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42 results for “Thyroid dysfunction”
Comparative proteomic and metabolomic analyses of plasma reveal the novel biomarker panels for thyroid dysfunction
<p><strong>Abstract</strong><strong>:</strong></p> <p><em>Objectives: </em>Thyroid dysfunction such as hypothyroidism (THO) and hyperthyroidism (THE) are the disease caused by pathological processes in the thyroid. The current diagnosis of thyroid dysfunction is variable because of ages and genders. The aim of this study was to explore the novel candidate biomarker panels for hypothyroidism and hyperthyroidism screening with mass spectrometry and bioinformatics.</p> <p><em>Methods:</em> Plasma samples were collected from 15 THE patients, 9 THO patients, and 15 healthy controls. DIA-based proteomic and untargeted metabolomic analyses were performed to identify the novel biomarker panels for THO and THE. Finally, three candidate biomarkers were verified by ELISA in 34 samples.</p> <p><em>Results:</em> A total of 2738 proteins and 6103 metabolites were identified, and 173 proteins and 2487 metabolites were found to be differentially expressed among THE, THO and control groups. The results of the ensemble feature selection, K-means clustering and the least absolute shrinkage and selection operator (LASSO) regression model showed that four proteins (C4A, C3/C5 convertase, APOL1, and ITIH4) and four metabolites (L-arginine, L-proline, cortisol, and cortisone) identified by plasma proteomics and metabolomics could help distinguish THO and THE patients from healthy controls.</p> <p><em>Conclusions:</em> This study identified and verified two pairs of biomarker panels that can distinguish the THE and THO patients regardless of ages and genders. Consequently, our findings represent a comprehensive analyses of thyroid dysfunction plasma, which is significant for the clinical diagnosis.</p> <p> </p>
Immunotherapy-mediated thyroid dysfunction: genetic risk and impact on outcomes with PD-1 blockade in non-small cell lung cancer
<p>Polygenic risk score weights derived using LDpred for hypothyroidism and thyroid medication use.</p>
EEG Alterations in Preterm Infants With Thyroid Dysfunction
ClinicalTrials.gov study NCT03493113. IPD Sharing: NO. Countries: 1. Publications: 19.
Thyroid Dysfunction Induced by Anti-PD-1 Therapy in Patients With Advanced Carcinoma
ClinicalTrials.gov study NCT05593744. IPD Sharing: NO. Countries: 1. Publications: 1.
Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction
ClinicalTrials.gov study NCT02491008. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Thyroid Dysfunction in Female Patients With Acne Vulgaris: [ Relation to Other Variables ]
ClinicalTrials.gov study NCT03602534. IPD Sharing: UNDECIDED. Countries: 1. Publications: 11.
Evaluation of the Pattern of Thyroid Dysfunctions in Patients With Metabolic Syndrome
ClinicalTrials.gov study NCT03214068. IPD Sharing: NO. Countries: 1. Publications: 1.
Evaluation of Different Psychiatric Symptoms in Patients With Thyroid Dysfunction
ClinicalTrials.gov study NCT06185309. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Thyroid Dysfunction in Patients With Nephrotic Syndrome
ClinicalTrials.gov study NCT04323007. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Impact Of Thyroid Dysfunction on Liver Function Tests
ClinicalTrials.gov study NCT07354048. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Thyroid Dysfunction in Patients With Major Psychiatric Disorders
ClinicalTrials.gov study NCT06293534. IPD Sharing: UNDECIDED. Countries: 0. Publications: 6.
Thyroid Dysfunction in Head and Neck Surgery Patients
ClinicalTrials.gov study NCT00592514. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Relationship Between Thyroid Dysfunction and Diabetes
ClinicalTrials.gov study NCT07099937. IPD Sharing: UNDECIDED. Countries: 0. Publications: 4.
The Prevalence and Risk Factors for Thyroid Dysfunction in Pregnant Women in Taiwan
ClinicalTrials.gov study NCT04936698. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Thyroid Dysfunction in Women With Newly Diagnosed Breast Cancer Compared to Healthy Volunteers
ClinicalTrials.gov study NCT00336102. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Thyroid Dysfunction in Patients With Type 2 Diabetes With Early Diabetic Nephropathy.
ClinicalTrials.gov study NCT03154398. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of Nutrition Education on the Quality of Life, Chronic Disease Adaptation in Patients With Thyroid Dysfunction
ClinicalTrials.gov study NCT07027579. IPD Sharing: NO. Countries: 1. Publications: 0.
Development of an AI Solution to Evaluate Clinical Activity of TAO Using Periocular Images Taken by Smartphones in Patients With Thyroid Dysfunction
ClinicalTrials.gov study NCT05731154. IPD Sharing: NO. Countries: 1. Publications: 0.
Interleukin-6 and Thyroid Dysfunction in Hemodialysis Patients
ClinicalTrials.gov study NCT07328113. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of Teprotumumab on Thyroid Eye Disease and Thyroid Dysfunction
ClinicalTrials.gov study NCT06275373. IPD Sharing: NO. Countries: 1. Publications: 0.
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