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4 results for “Time-Domain Diffuse Optics”
Interstitial null-distance time-domain diffuse optical spectroscopy using a superconducting nanowire detector
<p>We demonstrate a novel realization of Interstitial fiber, broadband, Time Domain Diffuse Optical Spectroscopy (TD-DOS) in Null Source-Detector separation (NSDS) approach without temporal gating, by using a Superconducting Nanowire single photon detector (SNSPD) for acquisition. As per the MEDPHOT protocol, we test experimentally, the absorption linearity of the system on tissue-equivalent liquid phantoms, and demonstrate the scattering-independent retrieval of the absorption spectrum of water using Intralipid phantoms in the wavelength range of 600-1100 nm.</p> <p>This work has been published in the Journal of Biomedical Optics - https://doi.org/10.1117/1.JBO.28.12.121202. Here, we present the dataset containing the acquired data pertaining to the aforementioned publication, including a brief overview, the tools to read it and the analysis corresponding to the figures in the article.</p>
Dataset: Use of bioresorbable fibers for short-wave infrared spectroscopy using time-domain diffuse optics
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Dataset of "Optical Signatures of Thermal Damage on ex-vivo Brain, Lung and Heart Tissues using Time-Domain Diffuse Optical Spectroscopy"
<p>Dataset for the article entitled "Optical Signatures of Thermal Damage on ex-vivo Brain, Lung and Heart Tissues using Time-Domain Diffuse Optical Spectroscopy" </p> <p> </p> <p>Abstract:</p> <p> </p> <p>Thermal Therapies treat tumors by means of heat, greatly reducing pain, post-operation complications, and cost as compared to traditional methods. Yet, effective tools to avoid under- or over-treatment are mostly needed, to guide surgeons in laparoscopic interventions.<br>In this work, we investigated the temperature-dependent optical signatures of ex-vivo calf brain, lung, and heart tissues, based on the reduced scattering and absorption coefficients in the near-infrared spectral range (657 to 1107 nm). These spectra were measured by time domain diffuse optics, applying a step-like spatially homogeneous thermal treatment at 43 °C, 60 °C, and 80 °C.<br>We found three main increases in scattering spectra, possibly due to the denaturation of collagen, myosin, and proteins secondary structure.<br>After 75 °C, we found the rise of two new peaks at 770 and 830 nm in the absorption spectra due to the formation of a new chromophore, possibly related to hemoglobin or myoglobin.<br>This research marks a significant step forward in controlling thermal therapies with diffuse optical techniques by identifying several key markers of thermal damage. This could enhance the ability to monitor and adjust treatment in real-time, promising improved outcomes in tumor therapy.</p> <p> </p> <p> </p> <p>Authors:</p> <p>ALESSANDRO BOSSI , LEONARDO BIANCHI , PAOLA SACCOMANDI , AND ANTONIO PIFFERI<br>Politecnico di Milano</p> <p> </p> <p> </p> <p><a href="https://opg.optica.org/boe/fulltext.cfm?uri=boe-15-4-2481&id=548108" target="_blank" rel="noopener">Link to the article</a></p>
DATA SET: Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies
<p>This repository contains the data sets of the article:</p> <p>P. Fernández Esteberena et al. (2024). Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies. <em>Biomedical Optics Express</em>. <a href="https://doi.org/10.1364/BOE.538141">https://doi.org/10.1364/BOE.538141</a></p>
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