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145 results for “Transdifferentiation”
Effect of astragalus injection on renal tubular epithelial transdifferentiation in type 2 diabetic mice
<p><strong>Background</strong>: Astragalus injection is used by practitioners of traditional Chinese medicine to treat diabetic nephropathy (DN). The current study was conducted to determine the effect of astragalus on tubular epithelial transdifferentiation during the progression of DN in KKAy mice, as well as to investigate the molecular mechanism underlying this effect.</p> <p> </p> <p><strong>Methods: </strong>Diabetic, 14-week-old, male KKAy mice were randomly divided into a model group and an astragalus treatment group, while age-matched male C57BL/6J mice were selected as controls. The treatment group received daily intraperitoneal injections of astragalus (0.03 mL/10 g per day), while the model group received injections of an equal volume of saline. Mice were euthanized after 24 weeks. Serum samples were obtained from the animals in each group for blood glucose measurement. Kidney tissue samples were used for morphometric studies. The mRNA and protein expression levels of transforming growth factor beta 1 (TGF-β1), transforming growth factor beta receptor 1 (TGFβ-R1), alpha smooth muscle actin (α-SMA), and E-cadherin were evaluated using real-time polymerase chain reaction (PCR) and western blotting.</p> <p> </p> <p><strong>Results: </strong>Astragalus significantly reduced blood glucose levels; inhibited morphological changes in the kidneys of KKAy mice; reduced mRNA and protein expression levels of TGF-β1, TGFβ-R1, and α-SMA; and increased E-cadherin expression.</p> <p> </p> <p><strong>Conclusions:</strong> Tubular epithelial transdifferentiation plays an important role in the development of DN in diabetic mice. Administration of astragalus likely prevents or mitigates DN by suppressing tubular epithelial transdifferentiation, protecting KKAy mice from renal damage.</p>
Data from: A novel mechanism of gland formation in zebrafish involving transdifferentiation of renal epithelial cells and live cell extrusion
Transdifferentiation is the poorly understood phenomenon whereby a terminally differentiated cell acquires a completely new identity. Here, we describe a rare example of a naturally occurring transdifferentiation in zebrafish in which kidney distal tubule epithelial cells are converted into an endocrine gland known as the Corpuscles of Stannius (CS). We find that this process requires Notch signalling and is associated with the cytoplasmic sequestration of the Hnf1b transcription factor, a master-regulator of renal tubule fate. A deficiency in the Irx3b transcription factor results in ectopic transdifferentiation of distal tubule cells to a CS identity but in a Notch-dependent fashion. Using live-cell imaging we show that CS cells undergo apical constriction en masse and are then extruded from the tubule to form a distinct organ. This system provides a valuable new model to understand the molecular and morphological basis of transdifferentiation and will ad vance efforts to exploit this rare phenomenon therapeutically.
Data from: A novel mechanism of gland formation in zebrafish involving transdifferentiation of renal epithelial cells and live cell extrusion
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CXCR4-LASP1-G9a-SNAIL Axis Drives NEPC Transdifferentiation via Induction of EMT and Downregulation of REST [331R]
GEO Series GSE296569. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide integration of microRNA and the transcriptome during human alveolar epithelial cell transdifferentiation identifies SGK1 as novel target of miR- 424/503
GEO Series GSE140073. Homo sapiens. 27 samples. Type: Non-coding RNA profiling by array; Expression profiling by high throughput sequencing.
Time course of mesenchymal breast cancer cells (MTΔECad) undergoing transdifferentiation into terminally differentiated adipocytes
GEO Series GSE89553. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Ribosome incorporation transdifferentiates chick primary cells and induces their proliferation by secreting growth factors
GEO Series GSE289409. Gallus gallus. 4 samples. Type: Expression profiling by high throughput sequencing; Other.
Generating iAstrocytes from hiPSCs by combining low-density passaging of NPCs and NFIA transdifferentiation
GEO Series GSE273666. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Cancer-associated Fibroblast Induces Acinar-to-ductal Cell Transdifferentiation and Pancreatic Cancer Initiation via LAMA5/ITGA4 axis
GEO Series GSE249567. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Fosl1 transdifferentiate embryonic stem cells to differentiated trophoblast stem cells. (ChIP-seq)
GEO Series GSE99983. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Artemisinins target GABA receptor signaling to induce alpha to beta cell transdifferentiation
GEO Series GSE84714. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Programmed genomic instability regulates neural transdifferentiation of human brain microvascular pericytes [DRIP-Seq]
GEO Series GSE187018. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
EIF6 conditions drug-tolerant persister-like transdifferentiation in small cell lung carcinoma (eIF6_KD)
GEO Series GSE262596. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
A decision-point between programmed cell death and transdifferentiation in pancreatic cancer
GEO Series GSE275488. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Dynamic epigenetic remodeling underlies microRNA-mediated transdifferentiation of human adult fibroblasts into neuronal subtypes
GEO Series GSE102035. Homo sapiens. 42 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Expression profiling by array.
Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy [RNAseq_ip63]
GEO Series GSE242463. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Next-generation sequencing of human dermal fibroblasts transdifferentiated towards the otic lineage
GEO Series GSE108905. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte-transdifferentiation
GEO Series GSE317739. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
KMT2B is selectively required for neuronal transdifferentiation [RNAseq]
GEO Series GSE120440. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming.
GEO Series GSE112004. Mus musculus. 3840 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.