Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
25
datasets available to search
ShareScore release 0.9.0
Dataset results
25 results for “Target of Rapamycin”
The social network of target of rapamycin complex 1 in plants
<p>The target of rapamycin complex 1 (TORC1) is a highly conserved serine–threonine protein kinase crucial for coordinating growth according to nutrient availability in eukaryotes. It works as a central integrator of multiple nutrient inputs such as sugar, nitrogen, and phosphate and promotes growth and biomass accumulation in response to nutrient sufficiency. Studies, especially in the past decade, have identified the central role of TORC1 in regulating growth through interaction with hormones, photoreceptors, and stress-signaling machinery in plants. In this review, we comprehensively analyse the interactome and phosphoproteome of the Arabidopsis TORC1 signaling network. Our analysis highlights the role of TORC1 as a central hub kinase communicating with the transcriptional and translational apparatus, ribosomes, chaperones, protein kinases, metabolic enzymes, and autophagy and stress response machinery to orchestrate growth in response to nutrient signals. This analysis also suggests that along with the conserved downstream components shared with other eukaryotic lineages, plant TORC1 signaling underwent several evolutionary innovations and co-opted many lineage-specific components. Based on the protein–protein interaction and phosphoproteome data, we also discuss several uncharacterized and unexplored components of the TORC1 signaling network, highlighting potential links for future studies.</p>
The social network of target of rapamycin complex 1 in plants
Open the record for dataset details and reuse information.
Data for: Mouse sperm DNA-methylation changes induced by age and mechanistic target of rapamycin (mTOR) manipulation in Sertoli cells
Open the record for dataset details and reuse information.
Firehawk Rapamycin Target Eluting Coronary Stent North American Trial
ClinicalTrials.gov study NCT04562532. IPD Sharing: UNDECIDED. Countries: 5. Publications: 1.
Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune)
ClinicalTrials.gov study NCT05414292. IPD Sharing: YES. Countries: 1. Publications: 0.
Study of AP23573/MK-8669 (Ridaforolimus), A Mammalian Target of Rapamycin (mTOR) Inhibitor, in Participants With Advanced Sarcoma (MK-8669-018 AM1)(COMPLETED)
ClinicalTrials.gov study NCT00093080. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Phosphatidylinositol 3 Kinase and Mammalian Target of Rapamycin (PI3K-mTOR) in Advanced Cancer Patients
ClinicalTrials.gov study NCT00877773. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing
GEO Series GSE255002. Homo sapiens. 70 samples. Type: Expression profiling by high throughput sequencing.
Mechanistic target of rapamycin complex 1 orchestrates the interplay between hepatocytes and Kupffer cells to determine the outcome of immune-mediated hepatitis
GEO Series GSE218700. Mus musculus. 6 samples. Type: Expression profiling by array.
Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila
GEO Series GSE65691. Drosophila melanogaster. 5 samples. Type: Expression profiling by high throughput sequencing.
Dual inhibition of histone deacetylases and the mechanistic target of rapamycin promotes apoptosis in cell line models of uveal melanoma
GEO Series GSE155452. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Dietary Protein and Monocyte/Macrophage Mammalian Target of Rapamycin (mTOR) Signaling
ClinicalTrials.gov study NCT03946774. IPD Sharing: NO. Countries: 1. Publications: 0.
Phase 1 Trial of the Mammalian Target of Rapamycin (mTOR) Inhibitor Everolimus Plus Radiation Therapy (RT) for Salvage Treatment of Biochemical Recurrence in Prostate Cancer Patients Following Prostat
ClinicalTrials.gov study NCT01548807. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Randomized Trial of the Rapamycin Target Eluting Stent for the Treatment of Symptomatic Cerebral Artery Atherosclerotic Disease（TARGET-DREAM）
ClinicalTrials.gov study NCT06925971. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of the Inhibition of the Mammalian Target of Rapamycin on Metabolism and Exercise
ClinicalTrials.gov study NCT01561404. IPD Sharing: Not stated. Countries: 1. Publications: 0.
TARGET-PREMIER Trail in Evaluating the Safety and Efficacy of the Rapamycin Target Eluting Stent in CAS Treatment
ClinicalTrials.gov study NCT04951050. IPD Sharing: NO. Countries: 1. Publications: 0.
Autophagy Inhibition to Augment Mammilian Target of Rapamycin (mTOR) Inhibition: A Phase I/II Trial of RAD001 and Hydroxychloroquine (HCQ) in Patients With Previously Treated Renal Cell Carcinoma
ClinicalTrials.gov study NCT01510119. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of the Mammalian Target of Rapamycin (mTor Rapamycin) Inhibitor in Vascular Malformations
ClinicalTrials.gov study NCT01811667. IPD Sharing: Not stated. Countries: 1. Publications: 0.
CAR gene delivery by T-cell targeted lentiviral vectors is enhanced by rapamycin induced reduction of antiviral mechanisms
GEO Series GSE228824. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing.
Insulin-Like Growth Factor Receptor 1 and Mammalian Target Of Rapamycin Blockade: Novel Mechanisms of Resistance and Synergistic Drug Combinations for Ewing Sarcoma
GEO Series GSE78124. Homo sapiens. 54 samples. Type: Protein profiling by protein array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.