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34,558 results for “Therapy”
Hormone Replacement Therapy Social Media Claims
<p>The claims made in social media posts about hormone replacement therapy, the tpye of person/organisation posting these claims, whether the claims agree with NICE/BNF guidance and whether the person/organisation posting these claims has a conflict of interest. Full unredacted dataset available on request to: <a href="mailto:mm494@st-andrews.ac.uk">mm494@st-andrews.ac.uk</a></p>
RNA datasets to derive predictors for immune checkpoint inhibitor therapy of non-small cell lung cancer
<p>Nanostring nCounter datasets and corresponding clinical data of tumor samples of patients with advanced NSCLC who received anti-PD-1 immuntherapy. Prospectively divided into a discovery and a validation cohort.</p> <p>Please cite the corresponding publication in Annals of Oncology (10.1093/annonc/mdz049)</p>
Multi-omics analysis reveals the link between Treg distribution and therapy efficacy in Hepatocellular Carcinoma patients treated with tremelimumab plus durvalumab
<p><strong><span><span>Introduction</span></span></strong></p> <p><span>Hepatocellular carcinoma (HCC) remains a significant contributor to cancer-related deaths. Immunotherapy, either alone or in combination, has emerged as the standard treatment for advanced HCC. Notably, the combination of durvalumab (dur) and tremelimumab (trem) has received FDA approval based on findings from the HIMALAYA trial. However, comprehensive studies elucidating immune responses are lacking. We conducted a thorough analysis utilizing clinical samples from tumor biopsies to understand the mechanism of response.</span></p> <p><strong><span><span>Methods</span></span></strong></p> <p><span>Multiplexed immunofluorescence microscopy was used to analyze immune cell infiltration in primary human liver cancer samples. We developed and validated a comprehensive 37-plex antibody panel for immunofluorescence imaging of human FFPE samples. We applied highly multiplexed co-detection by indexing (CODEX) technology to simultaneously profile in situ expression of 37 proteins at sub-cellular resolution in 20 HCC patient samples using whole slide scanning. We established an image analysis pipeline to quantify all major cell populations in the human liver using supervised manual gating and unsupervised clustering algorithms using the exported matrix of the marker expression and spatial information. Clinical metadata including sex, gender, ethnicity, pretreatment, and histopathological reports are available for all patient samples.</span></p> <p><strong><span><span>Results</span></span></strong></p> <p><span><span>Using high-dimensional spatially resolved quantitative analysis of multiplexed immunofluorescence microscopy images, we generated a unique dataset and profiled the single-cell pathology landscape for human HCC treated with immunotherapy. In situ phenotyping of 400,000 single cells (including 130,000 CD45+ immune cells) allowed for the quantification of cell phenotype clusters, differential analysis of activation markers, and spatial features of each individual cell. This analysis revealed the comprehensive profile of the cell composition and spatial interactions of different cells in the TiME of patients treated with immunotherapy. Further details on the study can be obtained in our paper once it’s published.</span></span></p> <p><strong><span><span>Conclusion</span></span></strong></p> <p><span><span>We developed the CODEX panel for FFPE biopsy samples of HCC patients.</span></span></p>
Backpain exercise therapy remodels human epigenetic profiles in buccal and human peripheral blood mononuclear cells: An exploratory study in young male participants
<pre><strong>###### Files description #####</strong><br> <strong>Notes</strong>. 1) "BT" refers to before therapy and "AT" to after therapy. 2) 0 refers to FALSE and 1 to TRUE for binary variables. The provided files have tab-separated columns except the .RDS which is and R output of the mixOmics DIABLO integration analysis. <strong># Questionnaire</strong> > participants_categories.tsv: per participant (rows), output of the clustering with the participant ("ID") category ("category") per class<br> ("class") > questionnaire_agility_metrics.tsv: questionnaire and agility metrics per participant (rows) for the participants ("ID") with at least one paired AT+BT data in one type of biological sample (indicated in the columns "swab", "PBMC", and "plasma") <strong># PTMs</strong> Samples´ names are encoded as PBMC_AT_8_batch1, i.e. cells origin_time upon therapy_ID_batch (we removed _batch column suffix for the <br>processed files). NA indicates an undetected intensity. > raw_PBMC_light_labelled_intensities.tsv: raw intensity of light/endogenous peptides (row) by precursor per sample (column) from PBMC > raw_swab_light_labelled_intensities.tsv: idem from buccal cells > raw_PBMC_heavy_labelled_intensities.tsv: raw intensity of light/endogenous peptides (row) by precursor per sample (column) from PBMC > raw_swab_heavy_labelled_intensities.tsv: idem from buccal cells > raw_PBMC_heavynormalized_intensities.tsv: raw intensity of light peptides normalized by heavy peptides intensity (row) by precursor per <br>sample (column) > raw_swab_heavynormalized_labelled_intensities.tsv: idem from buccal cells > processed_cleaned_PBMC_log2intensities.tsv: processed (heavy normalized, imputed, batch-corrected) intensity of peptides aggregated by modification (PTM, row) by precursor per sample (column) after log2-transformation. The relative abundances are computed from this file. Rows without me/ac suffix represents the amount of unmodified peptide for the considered site. > processed_cleaned_swab_log2intensities.tsv: idem from buccal cells > rel_abundance_PTM_PBMC.tsv: relative abundance computed per precursor, e.g. for a given sample, the H3_K4+H3_K4me1+H3_K4me2+H3_K4me3 <br>relative abundance values must sum to 100, with the relative abundance of H3_K4 representing the absence of modified K4. > rel_abundance_PTM_swab.tsv: idem from buccal cells > tests_from_rel_abundance_PTM_swab_PBMC.tsv: per type of samples ("Sample.origin", i.e.swab of PBMC) and per PTM (rows, "PTM"), report <br>the output of classic (p-values, adjusted with Benjamini-Hochberg (BH), or Benjamini-Yekutieli procedure (BY), from raw and arcsin square <br>root transformed percentage) and PLS-DA tests (VIP - Variable Importance score - and its 95% confidence interval). The percentage of change<br>of each PTM after therapy relative tobefore therapy is reported in "perc_change.AT.over.BT" column. The "is_candidate" indicates if the PTM has been considered as a hit in the swab or PBMC. <strong># Plasma</strong> Samples´ names are encoded as PLASMA_AT_8_batch1, i.e. cells origin_time upon therapy_ID_batch. NA indicates an undetected intensity. > raw_plasma_maxquant_log2ibaq_intensities.tsv: raw data from protein group MaxQuant file. The iBAQ columns are used in later steps. > processed_cleaned_plasma_log2intensities.tsv: processed (imputed, batch-corrected) intensity of protein groups after log2-transformation. > tests_from_intens_plasma.tsv: per protein group ("Proteins.ID"), report the output of classic (p-values, adjusted Benjamini-Hochberg (BH),<br>or Benjamini-Yekutieli procedure (BY), from log2-transformed intensities) and PLS-DA tests (VIP and its 95% confidence interval). The log2 <br>fold change after therapy relative to before therapy is reported in "log2FC.AT.over.BT" column. The "is_candidate" indicates if the protein group has been considered as a hit. <strong># Integration</strong> > circos_input: output of DIABLO analysis with correlation threshold set to 0.7. Use the readRDS R function to open.</pre> <p> </p>
ValRun: GMP-grade Manufacturing and Quality Control of a Non-Virally engineered Advanced Therapy Medicinal Product for Personalized Treatment of Age-Related Macular Degeneration
<p><strong>VaLRun: </strong></p> <p><strong>Raw data of "GMP-grade Manufacturing and Quality Control of a Non-Virally engineered Advanced Therapy Medicinal Product for Personalized Treatment of Age-Related Macular Degeneration"</strong></p> <p>(Excel-, pdf-, GraphPad-files, mp4 videos and a READ-ME text file)</p> <p>The introduction of new therapeutics requires validation of Good Manufacturing Practice (GMP)-grade manufacturing including suitable quality controls. This is challenging for Advanced Therapy Medicinal Products (ATMP) with personalized batches. We have developed a person-alized, cell-based gene therapy to treat age-related macular degeneration and established a vali-dation strategy of the GMP-grade manufacture for the ATMP; manufacturing and quality control were challenging due to a low cell number, batch-to-batch variability and short production duration. Instead of patient iris pigment epithelial cells, human donor tissue was used to produce the transfected cell product (“tIPE”). We implemented an extended validation of 104 tIPE productions. Procedure, operators and devices have been validated and qualified by determining cell number, viability, extracellular DNA, sterility, duration, temperature and volume. Transfected autologous cells were transplanted to rabbits verifying feasibility of the treatment. A container has been engineered to insure a safe transport from the production to the surgery site. Criteria for successful validation and qualification were based on tIPE’s Critical Quality Attributes and Process Parameters, its manufacture and release criteria. The validated process and qualified operators are essential to bring the ATMP into clinic and offer a general strategy for the transfer to other manufacture centers and personalized ATMPs.</p>
Synthetic magnetic nanoparticles for remote-controlled stemcell therapies of neurodegenerative disorders
<p>In the context of the MAGNEURON european project, we developed different types of magnetic nanoparticles that can act as nanoactuators to manipulate intracellular proteins involved in signaling pathways.</p> <p>Four types of particles are presented here. First, size-sorted maghemite cores of different diameter (8 to 20 nm) were synthesized. Then these cores were used to make Fe2O3@SiO2 core-shell nanoparticles that are colloidally stable and easy to functionalize, and poly(acrylic acid) coated nanoparticles. Both types of particles can be rendered fluorescent by the addition of a fluorophore. Finally, we also developed a way to synthesize micro-needles made of aligned maghemite cores encapsulated in a silica layer.</p> <p>In this dataset are presented some electron microscopy images of the optimized particles and their characterizations in terms of sizes and magnetic properties. These particles have then been used by the other members of the Magneuron consortium in order to manipulate different intracellular signalling pathways.</p>
Raw data acquired necessary to produce the plots introduced in the scientific paper: "Upper-limb kinematic reconstruction during stroke robot-aided therapy" (Medical & Biological Engineering & Computing)
<p>These files contain the raw data acquired necessary to produce the plots introduced the Figure 6 of the scientific paper: “Upper-limb kinematic reconstruction during stroke robot-aided therapy” (Medical & Biological Engineering & Computing).</p> <p>Fig. 6 shows the data recorded from two patients performing five forward/backward movements at InMotion2 robot before and after rehabilitation treatment. Mean values of the five execution have been reported in Fig. 6.</p>
Raw data employed to perform the algorithm used in the scientific paper: "Kinematic reconstruction of the upper limb joints in planar robot-aided therapies
<p>These files contain the raw data (acquired from different users) necessary to perform the algorithm introduced in the scientific paper:</p> <p>PAPER: Kinematic reconstruction of the upper limb joints in planar robot-aided therapies</p> <p>Authors: Arturo Bertomeu-Motos, Ricardo Morales, Jorge A. Díez, Luis D. Lledó, Francisco J. Badesa, Nicolas Garcia-Aracil</p> <p>Conference: ICORR 2015, IEEE 14th International Conference on Rehabilitation Robotics, August 2015</p> <p><br> All the orientations are expressed regarding the origin of the robot.</p> <p>a) Robot Joints: Planar robot joints acquired during the experiment, in radians (j1-j3 columns). This robot is referenced in the paper.<br> b) Quaternion IMU shoulder: Unit quatenion acquired through a 9DoFs Inertial Measurement Unit (IMU) developed by Shimmer (qw1-qz columns).<br> c) Upper arm acceleration: Acceleration acquired from a 3-axial accelerometer developed by Shimmer (X-Z columns). It is normalized regarding the gravity (9.81m/s^2).<br> d) Quaternion Tracker onto Shoulder: unit quaternion of the tracker placed onto the shoulder acquired from the tracking camera V120:trio developed by Optitrack (qw1-qz columns).<br> e) Quaternion Tracker onto Upper Arm: unit quaternion of the tracker placed onto the upper arm acquired from the tracking camera V120:trio developed by Optitrack (qw1-qz columns).</p>
Raw data employed to perform the algorithm used in the scientific paper: "Kinematic reconstruction of the human arm joints in robot-aided therapies with Hermes robot"
<p>This file contains the raw data necessary to perform the algorithm introduced in the scientific paper:</p> <p>PAPER: Kinematic reconstruction of the human arm joints in robot-aided therapies with Hermes robot</p> <p>Authors: Arturo Bertomeu-Motos, Ricardo Morales, Luis D. Lledó, Jorge A. Díez, Jose M. Catalan, Nicolas Garcia-Aracil.</p> <p>Conference: EMBC 2015, IEEE 37th International Conference in Medicine and Biology Society, August 2015.</p> <p>Raw data acquired necessary to perform thee algorithm introduced in this paper.</p> <p>a) Robot Joints: Robot joints generated to develop the simulation, in radians (j1-j7 colums). This robot is referenced in the paper.<br> b) Direct Upper Limb Joints: Upper limb joints generated to develop the simulation, in radians (q1-q7 columns). This data is used to simulate the accelerometer value.</p>
Raw data corresponding to the scientific paper: "A modular telerehabilitation architecture for upper limb robotic therapy" (Advances in Mechanical Engineering 2017, Vol. 9(1) 1-13)
<p>Acquired raw data necessary to implement the adaptive control strategy grounded on multimodal information.<br> In addition, raw data for the computation of the communication parameters needed for the assessment of the implemented telerehabilitation architecture are provided.</p> <p>a) End-effector positions and velocities (x, y, vx, vy) in three conditions: healthy (Fig 9) and constraint simulated stroke behaviour (Fig 10) without robotic assistance and simulated stroke behavior with robotic assistance (Fig 11)</p> <p>b) Performance indicators and control parameters for all the recruited subjects in both conditions healthy behaviour and simulated stroke behaviour (Fig 12a and Fig 12b)</p> <p>c) Computational values for evaluating telerehabilitation performance (Table 1)</p> <p> </p> <p> </p>
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor therapy reduces the level of DNA damage in patients with heterozygous familial hypercholesterolemia
<p><span><span>Heterozygous Familial Hypercholesterolaemia (HeFH) is a common autosomal dominant genetic disease (1:300) characterized by elevated LDL-C leading to premature atherosclerosis. Treatment with a PCSK9 inhibitor (iPCSK9) is recommended in high cardiovascular risk FH patients if the treatment goal is not achieved on maximal tolerated statin plus ezetimibe. </span></span><span>The aim of this study was to </span><span><span>examine the changes in DNA damage in HeFH patients associated with iPCSK9 use. </span></span><span>Fifty-seven patients were included: a normolipidemic group (control; n=20) and patients with HeFH (study group; n=36). DNA damage was determined by alkaline comet assay. PCSK9 protein level was assessed by ELISA. </span><span>The levels of Lp(a) in human serum were quantitatively turbidimetrically assay.</span><span> </span><span>PCSK9i treatment was associated with lower DNA damage, Lp(a), PCSK9 and lipid profile than before treatment. However, 20 of 36 patients still had Lp(a) values above 125 nmol/L, and reduced Lp(a) did not correlate with reduced DNA damage. Reduced PCSK9 moderately (r=0.48) correlates with reduced DNA damage</span><span><span>. PCSK9i therapy reduces the level of DNA damage in HeFH patients, regardless of the type of inhibitor. The reduction in DNA damage is not related to the changes in lipid profile or Lp(a) induced by PCSK9i, but it is dependent on PCSK9 level.</span></span></p>
Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid - preventive therapies for people living with HIV.
<p>This is the minimal data set underlying the findings of our systematic review and metasummary:</p> <p>We uploaded the following data extracted from the studies included in our review:</p> <p>- Systematic Review protocol, also published in PROSPERO (CRD42019137778).</p> <p>- detailed description of studies included in our review.</p> <p>- barriers identified in the review (metasummary).</p> <p>- facilitators identified in the review.</p>
The repurposing of tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug resistant Shigella spp.
<p><strong>dataset for The repurposing of tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug resistant <em>Shigella</em> spp.</strong></p> <p>Elena Fernández Alvaro <sup>1*</sup>, Phat Voong Vinh <sup>2</sup>, Cristina de Cozar <sup>1</sup>, David Wille <sup>1</sup>, Beatriz Urones <sup>1</sup>,</p> <p>Alan Price <sup>1</sup>, Nhu Tran Do Hoang <sup>2</sup>, Tuyen Ha Thanh <sup>2</sup>, Molly McCloskey <sup>3</sup>, Shareef Shaheen<sup> 3</sup>, Denise Dayao<sup> 4</sup>, Jaime de Mercado <sup>1</sup>, Pablo Castañeda <sup>1</sup>, Adolfo García-Perez <sup>1</sup>, Benson Singa <sup>5</sup>, Patricia Pavlinac <sup>6</sup>,</p> <p>Judd Walson<sup>3</sup>, Maria Santos Martínez-Martínez <sup>1</sup>, Samuel L.M. Arnold <sup>3</sup>, Tzipori Saul <sup>4</sup>, Lluis Ballell <sup>1#</sup>,</p> <p>and Stephen Baker <sup>7,8*</sup></p> <p> </p>
A database of physical therapy exercises with variability of execution collected by wearable sensors
<p>The PHYTMO database contains data from physical therapy exercises and gait variations recorded with magneto-inertial sensors, including information from an optical reference system. PHYTMO includes the recording of 30 volunteers, aged between 20 and 70 years old. A total amount of 6 exercises and 3 gait variations commonly prescribed in physical therapies were recorded. The volunteers performed two series with a minimum of 8 repetitions in each one. Four magneto-inertial sensors were placed on the lower-or upper-limbs for the recording of the motions together with passive optical reflectors. The files include the specifications of the inertial sensors and the cameras. The database includes magneto-inertial data (linear acceleration, turn rate and magnetic field), together with a highly accurate location and orientation in the 3D space provided by the optical system (errors are lower than 1mm). The database files were stored in CSV format to ensure usability with common data processing software. The main aim of this dataset is the availability of inertial data for two main purposes: the analysis of different techniques for the identification and evaluation of exercises monitored with inertial wearable sensors and the validation of inertial sensor-based algorithms for human motion monitoring that obtains segments orientation in the 3D space. Furthermore, the database stores enough data to train and evaluate Machine Learning-based algorithms. The age range of the participants can be useful for establishing age-based metrics for the exercises evaluation or the study of differences in motions between different aged groups. Finally, the MATLAB function <em>features_extraction</em>, developed by the authors, is also given. This function splits signals using a sliding window, returning its segments, and extract signal features, in the time and frequency domains, based on prior studies of the literature.</p>
Multi-omic machine learning predictor of breast cancer therapy response
<p>H&E slides used in the training dataset described in "Multi-omic machine learning predictor of breast cancer therapy response" published in <em>Nature</em>: <a href="https://www.nature.com/articles/s41586-021-04278-5">https://www.nature.com/articles/s41586-021-04278-5</a></p> <p>Metadata associated with these images also included in file Slide metadata.xlsx</p>
Population size, HIV prevalence, and antiretroviral therapy coverage among key populations in sub-Saharan Africa: collation and synthesis of survey data 2010-2023
<p>This dataset contains surveillance study estimates for population size, HIV prevalence, and ART coverage among female sex workers (FSW), men who have sex with men (MSM), people who inject drugs (PWID), and transgender men and women (TGM/W) from 2010-2023. It was created to support the UNAIDS Estimates Key Population Workbook for use by HIV estimates teams in sub-Saharan Africa. Key population surveillance reports, including Ministry of Health-led biobehavioural surveys, mapping studies, and academic studies were used to populate the database.</p> <p>The dataset was populated using existing key population size estimate databases including:</p> <ul> <li>UNAIDS Key Population Atlas</li> <li>US Centers for Disease Control and Prevention surveillance database</li> <li>Global Fund against HIV/AIDS, TB, and Malaria surveillance database</li> <li>Global.HIV database</li> <li>Systematic review databases among MSM (<a href="https://pubmed.ncbi.nlm.nih.gov/31601542/" target="_blank" rel="noopener">Stannah et al, 2019</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/37453439/" target="_blank" rel="noopener">Stannah et al., 2023</a>) and PWID (<a href="https://pubmed.ncbi.nlm.nih.gov/36996857/" target="_blank" rel="noopener">Degenhardt et al., 2023</a>)</li> </ul> <p><br>and was additionally supplemented by a literature review of peer-reviewed and grey literature sources.</p> <p>The data can be <a href="https://shiny.dide.ic.ac.uk/kp-data/" target="_blank" rel="noopener">explored in this web application</a> and the <a href="https://www.medrxiv.org/content/10.1101/2022.07.27.22278071v3" target="_blank" rel="noopener">accompanying manuscript can be found here</a></p>
Conventional therapy induces tumor immunoediting and modulates the immune contexture in colorectal cancer
<p>Cancer immunotherapies for patients with colorectal cancer (CRC) continue to lag behind other solid cancer types with the exception of 4% of patients with microsatellite-instable tumors. Thus, there is an urgent need to broaden the clinical benefit of checkpoint blockers to CRC by combining conventional therapies to sensitize tumors to immunotherapy. However, the impact of conventional drugs on immunoediting and hence, imposing positive selection towards less immunogenic variants, and on the tumor immune contexture in CRC remains elusive.</p> <p>In this study, we performed comprehensive multimodal profiling using longitudinal samples from metastatic CRC patients undergoing neoadjuvant therapy with mFOLFOX6 and Bevacizumab. Exome-sequencing, RNA-sequencing and multiplexed immunofluorescence imaging was carried out on tumor samples obtained before and after therapy and the data was analyzed using established methods. The results of the analysis were extrapolated to publicly available datasets (TCGA and CPTAC). In order to identify a surrogate marker, an explainable artificial intelligence method was developed using a transformer-based analytical pipeline for the identification of features in H&E images associated with specific biological processes, followed by manual evaluation of highly informative tiles by a pathologist.</p> <p>We expect that the results of this project will provide a deeper understanding of the tumor-immune interactions and will allow the development of more robust combinatorial therapeutic strategies for MSS CRC.</p>
Virtual reality exposure therapy for social anxiety_Premkumar et al 2024
<p>The dataset from the project titled "Augmenting virtual-reality exposure therapy for social anxiety with biofeedback: a randomised controlled trial"</p>
Dataset for "Cognitive behavioural therapy self-help intervention preferences among informal caregivers of adults with chronic kidney disease: an online cross-sectional survey"
<p>Data and R code used for the analysis of data for the publication: Coumoundouros et al., Cognitive behavioural therapy self-help intervention preferences among informal caregivers of adults with chronic kidney disease: an online cross-sectional survey. BMC Nephrology</p> <p><strong>Summary of study</strong></p> <p>An online cross-sectional survey for informal caregivers (e.g. family and friends) of people living with chronic kidney disease in the United Kingdom. Study aimed to examine informal caregivers' cognitive behavioural therapy self-help intervention preferences, and describe the caregiving situation (e.g. types of care activities) and informal caregiver's mental health (depression, anxiety and stress symptoms).</p> <p>Participants were eligible to participate if they were at least 18 years old, lived in the United Kingdom, and provided unpaid care to someone living with chronic kidney disease who was at least 18 years old.</p> <p>The online survey included questions regarding (1) informal caregiver's characteristics; (2) care recipient's characteristics; (3) intervention preferences (e.g. content, delivery format); and (4) informal caregiver's mental health. Informal caregiver's mental health was assessed using the 21 item Depression, Anxiety, and Stress Scale (DASS-21), which is composed of three subscales measuring depression, anxiety, and stress, respectively.</p> <p>Sixty-five individuals participated in the survey.</p> <p>See the published article for full study details.</p> <p><strong>Description of uploaded files</strong></p> <p>1. ENTWINE_ESR14_Kidney Carer Survey Data_FULL_2022-08-30: Excel file with the complete, raw survey data. Note: the first half of participant's postal codes was collected, however this data was removed from the uploaded dataset to ensure participant anonymity.</p> <p>2. ENTWINE_ESR14_Kidney Carer Survey Data_Clean DASS-21 Data_2022-08-30: Excel file with cleaned data for the DASS-21 scale. Data cleaning involved imputation of missing data if participants were missing data for one item within a subscale of the DASS-21. Missing values were imputed by finding the mean of all other items within the relevant subscale. </p> <p>3. ENTWINE_ESR14_Kidney Carer Survey_KEY_2022-08-30: Excel file with key linking item labels in uploaded datasets with the corresponding survey question.</p> <p>4. R Code for Kidney Carer Survey_2022-08-30: R file of R code used to analyse survey data.</p> <p>5. R code for Kidney Carer Survey_PDF_2022-08-30: PDF file of R code used to analyse survey data.</p>
Clonal heterogeneity of endocrine therapy resistance in breast cancer
<p>We barcoded endocrine therapy sensitive cell lines (MCF7 and T47D) and rendered them resistant to commonly applied first line endocrine therapeutics (Tamoxifen and estrogen deprivation). Next, we isolated single cell clones of endocrine therapy resistant populations and subjected clonal cell lines to RNA-Seq and Phosphoproteomics profiling.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.