as function of the ratio of the ionic radii, r<sub>i</sub>(An<sup>IV</sup>)/r<sub>i</sub>(M<sup>I</sup>). The <strong>AnM3</strong> complexes are formed for ratios above 0.92 and the <strong>AnM2</strong> type is formed for ratios below 0.87. All compounds are unambiguously characterized in both solution and the solid-state via NMR and IR spectroscopic studies and single crystal X-ray diffraction analyses, respectively.</p>
Oxidative Stress and Mitochondrial TERT in Papillary Thyroid Cancer.
ClinicalTrials.gov study NCT05752669. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Sub-lobectomy for IDH Wild-type and TERT Promoter Mutant Glioblastoma
ClinicalTrials.gov study NCT06368934. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Chronic dietary exposure to the food preservative tert-Butylhydroquinone (tBHQ) impairs zebrafish (Danio rerio) survival, growth, organ development, and gene expression in Nrf2a-dependent and independ
GEO Series GSE220834. Danio rerio. 12 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in human bone marrow Mesenchymal Stem cell line (hMSC-TERTs) during proliferation, quiescence (G0-arrest) and re-activation.
GEO Series GSE60608. Homo sapiens. 15 samples. Type: Expression profiling by array.
Roles of mammalian Rap1 in TERT recruitment to chromatin, subtelomeric gene silencing and transcriptional regulation
GEO Series GSE19011. Mus musculus. 6 samples. Type: Expression profiling by array.
TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment
GEO Series GSE169715. Homo sapiens; Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
Altered gene expression in zebrafish embryos exposed to tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin
GEO Series GSE10157. Danio rerio. 12 samples. Type: Expression profiling by array.
Genomic analysis of mice with endothelium-specific TERT knockout (scRNA-Seq)
GEO Series GSE239687. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
GABP determines the epigenetic status of mutant TERT promoter
GEO Series GSE77265. Homo sapiens. 8 samples. Type: Other.
Genome-wide analysis of iPSC-derived neurons with EGFP or TERT transduction
GEO Series GSE163525. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Analysis of HPV16 E2 host gene expression using TERT immortalized keratinocytes (NOKs) cell lines and RNA-sequencing
GEO Series GSE121627. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
The effect of tert-butyl hydroperoxide on hepatic multi-transcript patterns of the sentinel fish Lithognathus mormyrus
GEO Series GSE19216. Lithognathus mormyrus. 5 samples. Type: Expression profiling by array.
Genomic and Epigenomic EBF1 Alterations Modulate TERT Expression in Gastric Cancer
GEO Series GSE121140. Homo sapiens. 75 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.