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ShareScore release 0.9.0
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9 results for “TRPV2”
Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel
<p><span>Transient receptor potential vanilloid 2 (TRPV2) is a multimodal ion channel implicated in diverse physiopathological processes.</span><span> Its important involvement in immune responses has been suggested such as in the macrophages' phagocytosis process. However, the endogenous signaling cascades controlling the gating of TRPV2 remain to be understood. Here, we report that enhancing tyrosine phosphorylation remarkably alters the chemical and thermal sensitivities of TRPV2 endogenously expressed in</span><span> rat bone marrow-derived macrophages. We identify that the </span><span>protein tyrosine kinase </span><span>JAK1 mediates TRPV2 phosphorylation at the molecular sites Tyr(335), Tyr(471), and Tyr(525). JAK1 phosphorylation is required for maintaining TRPV2 activity and the phagocytic ability of macrophages. We further show that TRPV2 phosphorylation is dynamically balanced by protein tyrosine phosphatase</span><span> non-receptor type 1 (</span><span>PTPN1). PTPN1 inhibition increases TRPV2 phosphorylation, further reducing the activation temperature threshold. Our data thus unveil an intrinsic mechanism where the phosphorylation/dephosphorylation dynamic balance sets the basal chemical and thermal sensitivity of TRPV2. Targeting this pathway will aid therapeutic interventions in physiopathological contexts.</span></p>
Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel
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Functional and structural insights into activation of TRPV2 by weak acids
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TRPV2 Agonists in the Fontan Circulation
ClinicalTrials.gov study NCT03965351. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Exploring the Vestibulocerebellum- Vestibular Nuclei - Spinal Trigeminal Nucleus Causals communication and TRPV2 ion channel in vestibular migraine pathogenesis
GEO Series GSE290448. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
TCAF1 Promotes TRPV2-mediated Ca2+ Release in Response to Cytosolic DNA to Protect Stressed Replication Forks
GEO Series GSE244205. Homo sapiens. 8 samples. Type: Other.
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
GEO Series GSE131660. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Molecular dynamics simulation of rat EDAA TRPV2 with drugs
<p>Molecular dynamics simulation trajectory, parameter files for the systems of rat EDAA TRPV2 with drugs.</p>
RNA-seq HepG2 cell line treated with TRPV2 inhinitor or agonist
GEO Series GSE221726. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.