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33 results for “Trypanosomiasis”
Fig. 7. Box plots comparing average counts per 10 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 7. Box plots comparing average counts per 10 HPF of granulocytes, mononuclear cells, and thrombocytes between positive (n = 20) and negative (n = 20) 45- day-old Alpine swift nestlings sampled in 2022.
Fig. 5 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 5. Skeletal musculature of a nestling Alpine swift showing infiltrations of mononuclear inflammatory cells (A, B) and presumably extracellular, amastigote-like structures (C). Bursa fabricii of a nestling Alpine swift with depletion of the medullary follicle with lymphocytolysis (asterisk) and a distinct epithelium (arrows) (D).
Fig. 6 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 6. Blood smears of nestling Alpine swifts with high (A) and moderate (B) trypomastigote burdens. Close-up of a trypomastigote between erythrocytes (C).
Fig. 4 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 4. Distribution of louse flies on an Alpine swift nestling (A) compared with the distribution of bruising on post-mortem examination with plumage removed (B).
Fig. 3 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 3. Missing (left wing) and poor quality (right wing) primary feathers on a 45-day-old nestling.
Fig. 1 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 1. Map of Switzerland with the locations and appearance of the three evaluated colonies (A, B, C).
Fig. 2 in Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?
Fig. 2. Fledging indexes of 7 Swiss Alpine swift colonies from 2015 to 2022.
Efficacy and Safety of Acoziborole (SCYX-7158) in Patients With Human African Trypanosomiasis Due to T.b. Gambiense
ClinicalTrials.gov study NCT03087955. IPD Sharing: YES. Countries: 2. Publications: 1.
Fexinidazole in Human African Trypanosomiasis Due to T. b. Rhodesiense
ClinicalTrials.gov study NCT03974178. IPD Sharing: NO. Countries: 2. Publications: 1.
Fexinidazole in Human African Trypanosomiasis Due to T.b. Gambiense at Any Stage
ClinicalTrials.gov study NCT03025789. IPD Sharing: NO. Countries: 2. Publications: 1.
Data from: Genetic diversity and population structure of Glossina morsitans morsitans in the active foci of human African trypanosomiasis in Zambia and Malawi
The tsetse fly, Glossina morsitans morsitans, is a significant problem in Zambia and Malawi. It is the vector for the human infective parasite Trypanosoma brucei rhodesiense, which causes human African trypanosomiasis, and various Trypanosoma species, which cause African animal trypanosomiasis. Understanding the genetic diversity and population structure of G. m. morsitans is the basis of elucidating the connectivity of the tsetse fly populations, information that is essential in implementing successful tsetse fly control activities. This study conducted a population genetic study using partial mitochondrial cytochrome oxidase gene 1 (CO1) and 10 microsatellite loci to investigate the genetic diversity and population structure of G. m. morsitans captured in the major HAT foci in Zambia and Malawi. We have included 108 and 99 G. m. morsitans samples for CO1 and microsatellite analyses respectively. Our results suggest the presence of two different genetic clusters of G. m. morsitans, existing East and West of the escarpment of the Great Rift Valley. We have also revealed genetic similarity between the G. m. morsitans in Kasungu National Park and those in the Luangwa river basin in Zambia, indicating that this population should also be included in this historical tsetse belt. Although further investigation is necessary to illustrate the whole picture in East and Southern Africa, this study has extended our knowledge of the population structure of G. m. morsitans in Southern Africa.
Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158
ClinicalTrials.gov study NCT01533961. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine (NECT) for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis (HAT) in
ClinicalTrials.gov study NCT00906880. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2
ClinicalTrials.gov study NCT01685827. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: Early Test-of-cure
ClinicalTrials.gov study NCT03112655. IPD Sharing: NO. Countries: 1. Publications: 6.
Efficacy and Safety of Fexinidazole in Children at Least 6 Years Old and Weighing Over 20 kg With Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open Study, plu
ClinicalTrials.gov study NCT02184689. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Trial of DB289 for the Treatment of Stage I African Trypanosomiasis
ClinicalTrials.gov study NCT00803933. IPD Sharing: Not stated. Countries: 1. Publications: 1.
CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY)
ClinicalTrials.gov study NCT02369978. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis
ClinicalTrials.gov study NCT00330148. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Trial of DB289 for the Treatment of Stage I African Trypanosomiasis
ClinicalTrials.gov study NCT00802594. IPD Sharing: Not stated. Countries: 2. Publications: 1.
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