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4 results for “Thermal Sensation”
Thermal Sensation Classification Dataset based on ASHRAE Global Thermal Comfort Database II
<p><span>The dataset is based on ASHRAE Global Thermal Comfort Database II (version 2.01), which includes sets of objective indoor and outdoor climatic observations with accompanying “<em>right-here-right-now</em>” subjective evaluations by the building occupants. Data rows lacking information for any of the selected variables from the original dataset were excluded. Consequently, the dataset contains 10,618 data rows. Description of individual variables in the dataset are as follows:</span></p> <p><span><span>·<span> </span></span></span><span>Tair: Air temperature measured in the occupied zone (°C) ranging from 13.4 to 45.3 with 10,618 data points.</span></p> <p><span><span>·<span> </span></span></span><span>Vair: Air speed in the occupied zone (m/s) ranging from 0 to 4.71.</span></p> <p><span><span>·<span> </span></span></span><span>Relative Humidity (RH): Relative humidity in the occupied zone (%) ranging from 14.5 to 88.8.</span></p> <p><span><span>·<span> </span></span></span><span>SET: Standard Effective Temperature in Celsius (°C) ranging from 10.93 to 38.94.</span></p> <p><span><span>·<span> </span></span></span><span>CLO: Intrinsic clothing ensemble insulation of the occupant (clo) ranging from 0.23 to 2.87.</span></p> <p><span><span>·<span> </span></span></span><span>MET: Average metabolic rate of the occupant (met) ranging from 0.7 to 3.5.</span></p> <p><span><span>·<span> </span></span></span><span>Age: Age of the occupants ranging from 16 to 95 years.</span></p> <p><span><span>·<span> </span></span></span><span>Sex: Sex of the occupants, categorized as Male or Female.</span></p> <p><span><span>·<span> </span></span></span><span>Tout: Outdoor monthly average temperature during the field study (°C) ranging from 5.3 to 38.1.</span></p> <p><span><span>·<span> </span></span></span><span>Season: Season during which the study was conducted, categorized as Spring, Summer, Autumn, or Winter.</span></p> <p><span><span>·<span> </span></span></span><span>Building Operation Mode: Can be Air Conditioned (air, radiant, etc., with no operable windows), Naturally Ventilated (no mechanical cooling, with operable windows), or Mixed Mode (mechanical cooling and operable windows, with concurrent, changeover, or zoned control).</span></p> <p><span><span>·<span> </span></span></span><span>Building type: Type of building where the study was conducted, categorized as Classroom, Office, or Senior Center.</span></p> <p><span><span>·<span> </span></span></span><span>Thermal Sensation Vote (TSV): ASHRAE Thermal Sensation Vote of the occupant, ranging from -3 (cold) to +3 (hot).</span></p>
Genetic Variants and Chemotherapy-induced Abnormal Thermal Sensation
ClinicalTrials.gov study NCT03252834. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Distinct BOLD fMRI responses of capsaicin-induced thermal sensation reveal pain-related brain activation in nonhuman primates
Background: Approximately 20% of the adult population suffer from chronic pain that is not adequately treated by current therapies, highlighting a great need for improved treatment options. To develop effective analgesics, experimental human and animal models of pain are critical. Topically/intra-dermally applied capsaicin induces hyperalgesia and allodynia to thermal and tactile stimuli that mimics chronic pain and is a useful translation from preclinical research to clinical investigation. Many behavioral and self-report studies of pain have exploited the use of the capsaicin pain model, but objective biomarker correlates of the capsaicin augmented nociceptive response in nonhuman primates remains to be explored. Methodology: Here we establish an aversive capsaicin-induced fMRI model using non-noxious heat stimuli in Cynomolgus monkeys (n = 8). BOLD fMRI data were collected during thermal challenge (ON:20 s/42°C; OFF:40 s/35°C, 4-cycle) at baseline and 30 min post-capsaicin (0.1 mg, topical, forearm) application. Tail withdrawal behavioral studies were also conducted in the same animals using 42°C or 48°C water bath pre- and post- capsaicin application (0.1 mg, subcutaneous, tail). Principal Findings: Group comparisons between pre- and post-capsaicin application revealed significant BOLD signal increases in brain regions associated with the 'pain matrix', including somatosensory, frontal, and cingulate cortices, as well as the cerebellum (paired t-test, p<0.02, n = 8), while no significant change was found after the vehicle application. The tail withdrawal behavioral study demonstrated a significant main effect of temperature and a trend towards capsaicin induced reduction of latency at both temperatures. Conclusions: These findings provide insights into the specific brain regions involved with aversive, 'pain-like', responses in a nonhuman primate model. Future studies may employ both behavioral and fMRI measures as translational biomarkers to gain deeper understanding of pain processing and evaluate the preclinical efficacy of novel analgesics.
Data from: Distinct BOLD fMRI responses of capsaicin-induced thermal sensation reveal pain-related brain activation in nonhuman primates
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