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85 results for “VHL”
The raw data of the genome-wide CRISPR screens for VHL-WT and VHL-L188V Kelly cells
<p>The raw data including the conditions, reference, and PoolQ output files of the genome-wide CRISPR screens for VHL-WT and VHL-L188V Kelly cells were published in the paper "Total loss of VHL gene function impairs neuroendocrine cancer cell fitness due to excessive HIF2α activity".</p>
Evaluation of Sunitinib Malate in Patients With Von Hippel-Lindau Syndrome (VHL) Who Have VHL Lesions to Follow
ClinicalTrials.gov study NCT00330564. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vaccine Therapy With Tumor Specific Mutated VHL Peptides in Adult Cancer Patients With Renal Cell Carcinoma
ClinicalTrials.gov study NCT00001703. IPD Sharing: Not stated. Countries: 1. Publications: 3.
TKI 258 in Von Hippel-Lindau Syndrome (VHL)
ClinicalTrials.gov study NCT01266070. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)
ClinicalTrials.gov study NCT03401788. IPD Sharing: YES. Countries: 4. Publications: 3.
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointest
ClinicalTrials.gov study NCT04924075. IPD Sharing: YES. Countries: 22. Publications: 1.
Real-World Effectiveness and Pharmacogenetics of Belzutifan in VHL Syndrome: The BELIEVE-VHL Trial
ClinicalTrials.gov study NCT07167329. IPD Sharing: YES. Countries: 1. Publications: 16.
Data from: Computational and experimental characterization of dVHL establish a Drosophila model of VHL syndrome
The von Hippel-Lindau (VHL) cancer syndrome is associated with mutations in the VHL gene. The pVHL protein is involved in response to changes in oxygen availability as part of an E3-ligase that targets the Hypoxia-Inducible Factor for degradation. pVHL has a molten globule configuration with marginal thermodynamic stability. The cancer-associated mutations further destabilize it. The Drosophila homolog, dVHL, has relatively low sequence similarity to pVHL, and is also involved in regulating HIF1-α. Using in silico, in vitro and in vivo approaches we demonstrate high similarity between the structure and function of dVHL and pVHL. These proteins have a similar fold, secondary and tertiary structures, as well as thermodynamic stability. Key functional residues in dVHL are evolutionary conserved. This structural homology underlies functional similarity of both proteins, evident by their ability to bind their reciprocal partner proteins, and by the observation that transgenic pVHL can fully maintain normal dVHL-HIF1-α downstream pathways in flies. This novel transgenic Drosophila model is thus useful for studying the VHL syndrome, and for testing drug candidates to treat it.
Data from: Computational and experimental characterization of dVHL establish a Drosophila model of VHL syndrome
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B cells sorted from VHL floxed MB1- Cre
GEO Series GSE129513. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Effect of depletion of vhl-1 on gene expression in young adult C. elegans
GEO Series GSE224016. Caenorhabditis elegans. 6 samples. Type: Expression profiling by high throughput sequencing.
Towards a CRISPR-Based Mouse Model of Vhl-deficient Clear Cell Kidney Cancer: Initial Experience and Lessons Learned
GEO Series GSE275231. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
H3K9me3 and H3K27me3 ChIP-seq in wild-type, Mfn2-/-, Vhl-/- and HIF1dPA regenerating myofibers.
GEO Series GSE185103. Mus musculus. 25 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Microarray characterization of Vhl; Vhl, Hif1a; Vhl, Hif2a and Vhl, Hif1a, Hif2a deficient primary kidney cells
GEO Series GSE75745. Mus musculus. 13 samples. Type: Expression profiling by array.
RNA-seq of CD4 T cells from the lungs of M. tuberculosis infected WT and vhl fl/fl cd4 cre mice
GEO Series GSE190909. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Next Generation Sequencing of 786-O-Ctrl and786-O-VHL Transcriptomes
GEO Series GSE186013. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Gene expression differences between wild-type and Vhl mutant mice in kidney stones process
GEO Series GSE209996. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
VHL restoration alters cis-regulatory landscape
GEO Series GSE102095. Homo sapiens. 52 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Functional TRIM24 degraders via conjugation of ineffectual bromodomain and VHL ligands [RNA-seq]
GEO Series GSE100572. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Transcription factors enriched in tumor-associated enhancers in VHL-deficient ccRCC
GEO Series GSE86092. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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