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107 results for “Vascular tissue”
Histological Dataset for Microvascular Segmentation of Tissue-Engineered Vascular Grafts
<p><strong>Objectives: </strong>The pursuit of understanding vascular tissue regeneration within tissue-engineered vascular grafts (TEVGs) is of paramount importance due to the critical role these grafts play in replacing damaged or diseased blood vessels. TEVGs offer a promising alternative to traditional grafts, with the potential to integrate into the host's tissue and support the natural regenerative processes. However, challenges such as thrombosis, inflammation, and the need for grafts that can adapt to the dynamic biological environment remain. By studying the regenerative processes in TEVGs, researchers can gain insights into the mechanisms that underpin successful graft integration and function, which is essential for improving patient outcomes in vascular surgeries. This dataset, with its detailed annotations of histological features, provides a valuable resource for developing and refining machine-learning models that can analyze and predict patterns of vascular tissue regeneration. The ability to accurately segment and quantify microvessels and immune cells in regenerated arteries is a significant step forward in distinguishing between physiological and pathological regeneration, ultimately contributing to the design of more effective and reliable TEVGs for clinical use.</p> <p><strong>Ethical Approval: </strong>Experimental strategy of the study is described in detail in <a href="https://www.mdpi.com/2073-4360/14/23/5149" target="_blank" rel="noopener">[1]</a> and <a href="https://www.mdpi.com/1422-0067/24/10/8540" target="_blank" rel="noopener">[2]</a>. The study was conducted according to the guidelines of the Declaration of Helsinki, and was approved by the Local Ethical Committee of the Research Institute for Complex Issues of Cardiovascular Diseases (Kemerovo, Russia, protocol code 2020/06, date of approval: 19 February 2020). Animal experiments were performed in accordance with the European Convention for the Protection of Vertebrate Animals (Strasbourg, 1986) and Directive 2010/63/EU of the European Parliament on the protection of animals used for scientific purposes. For the implantation, we used female Edilbay sheep of 42–45 kg body weight which were received from the Animal Core Facility of the Research Institute for Complex Issues of Cardiovascular Diseases (Kemerovo, Russia) and selected for the surgery by Doppler ultrasonography to identify those having carotid artery diameter of 4.0 ± 0.2 mm.</p> <p><strong>Description: </strong>The dataset comprises a collection of Whole Slide Images (WSIs) obtained from biodegradable TEVGs implanted into the carotid arteries of 20 sheep. A total of 104 WSIs were acquired, each measuring an average size of 135,000 x 123,000 pixels. These WSIs were stained using Hematoxylin and Eosin (H&E), a common practice for highlighting the structure of tissue sections, which facilitates the detailed examination of histological features. These WSIs were automatically sliced into 99,831 patches of 3,000 x 3,000 pixels and subsequently filtered, resulting in 1,401 selected patches for manual annotation.</p> <p><strong>Annotation Method:</strong> Two pathologists independently selected and meticulously annotated the 1401 patches, identifying nine distinct histological features associated with vascular tissue regeneration. These features include <em>arteriole lumen (AL)</em>, <em>arteriole media (AM)</em>, <em>arteriole adventitia (AA)</em>, <em>venule lumen (VL)</em>, <em>venule wall (VW)</em>, <em>capillary lumen (CL)</em>, <em>capillary wall (CW)</em>, <em>immune cells (IC)</em>, and <em>nerve trunks (NT)</em>. The annotations were performed using binary masks, delineating each feature within the patches. Subsequently, a senior pathologist conducted a triple verification process, reviewing and refining the annotations to ensure accuracy and consistency. The annotations are provided in the form of binary masks, meticulously defined for each feature within the patches.</p> <p><strong>Dataset Split:</strong> Given the limited number of subjects studied, comprising 20 sheep, we employed a 5-fold cross-validation technique to split our dataset. This method was chosen because it allows for the efficient use of limited data, ensuring that each observation has the opportunity to be used in both the training and testing sets, thus reducing bias and providing a more accurate estimate of the model's performance. In this approach, each fold involved 16 sheep for training and the remaining 4 for testing (see <em>Table 1</em> and <em>Figure 3</em>). This partitioning scheme was consistently applied to maintain the integrity of subject groups within each subset and to prevent data leakage. The 5-fold cross-validation is particularly beneficial for our study's objectives as it maximizes the training data available for developing robust machine learning models while also ensuring that the models are tested on unseen data, thereby enhancing the generalizability of our findings.</p> <p><strong>Access to the Study:</strong> Further information about this study, including curated source code, dataset details, and trained models, can be accessed through the following repositories:</p> <ul> <li><strong>Source code:</strong> <a href="https://github.com/ViacheslavDanilov/histology_segmentation" target="_blank" rel="noopener">https://github.com/ViacheslavDanilov/histology_segmentation</a></li> <li><strong>Dataset:</strong> <a href="https://doi.org/10.5281/zenodo.10838384" target="_blank" rel="noopener">https://doi.org/10.5281/zenodo.10838384</a></li> <li><strong>Models:</strong> <a href="https://doi.org/10.5281/zenodo.10838431" target="_blank" rel="noopener">https://doi.org/10.5281/zenodo.10838431</a></li> </ul> <div> </div> <div><em><strong>Table 1.</strong> Patch and feature distributions across folds and subsets</em> <table> <tbody> <tr> <td> <p><strong>Fold</strong></p> </td> <td> <p><strong>Subset</strong></p> </td> <td> <p><strong>Patches</strong></p> </td> <td> <p><strong>AL</strong></p> </td> <td> <p><strong>AM</strong></p> </td> <td> <p><strong>AA</strong></p> </td> <td> <p><strong>VL</strong></p> </td> <td> <p><strong>VW</strong></p> </td> <td> <p><strong>CL</strong></p> </td> <td> <p><strong>CW</strong></p> </td> <td> <p><strong>IC</strong></p> </td> <td> <p><strong>NT</strong></p> </td> <td> <p><strong>Total </strong></p> </td> </tr> <tr> <td> <p>1</p> </td> <td> <p>Train</p> </td> <td> <p>1168</p> </td> <td> <p>510</p> </td> <td> <p>512</p> </td> <td> <p>220</p> </td> <td> <p>675</p> </td> <td> <p>648</p> </td> <td> <p>770</p> </td> <td> <p>765</p> </td> <td> <p>409</p> </td> <td> <p>448</p> </td> <td> <p>4957</p> </td> </tr> <tr> <td>1</td> <td> <p>Test</p> </td> <td> <p>233</p> </td> <td> <p>81</p> </td> <td> <p>84</p> </td> <td> <p>36</p> </td> <td> <p>186</p> </td> <td> <p>169</p> </td> <td> <p>178</p> </td> <td> <p>182</p> </td> <td> <p>91</p> </td> <td> <p>25</p> </td> <td> <p>1032</p> </td> </tr> <tr> <td> <p>2</p> </td> <td> <p>Train</p> </td> <td> <p>1053</p> </td> <td> <p>406</p> </td> <td> <p>411</p> </td> <td> <p>179</p> </td> <td> <p>678</p> </td> <td> <p>638</p> </td> <td> <p>743</p> </td> <td> <p>746</p> </td> <td> <p>423</p> </td> <td> <p>315</p> </td> <td> <p>4539</p> </td> </tr> <tr> <td>2</td> <td> <p>Test</p> </td> <td> <p>348</p> </td> <td> <p>185</p> </td> <td> <p>185</p> </td> <td> <p>77</p> </td> <td> <p>183</p> </td> <td> <p>179</p> </td> <td> <p>205</p> </td> <td> <p>201</p> </td> <td> <p>77</p> </td> <td> <p>158</p> </td> <td> <p>1450</p> </td> </tr> <tr> <td> <p>3</p> </td> <td> <p>Train</p> </td> <td> <p>1127</p> </td> <td> <p>507</p> </td> <td> <p>511</p> </td> <td> <p>222</p> </td> <td> <p>743</p> </td> <td> <p>702</p> </td> <td> <p>759</p> </td> <td> <p>760</p> </td> <td> <p>299</p> </td> <td> <p>423</p> </td> <td> <p>4926</p> </td> </tr> <tr> <td>3</td> <td> <p>Test</p> </td> <td> <p>274</p> </td> <td> <p>84</p> </td> <td> <p>85</p> </td> <td> <p>34</p> </td> <td> <p>118</p> </td> <td> <p>115</p> </td> <td> <p>189</p> </td> <td> <p>187</p> </td> <td> <p>201</p> </td> <td> <p>50</p> </td> <td> <p>1063</p> </td> </tr> <tr> <td> <p>4</p> </td> <td> <p>Train</p> </td> <td> <p>1064</p> </td> <td> <p>466</p> </td> <td> <p>472</p> </td> <td> <p>199</p> </td> <td> <p>611</p> </td> <td> <p>566</p> </td> <td> <p>759</p> </td> <td> <p>758</p> </td> <td> <p>423</p> </td> <td> <p>291</p> </td> <td> <p>4545</p> </td> </tr> <tr> <td>4</td> <td> <p>Test</p> </td> <td> <p>337</p> </td> <td> <p>125</p> </td> <td> <p>124</p> </td> <td> <p>57</p> </td> <td> <p>250</p> </td> <td> <p>251</p> </td> <td> <p>189</p> </td> <td> <p>189</p> </td> <td> <p>77</p> </td> <td> <p>182</p> </td> <td> <p>1444</p> </td> </tr> <tr> <td> <p>5</p> </td> <td> <p>Train</p> </td> <td> <p>1192</p> </td> <td> <p>475</p> </td> <td> <p>478</p> </td> <td> <p>204</p> </td> <td> <p>737</p> </td> <td> <p>714</p> </td> <td> <p>761</p> </td> <td> <p>759</p> </td> <td> <p>446</p> </td> <td> <p>415</p> </td> <td> <p>4989</p> </td> </tr> <tr> <td>5</td> <td> <p>Test</p> </td> <td> <p>209</p> </td> <td> <p>116</p> </td> <td> <p>118</p> </td> <td> <p>52</p> </td> <td> <p>124</p> </td> <td> <p>103</p> </td> <td> <p>187</p> </td> <td> <p>188</p> </td> <td> <p>54</p> </td> <td> <p>58</p> </td> <td> <p>1000</p> </td> </tr> </tbody> </table> </div> <p> </p>
Research data supporting "Pericyte seeded dual peptide scaffold with improved endothelialization for vascular graft tissue engineering"
<p>Raw research data supporting the paper:</p> <p>Campagnolo, P. <em>et al</em>., Pericyte seeded dual peptide scaffold with improved endothelialization for vascular graft tissue engineering, 2016, Advanced Healthcare Materials, 5(23), 3046-3055.</p> <p> </p>
Text-fig. 14. Photomicrographs of thin sections of specimen BP/16/1732 Palmoxylon dutoitii from Mhengere Hill, Gorongosa, Mozambique. a: transverse section (TS) with four fibre vascular bundles (fvb) and poorly preserved parenchyma between; b: diagram of one of the fvbs in (a) of the reniform type (f – fibres, mx – metaxylum, p – phloem, px – protoxylum); c: close up of the vascular part of a fvb with 2 metaxylem elements and the collapsed cells to the lower left represents the phloem; d: fvb with 2 metaxylem elements, fibrous part to the left and parencymarous ground tissue to the right; e: lower magnification of fvb in (c); f: fvb with three metaxylem elements and phloem patch below; g: longitudinal section (LS) showing the vascular sections alternating with the fibrous sections; h: LS showing the horizontal thickening on the walls of the metaxylem vessels and a patch of parenchyma to the right (darker cells); i: spheroid echinate phytoliths that are typical of Hyphaene and Borassus. in Stratigraphy, Chronology And Palaeontology Of The Tertiary Rocks Of The Cheringoma Plateau, Mozambique
Text-fig. 14. Photomicrographs of thin sections of specimen BP/16/1732 Palmoxylon dutoitii from Mhengere Hill, Gorongosa, Mozambique. a: transverse section (TS) with four fibre vascular bundles (fvb) and poorly preserved parenchyma between; b: diagram of one of the fvbs in (a) of the reniform type (f – fibres, mx – metaxylum, p – phloem, px – protoxylum); c: close up of the vascular part of a fvb with 2 metaxylem elements and the collapsed cells to the lower left represents the phloem; d: fvb with 2 metaxylem elements, fibrous part to the left and parencymarous ground tissue to the right; e: lower magnification of fvb in (c); f: fvb with three metaxylem elements and phloem patch below; g: longitudinal section (LS) showing the vascular sections alternating with the fibrous sections; h: LS showing the horizontal thickening on the walls of the metaxylem vessels and a patch of parenchyma to the right (darker cells); i: spheroid echinate phytoliths that are typical of Hyphaene and Borassus.
Text-fig. 4. Taimyria triassica NAUGOLNYKH et MOGUTCHEVA gen. et sp. nov., holotype 4287/6. a: line drawing explaining female cone morphology after holotype; b: suggested reconstruction showing arrangement and vascularization of seed-bearing discs (left), and section through seed-bearing discs exhibiting seed attachment and marginal limb structure (right); c: seed scar structure (after Textfig. 3c), 1 – subepidermal and epidermal tissues under the cuticle, 2 – coaly tissues of mesophyll. Oval form at seed scar center is possible exit of conducting strand. Locality: Tsvetkov Cape; Lower Triassic, Induan; Keshin Formation. Scale bar 1 cm (a, b), 100 µm (c). in Taimyria Gen. Nov., A New Genus Of Evolutionary Advanced Gymnosperms From Triassic Of The Taimyr Peninsula, Siberia, Russia
Text-fig. 4. Taimyria triassica NAUGOLNYKH et MOGUTCHEVA gen. et sp. nov., holotype 4287/6. a: line drawing explaining female cone morphology after holotype; b: suggested reconstruction showing arrangement and vascularization of seed-bearing discs (left), and section through seed-bearing discs exhibiting seed attachment and marginal limb structure (right); c: seed scar structure (after Textfig. 3c), 1 – subepidermal and epidermal tissues under the cuticle, 2 – coaly tissues of mesophyll. Oval form at seed scar center is possible exit of conducting strand. Locality: Tsvetkov Cape; Lower Triassic, Induan; Keshin Formation. Scale bar 1 cm (a, b), 100 µm (c).
Dataset for: Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates
<p>Published in:<br> Nature Biomedical Engineering. doi: 10.1038/s41551-020-0566-1.</p> <p>Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates</p> <p>Ian S. Kinstlinger (1), Sarah H. Saxton (2), Gisele A. Calderon (1), Karen Vasquez Ruiz (1), David R. Yalacki (1), Palvasha R. Deme (1), Jessica E. Rosenkrantz (3), Jesse D. Louis-Rosenberg (3), Fredrik Johansson (2), Kevin D. Janson (1), Daniel W. Sazer (1), Saarang S. Panchavati (1), Karl-Dimiter Bissig (4), Kelly R. Stevens (2,5), and Jordan S. Miller (1)</p> <p>1 Department of Bioengineering, Rice University, Houston, TX, USA.<br> 2 Department of Bioengineering, University of Washington, Seattle, WA, USA.<br> 3 Nervous System, Palenville, NY, USA.<br> 4 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.<br> 5 Department of Pathology, University of Washington, Seattle, WA, USA</p> <p>Sacrificial templates for patterning perfusable vascular networks in engineered tissues have been constrained in architectural complexity, owing to the limitations of extrusion-based 3D-printing techniques. Here we show that cell-laden hydrogels can be patterned with algorithmically generated dendritic vessel networks and other complex hierarchical networks by using sacrificial templates made from laser-sintered carbohydrate powders. We quantified and modulated gradients of cell proliferation and cell metabolism emerging as a result of fluid convection through these networks and of diffusion of oxygen and metabolites out of them. We also show scalable strategies for the fabrication, perfusion culture and volumetric analysis of large tissue-like constructs with complex and heterogeneous internal vascular architectures. Perfusable dendritic networks in cell-laden hydrogels may help sustain thick and densely cellularized engineered tissues, and assist interrogations of the interplay between mass transport and tissue function.</p>
Vascular Damage and Repair - Are Small-diameter Vascular Grafts Still the "Holy Grail" of Tissue Engineering?
Open the record for dataset details and reuse information.
Evaluation of the Effect of IHHT on Vascular Stiffness and Elasticity of the Liver Tissue in Patients With MS.
ClinicalTrials.gov study NCT04791397. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Rosiglitazone on the Vascular Biology of Human Fat Tissue
ClinicalTrials.gov study NCT01150981. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Treatment of Osteoarthritis With the Stromal Vascular Fraction of Abdominal Adipose Tissue - a Pilot Study
ClinicalTrials.gov study NCT02697682. IPD Sharing: NO. Countries: 1. Publications: 1.
Intra-arterial Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Large Vascular Occlusion After Successful Mechanical Thrombectomy Recanalization
ClinicalTrials.gov study NCT05624190. IPD Sharing: YES. Countries: 1. Publications: 2.
Correlation Between NAFLD, Epicardial Adipose Tissue and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)
ClinicalTrials.gov study NCT01958411. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Adipose Tissue Derived Stromal Vascular Fraction (SVF) Application in Treatment of Long Bones Nonunion
ClinicalTrials.gov study NCT04340284. IPD Sharing: YES. Countries: 1. Publications: 4.
The Improving Effect of Autologous Stromal Vascular Fraction (SVF) in Adipose Tissue on Skin Grafting
ClinicalTrials.gov study NCT02546882. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Subcutaneous Injection of Autologous Adipose Tissue-derived Stromal Vascular Fraction Into the Fingers of Patients With Systemic Sclerosis
ClinicalTrials.gov study NCT02558543. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts
ClinicalTrials.gov study NCT04467671. IPD Sharing: YES. Countries: 1. Publications: 6.
Ovarian Rejuvenation Using Platelet Rich Plasma (PRP) & Autologous Tissue Stromal Vascular Fraction (tSVF) and Cell Enriched tSVF
ClinicalTrials.gov study NCT04444245. IPD Sharing: NO. Countries: 1. Publications: 63.
A Study to Determine the Tissue Properties, Vascular Physiology and Biochemical Milieu of Myofascial Trigger Points
ClinicalTrials.gov study NCT04045457. IPD Sharing: Not stated. Countries: 0. Publications: 4.
Vascularized Inter-positional Periosteal Connective-tissue Flap Versus Collagen Membrane in Guided Bone Regeneration
ClinicalTrials.gov study NCT05813340. IPD Sharing: NO. Countries: 1. Publications: 0.
Non Invasive and Non-Contact Imaging Of Tissue Oxygenation and Vascular Reactivity
ClinicalTrials.gov study NCT01573390. IPD Sharing: Not stated. Countries: 1. Publications: 32.
Tissue-specific reprogramming leads to angiogenic neutrophil specialization and tumor vascularization in colorectal cancer
GEO Series GSE232217. Mus musculus; Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing.
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