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137 results for “Thymic epithelial cells”
scRNA-seq of thymic epithelial cells from Aire-knockout rats
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Transcriptome profiling of medullary thymic epithelial cells from Aire-knockout rats
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Data from: Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development
MicroRNAs (miRNAs) have been shown to be key modulators of post-transcriptional gene silencing in many cellular processes. In previous studies designed to understand the role of miRNAs in thymic development, we globally deleted miRNA exclusively in thymic epithelial cells (TECs), which are critical in thymic selection. This resulted in the loss of stromal cells that instruct T cell lineage commitment and affect thymocyte positive selection, required for mature T cell development. Since murine miR-181 is expressed in the thymus and miR-181 deficiency disrupts thymocyte development, we first quantified and thereby demonstrated that miR181a1 and miR181b1 are expressed in purified TECs. By generating mice with TEC targeted loss of miR-181a1 and miR-181b1 expression, we observed that neither TEC cellularity nor thymocyte number nor differentiation was adversely affected. Thus, disrupted thymopoiesis in miR-181 deficient mice was not due to miR-181 loss of expression in TECs. Importantly, in mice with restricted TEC deficiency of miR-181a1 and miR-181b1, there were similar numbers of mature T cells in the periphery in regards to frequencies, differentiation, and function as compared to controls. Moreover miR-181a1 and miR-181b1 were not required for maintenance of thymus integrity over time, as thymic involution was not accelerated in gene-targeted mice. Taken together our data indicate that miR-181a1 and miR-181b1 are dispensable for TEC differentiation, their control of thymocyte development and mature T cell export to and homeostasis within the periphery.
Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial
ClinicalTrials.gov study NCT02146170. IPD Sharing: YES. Countries: 1. Publications: 4.
Data from: Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development
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mTORC1 in thymic epithelial cells is critical for thymopoiesis, T-cell generation, and temporal control of gdT17 development and TCRg/d recombination
<p>FCS Files for Fig 1 to Fig 11</p>
Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells
GEO Series GSE194253. Mus musculus. 82 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Age-related epithelial defects limit thymic function and regeneration [single cell; Foxn1Lin]
GEO Series GSE249753. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Promiscuous gene expression in human medullary thymic epithelial cell subsets
GEO Series GSE49625. Homo sapiens. 26 samples. Type: Expression profiling by array.
Rbfox contributes to a conservative program of self-antigen splicing in thymic epithelial cells [mTEC_bulk_RNAseq]
GEO Series GSE145930. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Third-party reanalysis.
microRNA expression in thymic epithelial cells
GEO Series GSE68674. Mus musculus; synthetic construct. 8 samples. Type: Non-coding RNA profiling by array.
Characterization of Fetal Specific Transcriptional Programs in Thymic Epithelial Cells Identifies Myc as a Critical Determinant of Thymus Size
GEO Series GSE131368. Mus musculus. 61 samples. Type: Expression profiling by high throughput sequencing.
Thymic epithelial cell alterations and defective thymopoiesis lead to central and peripheral tolerance perturbation in MHCII deficiency
GEO Series GSE166463. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Sex hormones have pervasive effects on thymic epithelial cells
GEO Series GSE66873. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
Age-related epithelial defects limit thymic function and regeneration [single cell; Foxn1LacZ]
GEO Series GSE249752. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Thymic epithelial organoids mediate T cell development [Bulk RNA-seq]
GEO Series GSE240696. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Characterization of Fetal Specific Transcriptional Programs in Thymic Epithelial Cells Identifies Myc as a Critical Determinant of Thymus Size [bulk RNA-Seq]
GEO Series GSE129192. Mus musculus. 51 samples. Type: Expression profiling by high throughput sequencing.
Klf6 is required in thymic epithelial cells for normal thymus development [scRNA-seq]
GEO Series GSE220270. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional regulation by Aire in medullary thymic epithelial cells revisited
GEO Series GSE155331. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
RNA-seq profiling of epithelial cells from fetal thymic organ cultures from Kat7 knockout and wildtype mice
GEO Series GSE188869. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.