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ShareScore release 0.9.0
Dataset results
16 results for “WHIM”
WHiM-BC Dataset: Evolution of CSCs and non CSCs MCF-7 Migration in Wound Healing Assay
<p>The WHiM-BC Dataset has been utilized to train Deep Learning models for the prediction of migration capabilities of MCF-7 cells, facilitated by the <a href="https://github.com/frangam/wound-healing">Predicting Wound Healing Progress Framework (PWPF)</a>.</p> <p>The software can be accessed on GitHub: <a href="https://github.com/frangam/wound-healing">https://github.com/frangam/wound-healing</a>.</p> <p>Or you can download from Zenodo: <a href="https://doi.org/10.5281/zenodo.8130984">https://doi.org/10.5281/zenodo.8130984</a></p> <p>The dataset comprises two distinct parts:</p> <p>MCF-7 Monolayer Cells: This part includes photographs of 12 different wells taken at 0h, 3h, 6h, 9h, 12h, 24h, and 27h, marking the final time of wound closure.</p> <p>MCF-7 Spheres: This portion of the dataset mirrors the first, with images of 12 wells captured at the following time intervals: 0h, 3h, 6h, 9h, 12h, and 15h, indicating the closure time.</p> <p>The dataset consists of a total of (12<em>7) for the MCF-7 Monolayer Cells and (12</em>6) for the MCF-7 Spheres, amounting to a sum of photographs from both parts.</p> <p> </p> <p>If you utilize this tool in your research, please acknowledge it by citing the following reference:</p> <p><br><br>@article{Garcia-Moreno-PWPF,<br> title={Using Deep Learning for Predicting the Dynamic Evolution of Breast Cancer Migration},<br> author={Garcia-Moreno, Francisco Manuel and Ruiz-Espigares, Jesus and Marchal, Juan Antonio and Gutierrez-Naranjo, Miguel Angel},<br> year={2024},<br> journal={Computers in Biology and Medicine},<br> doi={10.1016/j.compbiomed.2024.108890},<br> note={\url{https://authors.elsevier.com/tracking/article/details.do?aid=108890&jid=CBM&surname=Garcia-Moreno}}<br>}</p> <p>And also cite our MCF-7 Dataset used to train our software:</p> <p><br>@misc{WHiM-BC_Dataset,<br> title={WHiM-BC Dataset: Evolution of CSCs and non CSCs MCF-7 Migration in Wound Healing Assay},<br> author={Garcia-Moreno, Francisco Manuel and Ruiz-Espigares, Jesus and Marchal, Juan Antonio and Gutiérrez-Naranjo, Miguel Ángel},<br> year={2023},<br> doi={10.5281/zenodo.8131123},<br> url={https://doi.org/10.5281/zenodo.8131123},<br> note = {version 1.0}<br>}<br><br></p>
Plerixafor Versus G-CSF in the Treatment of People With WHIM Syndrome
ClinicalTrials.gov study NCT02231879. IPD Sharing: NO. Countries: 1. Publications: 1.
A Dose Determination and Safety Study of X4P-001 (Mavorixafor) in Participants With Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome
ClinicalTrials.gov study NCT03005327. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Data from: Increased susceptibility of WHIM mice to Papillomavirus-induced disease is dependent upon immune cell dysfunction
Open the record for dataset details and reuse information.
Evaluating the Effects of Hormone Replacement Therapy on Brain Function (The WHIMS-MRI Study)
ClinicalTrials.gov study NCT00739869. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Examining the Relationship Between Hormone Therapy (HT) and Cognitive Function (The WHIMS-ECHO Study)
ClinicalTrials.gov study NCT00745056. IPD Sharing: YES. Countries: 1. Publications: 20.
Efficacy and Safety Study of Mavorixafor in Participants With Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome
ClinicalTrials.gov study NCT03995108. IPD Sharing: NO. Countries: 13. Publications: 1.
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
ClinicalTrials.gov study NCT00967785. IPD Sharing: NO. Countries: 1. Publications: 4.
The Women's Health Initiative Memory Study (The WHIMS Study)
ClinicalTrials.gov study NCT00685009. IPD Sharing: Not stated. Countries: 1. Publications: 5.
BKM120 Treated WHIMs_17 Model Cohort
GEO Series GSE148949. Homo sapiens. 54 samples. Type: Expression profiling by array.
Natural History of Human Papillomavirus (HPV) Infections in Mid-Adult Women (WHIM)
ClinicalTrials.gov study NCT01295242. IPD Sharing: Not stated. Countries: 1. Publications: 0.
WHIM syndrome–linked CXCR4 mutations impair lymphoid progenitor specification in mice
GEO Series GSE271225. Mus musculus. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A Retrospective and Prospective Natural History Study of Patients With WHIM Syndrome
ClinicalTrials.gov study NCT03087370. IPD Sharing: YES. Countries: 0. Publications: 0.
CXCL12 Stimulation of CXCR4-WHIM Transduced Waldenstrom's Macroglobulinemia cell line BCWM.1
GEO Series GSE83150. Homo sapiens. 24 samples. Type: Expression profiling by array.
WHIM Gene Expression Data_Update Through WHIM 26
GEO Series GSE41685. Mus musculus; Homo sapiens. 62 samples. Type: Expression profiling by array.
Dataset related to article "Reduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a novel CXCR4Leu317fsX3 mutation causing WHIM syndrome"
<p>This record contains raw data related to article "IReduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a novel CXCR4Leu317fsX3 mutation causing WHIM syndrome"</p><p>WHIM syndrome is an inherited immune disorder caused by an autosomal dominant heterozygous mutation in CXCR4.<i> </i>The disease is characterized by neutropenia/leukopenia (secondary to retention of mature neutrophils in bone marrow), recurrent bacterial infections, treatment-refractory warts, and hypogammaglobulinemia. All mutations reported in WHIM patients lead to the truncations in the C-terminal domain of CXCR4, R334X being the most frequent. This defect prevents receptor internalization, and enhances both calcium mobilization and ERK phosphorylation, resulting in increased chemotaxis in response to the unique ligand CXCL12. Here, we describe three patients presenting neutropenia and myelokathexis, but normal lymphocyte count and immunoglobulin levels, carrying a novel Leu317fsX3 mutation in CXCR4, leading to a complete truncation of its intracellular tail. The analysis of the L317fsX3 mutation in cells derived from patients and <i>in vitro</i> cellular models reveals unique signaling features when compared to R334X mutation. L317fsX3 mutation impairs CXCR4 downregulation and β-arrestin recruitment in response to CXCL12 and reduces other signaling events including ERK1/2 phosphorylation, calcium mobilization and chemotaxis, all processes, which are typically enhanced in cells carrying the R334X mutation. Our findings suggest that overall, the L317fsX3 mutation may be causative of a form of WHIM syndrome not associated with an augmented CXCR4 response to CXCL12.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.