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38 results for “Testicular germ cell tumors”
FMPP and Testicular Germ Cell Tumors - Supplementary Data
<p>Objective: The purpose of this study is to report development of a malignant testicular<br> germ cell tumor (GCT) in two young adult males with Familial Male-limited Precocious<br> Puberty (FMPP) due to (LHCGR) pathogenic variants in two families. Secondary, to<br> study the possible relation between FMPP and testicular tumors and to investigate<br> whether FMPP might predispose to development of malignant testicular tumors in<br> adulthood a literature review is conducted. Methods: Data on six cases in two families<br> are obtained from the available medical records. In addition, a database search is<br> performed in Cochrane, Pubmed and Embase for studies that report on a possible link<br> between FMPP and testicular tumors. Results: The characteristics of six males with<br> FMPP based on activating luteinizing hormone receptor (LHCGR) germline pathogenic<br> variants are described, as well as details of the testicular GCTs. Furthermore, literature<br> review identified four more patients with signs of FMPP and a (precursor of a) testicular<br> GCT in adolescence or adulthood (age 15 to 35 years). Additionally, twelve patients<br> with signs of precocious puberty and, simultaneously, occurrence of a Leydig cell<br> adenoma or Leydig cell hyperplasia are reported. Conclusion: There is a strong<br> suggestion that FMPP might increase the risk of development of testicular GCTs in<br> early adulthood compared to the risk in the general population. Therefore, prolonged<br> patient monitoring from mid-pubertal age onwards including instruction for selfexamination<br> and periodic testicular ultrasound investigation in patients with a<br> germline LHCGRpathogenic variants might contribute to early detection and thus early<br> treatment of testicular GCT.</p> <p>This files contains the supplementary data. </p>
Impact of a Physical Activity Program to Reduce Long-term Cancer-related Fatigue in Metastatic Testicular Germ Cell Tumor Patients
ClinicalTrials.gov study NCT05588700. IPD Sharing: NO. Countries: 1. Publications: 1.
A Case-control Study to Assess the Association Between Environmental, Domestic and Occupational Exposures and the Risk of Testicular Germ Cell Tumor
ClinicalTrials.gov study NCT02109926. IPD Sharing: Not stated. Countries: 1. Publications: 44.
Comprehensive analysis of microRNA expression provides mechanistic insights into transcriptomic alteration in primary and metastatic testicular germ cell tumors
GEO Series GSE301954. Homo sapiens. 45 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Gene Expression Signatures Prognostic for Relapse in Stage I Testicular Germ Cell Tumors (TGCT)
GEO Series GSE99420. Homo sapiens. 60 samples. Type: Expression profiling by array.
Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumors
GEO Series GSE216043. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Hypermethylation and global remodeling of DNA methylation associated with acquired cisplatin resistance in testicular germ cell tumors
GEO Series GSE156512. Homo sapiens. 21 samples. Type: Methylation profiling by array.
Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methlation inhibitor guadecitabine
GEO Series GSE90681. Homo sapiens. 6 samples. Type: Expression profiling by array.
microRNA profiling of normal testes and testicular germ cell tumors using deep sequencing approach
GEO Series GSE59267. Homo sapiens. 11 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors
GEO Series GSE74104. Homo sapiens. 267 samples. Type: Methylation profiling by genome tiling array.
Testicular germ cell tumors and their histological subgroups
GEO Series GSE1818. Homo sapiens. 30 samples. Type: Expression profiling by array.
Downregulation of polycomb repressive complex 2 mediates cisplatin acquired resistant in testicular germ cell tumors
GEO Series GSE129696. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
microRNA expression of cancer and matched adjacent tissues from 7 testicular germ cell tumors and 10 transitional cell carcinomas of bladder
GEO Series GSE31616. Homo sapiens. 34 samples. Type: Non-coding RNA profiling by high throughput sequencing.
mRNA expression of cancer and matched adjacent tissues of 7 testicular germ cell tumors and 10 transitional cell carcinomas of bladder
GEO Series GSE31614. Homo sapiens. 34 samples. Type: Expression profiling by high throughput sequencing.
Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B
GEO Series GSE278498. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Targeting cancer stem cells with differentiation agents as an alternative to genotoxic chemotherapy for the treatment of malignant testicular germ cell tumors
GEO Series GSE168261. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors
ClinicalTrials.gov study NCT07218913. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors
ClinicalTrials.gov study NCT00002489. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Germ Cell Tumor and Testicular Tumor DNA Registry
ClinicalTrials.gov study NCT02099734. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Toxicity Attributed to Genetic Polymorphisms in Testicular Germ Cell Tumor Survivors
ClinicalTrials.gov study NCT02303015. IPD Sharing: NO. Countries: 1. Publications: 0.
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