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47 results for “Type 1 interferon”
Data from: Type 1 interferon-inducible gene expression in QuantiFERON Gold TB-positive uveitis: a tool to stratify a high versus low risk of active tuberculosis?
QuantiFERON-Gold TB (QFT)-positive patients with undetermined cause of uveitis are problematic in terms of whether to diagnose and treat them for tuberculosis (TB). Here, we investigated whether peripheral blood expression of type 1 interferon (IFN)-inducible genes may be of use to stratify QFT-positive patients with uveitis into groups of high versus low risk of having active TB-associated uveitis. We recruited all new uveitis patients in Cipto Mangunkusumo Hospital, Jakarta, Indonesia for one year. We included 12 patients with uveitis and clinically diagnosed active pulmonary TB, 58 QFT-positive patients with uveitis of unknown cause, 10 newly diagnosed sputum-positive active pulmonary TB patients without uveitis and 23 QFT-negative healthy controls. Expression of 35 type 1 IFN-inducible genes was measured in peripheral blood cells from active pulmonary TB patients without uveitis and healthy controls. Differentially expressed genes were identified and used for further clustering analyses of the uveitis groups. A type-1 IFN gene signature score was calculated and the optimal cut-off value for this score to differentiate active pulmonary TB from healthy controls was determined and applied to QFT-positive patients with uveitis of unknown cause. Ten type 1 IFN-inducible genes were differentially expressed between active pulmonary TB and healthy controls. Expression of these 10 genes in QFT-positive patients with uveitis of unknown cause revealed three groups: 1); patients resembling active pulmonary TB, 2); patients resembling healthy controls, and 3); patients displaying an in-between gene expression pattern. A type 1 IFN gene signature score ≥5.61 displayed high sensitivity (100%) and specificity (91%) for identification of active TB. Application of this score to QFT-positive patients with uveitis of unknown cause yielded two groups with expected different likelihood (high vs. low) of having active-TB uveitis, and therefore may be useful in clinical management decisions.
Interferon-Alpha for Diabetes Mellitus Type 1
ClinicalTrials.gov study NCT00024518. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Type 1 Interferon Induced Changes to Exercise Adaptations in Systemic Lupus Erythematosus Patients
ClinicalTrials.gov study NCT05478018. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: Type 1 interferon-inducible gene expression in QuantiFERON Gold TB-positive uveitis: a tool to stratify a high versus low risk of active tuberculosis?
Open the record for dataset details and reuse information.
Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon [RNA-Seq_1]
GEO Series GSE178447. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Male sex and age biases viral burden, viral shedding, and type 1 and 2 interferon responses during SARS-CoV-2 infection in ferrets
GEO Series GSE160824. Mustela putorius furo. 79 samples. Type: Expression profiling by high throughput sequencing.
TPL-2;ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I interferon production [Set 1]
GEO Series GSE47672. Mus musculus. 26 samples. Type: Expression profiling by array.
Type 1 interferon and pattern recognition receptor signaling following particulate matter inhalation
GEO Series GSE34056. Mus musculus. 47 samples. Type: Expression profiling by array.
Host derivation of Sindbis virus influences mammalian type 1 interferon response to infection
GEO Series GSE234344. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor
GEO Series GSE147626. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Distinct immune responses to type I and III interferons are regulated by interferon regulatory factor 1
GEO Series GSE115198. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Type 1 interferon signaling is crucial from the loss of tolerance nd the development of autoreactive B cells.
GEO Series GSE115349. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA [1]
GEO Series GSE274069. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Epidermal Growth Factor Receptor inhibition triggers Type 1 Interferon signature in human keratinocytes
GEO Series GSE74407. Homo sapiens. 9 samples. Type: Expression profiling by array.
High throughput characterization of human glioblastoma multiforme cell response to Type 1 interferons
GEO Series GSE163949. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Myxoma virus subdues type 1 interferon responses through a host range determinant
GEO Series GSE196608. Homo sapiens; Myxoma virus. 12 samples. Type: Expression profiling by high throughput sequencing.
PPARg Deficiency Suppresses the Release of IL-1b and a in Macrophages via a Type 1 Interferon Dependent Mechanism
GEO Series GSE117115. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Trained immunity of alveolar macrophages depends on metabolic rewiring and type 1 interferon signaling (RNA-Seq)
GEO Series GSE184683. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Interleukin-1- and Type I Interferon-Dependent Enhanced Immunogenicity of an NYVAC-HIV-1 Env-Gag-Pol-Nef Vaccine Vector with Dual Deletions of Type I and Type II Interferon-Binding Proteins
GEO Series GSE65412. Homo sapiens. 20 samples. Type: Expression profiling by array.
The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1
GEO Series GSE225460. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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