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23 results for “Uropathogenic Escherichia coli”
Dataset - Dynamic persistence of intracellular bacterial communities of uropathogenic Escherichia coli in a human bladder-chip model of urinary tract infections
<p>Dataset for manuscript posted at biorxiv: https://doi.org/10.1101/2021.01.03.42483 and in revision for eLife. Data corresponding to each main figure and its associated figure supplements are in seperate .zip folders.</p>
Characterization of virulence factors and antibiotic resistance pattern of uropathogenic Escherichia coli strains in a tertiary care center
<p><strong>Background</strong>: Urinary tract infections (UTIs) are the most prevalent bacterial infection in humans. The uropathogenic E. <em>coli </em>(UPEC) express a wide range of virulence factors that contribute to their pathogenicity<span>.</span><span> The emergence of Multidrug resistance(MDR)-associated UTI is increasing off late</span>. Hence this study was undertaken to monitor the distribution of virulence factors among UPEC strains and to note the antibiogram, outcome and type of associated UTI.</p> <p><strong>Methods</strong>: A prospective cross-sectional time-bound study of 6 months was done on clinically significant <span>urinary </span>isolates of <em>Escherichia</em> <em>coli</em>. <span>Detection of haemolysin production and serum resistance</span><span> was done by </span><span>phenotypic methods. Genotypic characterization of the virulence genes (papC, iutA, hlyA, cnf1) was done by multiplex PCR. </span>Demographic data, clinical history, antibiogram and type of UTI were collected from clinical case records.</p> <p><strong>Results</strong>: 75 <em>E</em>. <em>coli</em> isolates from patients with suspected urinary tract infections were included. <span>Females had a higher preponderance of UTI (66.7%).93% of the patients were adults and the remaining 7% were from the paediatric population. 24 (32%) isolates showed haemolysis by plate haemolysis method, and all 75 (100%) isolates were serum resistant. </span>Out of 75 isolates, 65 were positive for at least one of the four targeted genes, while the remaining 10 isolates were negative for all 4 genes. <span>Multidrug resistance was found in 40 (53.3%) isolates. 97.4% of the UTI cases had a favourable clinical outcome at discharge. Mortality due to urosepsis was 2.6%.</span></p> <p><strong>Conclusion</strong>:<span> The association of hemolysin production with resistance to imipenem and norfloxacin in UPEC strains was significant. T</span><span>he presence of the hlyA gene is positively associated with ceftazidime resistance. </span><span>Nitrofurantoin, piperacillin tazobactam and cefaperazone sulbactam maybe suitable candidates for empirical therapy of UTIs. Drugs like aminoglycosides, carbapenems and fosfomycin may be used as reserve drugs in the treatment of MDR-UTI</span><span>. However, inappropriate usage can gradually increase antibiotic resistance. Hence, proper selection of antibiotics in hospitals taking into account the local antibiogram is needed to reduce the emergence of antibiotic resistance.</span></p>
Characterization of virulence factors and antibiotic resistance pattern of uropathogenic Escherichia coli strains in a tertiary care center
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Genetically diverse uropathogenic Escherichia coli adopt a common transcriptional program in patients with urinary tract infections
GEO Series GSE128997. Escherichia coli. 28 samples. Type: Expression profiling by high throughput sequencing.
The RyfA small RNA serves as a master regulator of stress responses and virulence in uropathogenic Escherichia coli
GEO Series GSE157450. Escherichia coli. 6 samples. Type: Expression profiling by high throughput sequencing.
Gardnerella exposures alter bladder gene expression and augment uropathogenic Escherichia coli urinary tract infection in mice.
GEO Series GSE203195. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Ferric Citrate Uptake is a Virulence Factor in Uropathogenic Escherichia coli
GEO Series GSE188170. Escherichia coli. 6 samples. Type: Expression profiling by high throughput sequencing.
Comprehensive analysis of PNA-based antisense antibiotics targeting various essential genes in uropathogenic Escherichia coli
GEO Series GSE191313. Escherichia coli 536. 41 samples. Type: Expression profiling by high throughput sequencing.
Detection of Biofilm Among Uropathogenic Escherichia Coli Clinical Isolates in Suez Canal University Hospitals
ClinicalTrials.gov study NCT06252428. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Transcriptional alterations of virulence-associated genes in extended spectrum beta-lactamase (ESBL)-producing uropathogenic Escherichia coli during morphologic transitions induced by ineffective anti
GEO Series GSE99661. Escherichia coli O157:H7 str. Sakai; Escherichia coli CFT073; Escherichia coli str. K-12 substr. MG1655; Escherichia coli; Escherichia coli O157:H7 str. EDL933. 16 samples. Type: Expression profiling by array.
Human renal fibroblasts are strong immunomobilizers during a urinary tract infection mediated by uropathogenic Escherichia coli
GEO Series GSE124917. Homo sapiens. 6 samples. Type: Expression profiling by array.
Nitrosative stress response in uropathogenic Escherichia coli (UPEC)
GEO Series GSE69830. Escherichia coli CFT073. 6 samples. Type: Expression profiling by high throughput sequencing.
Comparison of gene expression profiles of uropathogenic Escherichia coli CFT073 after prolonged exposure to subinhibitory concentrations of different biocides
GEO Series GSE135556. Escherichia coli CFT073; Escherichia coli. 15 samples. Type: Expression profiling by array.
TosR-mediated regulation of adhesins and biofilm formation in uropathogenic Escherichia coli
GEO Series GSE112878. Escherichia coli. 6 samples. Type: Expression profiling by high throughput sequencing.
Testing the impact of Type I Restriction Modification Systems on Gene Expression in Uropathogenic Escherichia coli
GEO Series GSE165421. Escherichia coli CFT073; Escherichia coli str. K-12 substr. MG1655; Escherichia coli UTI89. 64 samples. Type: Expression profiling by high throughput sequencing.
Cranberry derived proanthocyanidins induce a state of iron-limitation in uropathogenic Escherichia coli CFT073 as revealed by microarray analysis
GEO Series GSE25745. Escherichia coli. 6 samples. Type: Expression profiling by array.
Conditioning of uropathogenic Escherichia coli to nitrosative stress
GEO Series GSE15319. Escherichia coli; Escherichia coli UTI89. 4 samples. Type: Expression profiling by array.
YciR, a specific 3′-phosphodiesterases, plays a role in the pathogenesis of Uropathogenic Escherichia coli CFT073
GEO Series GSE189294. Escherichia coli CFT073. 2 samples. Type: Expression profiling by high throughput sequencing.
Cell wall-deficient Mycoplasma hominis represses biofilm formation of uropathogenic Escherichia coli.
GEO Series GSE43376. Escherichia coli CFT073. 1 samples. Type: Expression profiling by array.
MicroRNAs regulate differential innate immune response to uropathogenic and commensal-like Escherichia coli infection in the surrogate insect model Galleria mellonella
GEO Series GSE123965. Galleria mellonella. 3 samples. Type: Non-coding RNA profiling by high throughput sequencing.
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