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79 results for “Wistar; .”
HISTOLOGICAL EVALUATION OF THE EFFECTS OF ACTION BITTERS ON THE TESTES OF ADULT MALE WISTAR RATS
<p>Action Bitters, a popular herbal concoction, has been traditionally used to treat various health conditions, including those related to the male reproductive system. Despite its widespread use, there is a dearth of scientific evidence on its effects on the testes. This study aimed to investigate the histological changes in the testes of adult male Wistar rats following administration of Action Bitters.</p> <p><strong>Methods:</strong> Fifteen adult male Wistar rats were randomly divided into three groups (n = 5). Group A served as the normal control, while groups B and C received 10% (0.66ml/kg) and 5% (0.33ml/kg) lethal dose 50 (Ld50) of Action Bitters, respectively. The Ld50 values were calculated based on the median lethal dose of the herbal remedy. The rats were administered the herbal remedy for a period of one month, after which they were sacrificed, and their testes collected for histological examination.</p> <p><strong>Results:</strong> Microscopic examination of the testicular tissue samples revealed no evidence of abnormal cellular changes or tissue damage. The tissue samples appeared normal, with no signs of inflammation, necrosis, or apoptosis.</p> <p><strong>Discussion:</strong> The findings of this study suggest that Action Bitters does not induce histological changes in the testes of adult male Wistar rats. These results provide new insights into the potential mechanism of action of the herbal medication on testicular function. The study highlights the importance of considering both histological and biochemical assessments when evaluating the effects of herbal remedies on reproductive health.</p> <p><strong>Conclusion:</strong> This study contributes to the growing body of knowledge on the effects of herbal remedies on the male reproductive system. The findings suggest that Action Bitters may be a safe and effective herbal remedy for treating reproductive health issues, and further research is warranted to explore its potential benefits and mechanisms of action.</p>
Figure 8 in Effects of aluminum, copper, and titanium nanoparticles on some blood parameters in Wistar rats
Figure 8. AST levels in the serum of female rats orally exposed to Al2 O 3, TiO2, and CuO nanoparticles for 14 days. Details are given in Figure 1.
Figure 7 in Effects of aluminum, copper, and titanium nanoparticles on some blood parameters in Wistar rats
Figure 7. ALT levels in the serum of female rats orally exposed to Al2 O 3, TiO2, and CuO nanoparticles for 14 days. Details are given in Figure 1.given in Figure 1.
Figure 6 in Effects of aluminum, copper, and titanium nanoparticles on some blood parameters in Wistar rats
Figure 6. ALP levels in the serum of female rats orally exposed to Al2 O 3, TiO2, and CuO nanoparticles for 14 days. Details are given in Figure 1.
Figure 5 in Effects of aluminum, copper, and titanium nanoparticles on some blood parameters in Wistar rats
Figure 5. Total antioxidant levels in the serum of female rats orally exposed to Al2 O 3, TiO2, and CuO nanoparticles for 14 days. Details are given in Figure 1.
Figure 4 in Effects of aluminum, copper, and titanium nanoparticles on some blood parameters in Wistar rats
Figure 4. Total oxidant levels in the serum of female rats orally exposed to Al O, TiO, and CuO nanoparticles for 14 days. 2 3 2 Details are given in Figure 1.
Figure 3 in Effects of aluminum, copper, and titanium nanoparticles on some blood parameters in Wistar rats
Figure 3. The activity of Ca-ATPase in the erythrocytes of female rats orally exposed to Al O, TiO, and CuO nanoparticles for 14 2 3 2 days. Details are given in Figure 1.
Figure 1 in Effects of aluminum, copper, and titanium nanoparticles on some blood parameters in Wistar rats
Figure 1. The activity of Na,K-ATPase in the erythrocytes of female rats orally exposed to Al 2 O 3, TiO 2, and CuO nanoparticles for 14 days. Each point shows the mean of 6 rats and the standard errors. Statistical results and % alterations are given in the Table.
Mechanistic study on direct and indirect thyroid toxicity in male Wistar rats - Serum Metabolomics
<p>The present oral toxicity study in male Wistar rats is focusing on direct and indirect thyroid<br> toxicity. Biomaterials from this study were used to generate transcriptomics, proteomics,<br> and metabolomics data sets. Featuring a time- and concentration-resolved design<br> including recovery after treatment, this study allows investigating adaptive versus adverse<br> effects in several dimensions.<br> Two well-described test chemicals, i.e., Phenytoin and Propylthiouracil, were administered<br> at each two dose levels to male Wistar rats for 2 (Subset A) and 4 weeks via the diet<br> (Subset B). In addition, a recovery period of 2 weeks without test substance application was<br> included, in order to monitor reversibility of the induced effects (Subset C).<br> During the course of the study, blood samples were taken for metabolome analyses.</p>
The Effect of Bone Graft Substitute in Healing Fractures with Bone Defects Through Examination of Alkaline Phosphatase and Radiology in the Murine Model (Rattus norvegicus) Wistar strain
<p>Raw data for manuscript with the title <strong>The Effect of Bone Graft Substitute in Healing Fractures with Bone Defects Through Examination of Alkaline Phosphatase and Radiology in the Murine Model (<em>Rattus norvegicus</em>) Wistar strain </strong></p>
Wistar rat hippocampus CA1 pyramidal cell morphologies
<p>title : Reconstruction of hippocampus CA1 cell morphologies</p> <p>specimen : Rattus norvegicus</p> <p>sex : male</p> <p>strain : Wistar</p> <p>age : post-natal day 14-16</p> <p>This neuron was recorded and filled with biocytin (3 mg/ml) in a 300 µm thick coronal slice of rat hippocampus, using 2 - 10 MOhm patch pipettes. 3,3′-diaminobenzidine (DAB) was used for revelation. The slice was fixed and the cell reconstructed with Neurolucida using a 100x oil immersion objective.</p>
Wistar Rat
Drawing uploaded to scidraw.io on: 21 January 2020
Figure 1 from: Satria D, Sitorus P, Dalimunthe A, Waruwu SB, Asfianti V (2024) Oral acute toxicity study of ethanol extract of Mobe leaves (Artocarpus lacucha Buch-Ham) in Wistar rats. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e117500
Figure 1 Organ histopathology (Staining: Hematoxylin and eosin). (C: Normal control group treated with CMC Sodium 0.5%, TI: Treatment group treated with 2000 mg, TII: Treatment group treated with 5000 mg).
Figure 2 from: Satria D, Fauzi ZPA, Harahap U, Yuandani, Waruwu SB, Purnomo H (2024) Teratogenic effect of 1.3 bis (p-Hydroxyphenyl)urea on Wistar rats (Rattus norvegicus L.). Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e121947
Figure 2 Effect of 1.3 bis(p-Hydroxyphenyl)urea on external malformations. A. Normal fetus; B. Fetus with hematoma.
Figure 1 from: Satria D, Fauzi ZPA, Harahap U, Yuandani, Waruwu SB, Purnomo H (2024) Teratogenic effect of 1.3 bis (p-Hydroxyphenyl)urea on Wistar rats (Rattus norvegicus L.). Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e121947
Figure 1 Fetal body weight and length after being treated (data: mean ± SEM, *p < 0.05 significant compared to CMC Sodium 0.5% group control).
Figure 3 from: Satria D, Fauzi ZPA, Harahap U, Yuandani, Waruwu SB, Purnomo H (2024) Teratogenic effect of 1.3 bis (p-Hydroxyphenyl)urea on Wistar rats (Rattus norvegicus L.). Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e121947
Figure 3 Effect of compound 1.3 bis(p-Hydroxyphenyl)urea on skeletal malformations. A. Normal sternum; B. Abnormal sternum; C. The front paws and hind claws are normal; D. Abnormal front paws and hind claws.
Anti-angiogenic effect of the combination low-dose sorafenib and EGCG in HCC-induced Wistar rats
<p>VEGF and MVD raw material</p>
Raw data for research paper entitled "Effects of Acute Toluene Exposure on Oxidative Stress Parameters and Endothelial Markers in the Coronary Artery of Wistar Rats"
Open the record for dataset details and reuse information.
Supplementary material 1 from: Yusuf H, Kamarlis RK, Yusni Y, Fahriani M (2021) The anticancer activity of ethanol extract of Chromolaena odorata leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (Rattus novergicus). Pharmacia 68(2): 493-499. https://doi.org/10.3897/pharmacia.68.e63956
Table S1
The dataset of 'The effects of 3% binahong (Anredera cordifolia) leaf extract gel on the alveolar bone healing in post-extraction tooth socket wound in Wistar rats (Rattus norvegicus)'
<p>Background: Binahong (<em>Anredera cordifolia</em> (Ten.) STEENIS) is a widely available herbal plant in Indonesia and has been intensely researched for its healing abilities due to its biological activities, but few studied its capability in accelerating hard tissue healing in post-extraction sockets. The purpose of this study was to analyze the effects of 3% binahong leaf extract gel on the alveolar bone healing in the post-extraction sockets in Wistar rats.</p> <p>Methods: In this study, 48 male Wistar rats were randomly allocated to twelve groups. After the extraction of the left mandibular incisor, sockets in Group I to IV were given 3% binahong leaf extract gel, group V to VIII were given base gel, and group IX to XII were given Gengigel® for 14 days. The residual socket volume (RSV) and fibroblast proliferation were observed on the 3rd, 7th, and 14th day post-extraction, while the osteoblast and osteocyte proliferation were observed on the 7th, 14th, and 28th day post-extraction. The RSV data were analyzed using repeated measures ANOVA and one-way ANOVA, while the histopathological data were analyzed using one-way ANOVA.</p> <p>Results: The results showed that the binahong group had the lowest RSV and the highest fibroblast proliferation compared to the other groups on the 7th day (p<0.05) and the highest osteoblast and osteocyte proliferation compared to the other groups on the 14th day (p<0.05).</p> <p>Conclusion: The experiment showed that 3% binahong leaf extract gel could enhance alveolar bone healing by increasing the proliferation of fibroblasts, osteoblasts, and osteocytes.</p>
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