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33 results for “Trichophyton”
Discovery of new Trichophyton members, T. persicum and T. spiraliforme spp. nov., as a cause of highly inflammatory tinea cases in Iran and Czechia
<p>Pathogens from the <i>Trichophyton benhamiae</i> complex are one of the most important causes of animal mycoses with significant zoonotic potential. In the light of the recently revised taxonomy of this complex, we retrospectively identified 38 <i>Trichophyton</i> isolates that could not be resolved in any of the existing species. These strains were isolated from Iranian and Czech patients during molecular epidemiological surveys on dermatophytosis and were predominantly associated with highly inflammatory tinea corporis cases suggesting possible zoonotic etiology. Subsequent phylogenetic (4 markers), population-genetic (10 markers) and phenotypic analyses supported recognition of two novel species. The first species, <i>T.</i> <i>persicum </i>sp. nov., was identified in 36 cases of human dermatophytosis and one case of feline dermatophytosis, mainly in Southern and Western Iran. The second species, <i>T. spiraliforme </i>sp. nov., is only known from a single case of tinea corporis in a Czech patient who probably contracted the infection from a dog. Although the zoonotic source of infections summarized in this study is very likely, little is known about the host spectrum of these pathogens. Awareness of these new pathogens among clinicians should refine our knowledge about their poorly explored geographic distribution.</p>
Data for: Defining the relationship between phylogeny, clinical manifestation and phenotype for Trichophyton mentagrophytes/interdigitale complex; a literature review and taxonomic recommendations
<p><span>This study looked for correlations between molecular identification, clinical manifestation and morphology for <em>Trichophyton interdigitale</em> and <em>T. mentagrophytes</em>. For this purpose, a total of 110 isolates were obtained from Czech patients with various clinical manifestations of dermatophytosis. Micro- and macromorphology and physiology were analysed, and the strains were characterized using multilocus sequence typing. Among the 12 measured/</span><span>scored phenotypic features, statistically significant differences between species were found only in growth rates at 37°C and in</span><span> the</span><span> production of spiral hyphae but none of these features was diagnostic. </span><span>Correlations were found between <em>T. interdigitale</em> and higher age of patients and between clinical manifestations such as tinea pedis or onychomychosis.</span><span> </span><span>The MLST approach showed that ITS genotyping of <em>T. mentagrophytes</em> isolates has limited practical benefits because of extensive gene flow between sublineages. Based on our results and previous studies, there are few taxonomic arguments for preserving both species' names. The species show a lack of monophyly and unique morphology. On the other hand, some genotypes are associated with predominant clinical </span><span>manifestations and sources</span><span> of infections</span><span>,</span><span> which keep those names alive. This practice is questionable because the use of both names confuses identification</span><span>,</span><span> leading to difficulty in comparing epidemiological studies. The current identification method using ITS genotyping is ambiguous for some isolates and is not user-friendly. Additionally, identification tools such as MALDI-TOF MS fail to distinguish these species. To avoid further confusion and simplify identification in practice, we recommend using the name <em>T. mentagrophytes</em> for the entire complex. When clear differentiation of populations corresponding to <em>T. interdigitale</em> and <em>T. indotineae</em> is possible based on molecular data, we recommend optionally using a variety rank:<em> T. mentagrophytes</em> var. <em>interdigitale</em> and <em>T. mentagrophytes</em> var. <em>indotineae</em>.</span></p>
Discovery of new Trichophyton members, T. persicum and T. spiraliforme spp. nov., as a cause of highly inflammatory tinea cases in Iran and Czechia
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Data for: Defining the relationship between phylogeny, clinical manifestation and phenotype for Trichophyton mentagrophytes/interdigitale complex; a literature review and taxonomic recommendations
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Data from: Resolving phylogenetic relationships within the <em>Trichophyton mentagrophytes</em> complex: A RADseq genomic approach challenges status of ‘terbinafine‐resistant’ <em>Trichophyton indotineae</em> as distinct species
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Host-driven subspeciation in hedgehog fungus, Trichophyton erinacei, an emerging cause of human dermatophytosis
<p><span class="fontstyle0"><em>Trichophyton</em> <em>erinacei</em> </span><span class="fontstyle2">is a main cause of dermatophytosis in hedgehogs and is increasingly reported from human infections worldwide. This pathogen was originally described in the European hedgehog (</span><em><span class="fontstyle0">Erinaceus europaeus</span></em><span class="fontstyle2">) but is also frequently found in the African four-toed hedgehog (</span><em><span class="fontstyle0">Atelerix albiventris</span></em><span class="fontstyle2">), a popular pet animal worldwide. Little is known about the taxonomy and population genetics of this pathogen despite its increasing importance in clinical practice. Notably, whether there are different populations or even cryptic species associated with different hosts or geographic regions is not known. To answer these questions, we collected 161 isolates, performed phylogenetic and population-genetic analyses, determined mating-type, and characterised morphology and physiology. Multigene phylogeny and microsatellite analysis supported </span><span class="fontstyle0"><em>T</em>. <em>erinacei</em> </span><span class="fontstyle2">as a monophyletic species, in contrast to highly incongruent single-gene phylogenies. Two main subpopulations, one specific mainly to </span><span class="fontstyle0"><em>Atelerix</em> </span><span class="fontstyle2">and second to </span><span class="fontstyle0"><em>Erinaceus</em> </span><span class="fontstyle2">hosts, were identified inside </span><span class="fontstyle0">T. <em>erinacei</em></span><span class="fontstyle2">, and slight differences in the size of microconidia and antifungal susceptibilities were observed among them. Although the process of speciation into two lineages is ongoing in </span><em><span class="fontstyle0">T. erinacei</span></em><span class="fontstyle2"><em>,</em> there is still gene flow between these populations. Thus, we present </span><span class="fontstyle0"><em>T</em>. <em>erinacei</em> </span><span class="fontstyle2">as a single species, with notable intraspecies variability in genotype and phenotype. The data from wild hedgehogs indicated that sexual reproduction in </span><span class="fontstyle0"><em>T</em>. <em>erinacei</em> </span><span class="fontstyle2">and de novo infection of hedgehogs from soil are probably rare events and that clonal horizontal spread strongly dominates. The molecular typing approach used in this study represents a suitable tool for further epidemiological surveillance of this emerging pathogen in both animals and humans. The results of this study also highlighted the need to use a multigene phylogeny ideally in combination with other independent molecular markers to understand the species boundaries of dermatophytes.</span></p>
Host-driven subspeciation in hedgehog fungus, Trichophyton erinacei, an emerging cause of human dermatophytosis
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qualABEER2 FOR Investigating Trichophyton violaceum Metabolites and their Effects In Vivo
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Gene expression profile of Trichophyton rubrum growth on protein substrates
GEO Series GSE69305. Trichophyton rubrum. 6 samples. Type: Expression profiling by array.
The transcriptional profile of Trichophyton rubrum co-cultured with human keratinocytes shows new insights about gene modulation by terbinafine.
GEO Series GSE135095. Trichophyton rubrum; Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Dual RNA-Seq Analysis of Trichophyton rubrum and HaCat Keratinocyte Co-Culture Highlights Important Genes for Fungal-Host Interaction
GEO Series GSE110073. Trichophyton rubrum; Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Trichophyton rubrum transcriptome in response to acriflavine
GEO Series GSE40425. Trichophyton rubrum. 4 samples. Type: Expression profiling by high throughput sequencing.
Cellular and molecular aspects of the interaction of Trichophyton rubrum in the human macrophage cell line THP-1 that simulates a deep infection
GEO Series GSE149222. Trichophyton rubrum; Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Huangqin Decoction Exerts Antifungal Effects by Interfering with Energy Metabolism of Trichophyton rubrum with Glyoxylate Cycle as a Potential Target
GEO Series GSE300994. Trichophyton rubrum. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome of Trichophyton rubrum grown on protein substrates and exposed to trans-chalcone
GEO Series GSE123979. Trichophyton rubrum. 15 samples. Type: Expression profiling by array.
Transcriptome Sequencing and Gene Expression Analysis of Trichophyton mentagrophytes under Different Culture Conditions
GEO Series GSE80604. Trichophyton mentagrophytes. 9 samples. Type: Expression profiling by high throughput sequencing.
Global Analysis of the dermatophyte Trichophyton rubrum when shifted from glucose to keratin
GEO Series GSE134406. Trichophyton rubrum. 18 samples. Type: Expression profiling by high throughput sequencing.
Challenges posed to the dermatophyte Trichophyton rubrum by sertraline; a drug predominantly used to treat human depression
GEO Series GSE218521. Trichophyton rubrum. 12 samples. Type: Expression profiling by high throughput sequencing.
Antifungal activity and potential inhibitory mechanism of Huangqin decoction on Trichophyton mentagrophytes
GEO Series GSE287990. Trichophyton mentagrophytes. 6 samples. Type: Expression profiling by high throughput sequencing.
A transcriptome survey of Trichophyton rubrum exposed to undecanoic acid
GEO Series GSE102872. Trichophyton rubrum. 9 samples. Type: Expression profiling by high throughput sequencing.
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