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425 results for “Type 1 diabetes mellitus”
Supplemental data for: Mapping lifestyle factors in blood glucose variability in adolescents with Type 1 Diabetes Mellitus- A pilot study
<div> <p>The dataset was used in the paper “Mapping lifestyle factors in blood glucose variability in adolescents with Type 1 Diabetes Mellitus- A pilot study”. The article is currently under review for publication. DOI to be inserted.</p> </div> <div> <p>A data-in-brief article is to be published to give in-depth information about the data collected to improve reproducibility "Dataset for: Lifestyle Factors and Blood Glucose Variability in Adolescents with Type 1 Diabetes Mellitus". DOI to be inserted. </p> <p> </p> <p>The aim of the study was to assess whether adolescents with T1D in Ireland meet current nutrition and physical activity (PA) guidelines and to explore the impact of nutrition and PA on glycaemic variability (GV). The dataset includes continuous glucose monitoring (CGM) data, dietary intake records, and PA metrics, providing a comprehensive view of the participants' glucose levels and associated lifestyle behaviours.</p> </div>
Structural Homology of Epitope Pair Candidates for Molecular Mimicry Trigger of Type 1 Diabetes Mellitus
<p><strong><em><span>Background:</span></em></strong><span> </span><span>Molecular mimicry, where foreign and self-peptides contain similar epitopes, can induce autoimmune responses. Identifying potential molecular mimics and studying their properties is key to understanding the onset of autoimmune diseases such as type 1 diabetes mellitus (T1DM). Previous work identified pairs of infectious epitopes (E<sub>INF</sub>) and T1DM epitopes (E<sub>T1D</sub>) that demonstrated sequence homology; however, structural homology was not considered. Correlating sequence homology with structural properties is important for streamlining translational investigation of potential molecular mimics. Therefore, the purpose of this work is to compare sequence homology with structural homology by calculating the structures and electrostatic potential surfaces of the epitope pairs identified in previous work from our laboratory. </span></p> <p><strong><span> </span></strong><strong><em><span>Results:</span></em></strong><span> </span><span> For each epitope pair the root mean square deviation (RMSD) was calculated between their predicted structures and their electrostatic potentials were compared. Structures were predicted using the AlphaFold software program. </span><span>Of the 52 epitope pairs considered here only 10 do not exhibit any matching (i.e. less than 3 residues overlap). When considering all residues the RMSD ranges from 0.33 Å to 11.66 Å with an average of 2.68 Å. Twenty-two pairs (42%) have RMSD of less than 1.5 Å and 30 (58%) less than 3 Å. Even some of the matching pairs show some electrostatic similarities that need to be considered. In general there is good agreement between the folding predicted for the isolated </span><span>E<sub>INF</sub></span><span> and E<sub>T1D</sub> epitopes and the folding of the corresponding amino acid sequence in the parent antigen, but in some cases there are deviation that need to be considered, even when the RMDS is small.</span></p> <p><span> </span><strong><em><span>Conclusions:</span></em></strong><span> </span><span>Despite differences, most of the E<sub>INF</sub><span>/</span>E<sub>T1D </sub>pairs selected by sequence homology show similar structural and electrostatic distributions, indicating that the E<sub>INF</sub> may bind to the same protein targets, the major histocompatibility complex molecules, for T1DM, leading to molecular mimicry onset of the disease. These findings suggest that searching for epitope pairs using sequence homology, a much less computationally demanding approach, leads to strong candidates for molecular mimicry that should be considered for further study. Still structure and full docking calculations will be necessary to advance the in-silico molecular mimicry predictions. </span> Here we presnt the following files:</p> <p><span><span>·<span> </span></span></span>Fasta files of all epitopes studied.</p> <p><span><span>·<span> </span></span></span>Alphafold calculated Structures of all epitopes.</p> <p><span><span>·<span> </span></span></span>Antigen structures.</p> <p><span><span>·<span> </span></span></span>Epitope pair structure comparison and their electrostatics.</p> <p> </p> <p> </p>
Comparison of the Safety and Efficacy of HOE901-U300 With Lantus in Children and Adolescents With Type 1 Diabetes Mellitus
ClinicalTrials.gov study NCT02735044. IPD Sharing: YES. Countries: 24. Publications: 1.
Comparison of SAR341402 to NovoLog in Adult Patients With Type 1 Diabetes Mellitus Also Using Insulin Glargine
ClinicalTrials.gov study NCT03874715. IPD Sharing: YES. Countries: 1. Publications: 2.
Epidemiological profile and diabetes control of Type 1 Diabetes Mellitus patients in Karbala Governorate, Iraq
<p><strong>Epidemiological profile and diabetes control of Type 1 Diabetes Mellitus patients in Karbala Governorate, Iraq</strong></p>
Adherence to Guidelines VAccination in Type 1 DIabetes Mellitus Patients (AVADI-1).
ClinicalTrials.gov study NCT03478254. IPD Sharing: YES. Countries: 1. Publications: 6.
Phase II Pharmacokinetics Study of Humalog and Humulin-R With and Without rHuPH20 in Type 1 Diabetes Mellitus
ClinicalTrials.gov study NCT00774800. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus
ClinicalTrials.gov study NCT00419562. IPD Sharing: YES. Countries: 6. Publications: 7.
Efficacy and Safety of Sotagliflozin in Young Adult Patients With Type 1 Diabetes Mellitus and Elevated Hemoglobin A1C
ClinicalTrials.gov study NCT02383940. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Albiglutide Versus Placebo in Insulin-treated Subjects With New-onset Type 1 Diabetes Mellitus
ClinicalTrials.gov study NCT02284009. IPD Sharing: YES. Countries: 5. Publications: 1.
A Clinical Proof-of-principle Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function
ClinicalTrials.gov study NCT02443155. IPD Sharing: Not stated. Countries: 18. Publications: 1.
A Study to Investigate the Efficacy and Safety of RG7774 in Patients With Diabetes Mellitus Type 1 or Type 2 With Treatment-Naive Diabetic Retinopathy
ClinicalTrials.gov study NCT04265261. IPD Sharing: YES. Countries: 7. Publications: 1.
Web-Based Simulation Tool For Self-Management Support In Type 1 Diabetes Mellitus
ClinicalTrials.gov study NCT04439903. IPD Sharing: NO. Countries: 1. Publications: 2.
Trial of Otelixizumab for Adolescents and Adults With Newly Diagnosed Type 1 Diabetes Mellitus (Autoimmune): DEFEND-2
ClinicalTrials.gov study NCT01123083. IPD Sharing: YES. Countries: 1. Publications: 3.
Association of Systemic Immune-inflammation Index and Severity of Diabetic Ketoacidosis in Type 1 Diabetes Mellitus
ClinicalTrials.gov study NCT06251895. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Investigation of Otelixizumab in New-Onset, Autoimmune Type 1 Diabetes Mellitus Patients
ClinicalTrials.gov study NCT02000817. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study of Effects of Canagliflozin as Add-on Therapy to Insulin in the Treatment of Participants With Type 1 Diabetes Mellitus (T1DM)
ClinicalTrials.gov study NCT02139943. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Development of a Behavioral Observer for Type 1 Diabetes Mellitus
ClinicalTrials.gov study NCT01434030. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Infusion Site Pain After Infusion of Excipients in Participants With Type 1 Diabetes Mellitus
ClinicalTrials.gov study NCT05067270. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Trial Evaluating Technosphere® Insulin Versus Insulin Aspart in Subjects With Type 1 Diabetes Mellitus Over a 24-week Treatment Period
ClinicalTrials.gov study NCT01445951. IPD Sharing: Not stated. Countries: 4. Publications: 2.
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OpenNeuro
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