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18 results for “X-linked adrenoleukodystrophy”
Multi-omic approach to identify phenotypic modifiers underlying cerebral demyelination in X-linked adrenoleukodystrophy
<p>These are the data tables used to produce results in the publication:</p> <p>"Multi-omic approach to identify phenotypic modifiers underlying cerebral demyelination in X-linked adrenoleukodystrophy."<br> Phillip A. Richmond & Frans van der Kloet et al.</p> <p>Submitting to Frontiers in Cellular and Developmental Biology, 2020, Peroxisomal Special Issue. </p> <p>These tables include normalized measurements from four omics technologies, with no identifying information included. For details on processing, see the manuscript or contact:</p> <p>prichmond (at) cmmt (dot) ubc (dot) ca. </p> <p>Description of Files</p> <ul> <li>Sample mapping <ul> <li>20180314_sib_pairs.xlsx <ul> <li>Excel sheet describing family numbering, etc. used as a mapping table within the sheets below. </li> </ul> </li> </ul> </li> <li>Methylation: <ul> <li>DMRs_5_Families_ALL_0.10DB_Dec2019.csv <ul> <li>Significant methylated regions with delta beta at least 10 percent when a single family is left out</li> </ul> </li> <li>ALD_Deconvoluted_Betas_Dec2019.csv <ul> <li>All fitted betas for every subject (single CpG)</li> </ul> </li> <li>ALD_Limma_Final_Dec2019_CHR.csv <ul> <li>All fitted effects using limma modeling per CpG </li> </ul> </li> </ul> </li> <li>RNA: <ul> <li>Count_data.txt <ul> <li>The raw count table summed at the gene level using featureCounts.</li> </ul> </li> <li>Pvalues_all_23_01_2019.csv <ul> <li>All pvalues and log fold changes for the genes included in the modeling process (also with family left out)</li> </ul> </li> <li>Tmm_norm_counts_5_2_2020.csv <ul> <li>Tmm normalized RNA count data</li> </ul> </li> </ul> </li> <li>Proteomic <ul> <li>Report_Precursor_Peptides.xls <ul> <li>The proteomic data as an excel spreadsheet</li> </ul> </li> </ul> </li> <li>Pvalues_prot_13_3_2019.xlsx <ul> <li>The pvalues and log fold changes (also with family left out)</li> </ul> </li> <li>Lipids: <ul> <li>Lipid_data.csv <ul> <li>The lipid data (metabolites with missings are removed)</li> </ul> </li> <li>Pvalues_lipids.csv <ul> <li>Pvalues for the lipid data (also with family left out)</li> </ul> </li> </ul> </li> </ul> <p><br> NOTE: For use of these data files for processing and reproducing results of the manuscript, please see https://github.com/Phillip-a-richmond/ALD_Modifier_Project. </p> <p> </p>
The Effect of Bezafibrate on the Level of Very Long Chain Fatty Acids (VLCFA) in X-linked Adrenoleukodystrophy (X-ALD)
ClinicalTrials.gov study NCT01165060. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Modeling Macrophages Activation Pattern in X-linked Adrenoleukodystrophy, Metachromatic Leukodystrophy and Adult Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia
ClinicalTrials.gov study NCT04925349. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
SMART-ALD - A New Lifestyle Intervention to Improve Quality of Life in Women With X-linked Adrenoleukodystrophy (X-ALD)
ClinicalTrials.gov study NCT04687007. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Exercise Study of Function and Pathology for Women With X-linked Adrenoleukodystrophy
ClinicalTrials.gov study NCT01594853. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Transcriptome of human primary macrophages from X-linked adrenoleukodystrophy patients and healthy controls
GEO Series GSE217140. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
Treating Leg Symptoms in Women With X-linked Adrenoleukodystrophy
ClinicalTrials.gov study NCT05003648. IPD Sharing: UNDECIDED. Countries: 2. Publications: 0.
Safety and Pharmacodynamic Study of Sobetirome in X-Linked Adrenoleukodystrophy (X-ALD)
ClinicalTrials.gov study NCT01787578. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Validation of a Prognostic Biomarker Using Brain Diffusion MRI in X-linked Adrenoleukodystrophy
ClinicalTrials.gov study NCT05911919. IPD Sharing: YES. Countries: 0. Publications: 0.
Registry of X-linked Adrenoleukodystrophy
ClinicalTrials.gov study NCT05939232. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Pilot Study of Vitamin D in Boys With X-linked Adrenoleukodystrophy
ClinicalTrials.gov study NCT02595489. IPD Sharing: YES. Countries: 1. Publications: 0.
Disease Progression in Women With X-linked Adrenoleukodystrophy
ClinicalTrials.gov study NCT06178120. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Clinical Study in Male Pediatric Patients With Cerebral X-linked Adrenoleukodystrophy (Cald) to Assess the Effects of MIN-102 Treatment on Disease Progression Prior to Human Stem Cell Transplant (HS
ClinicalTrials.gov study NCT04528706. IPD Sharing: Not stated. Countries: 4. Publications: 0.
Quality of Life in Women with X-linked Adrenoleukodystrophy
ClinicalTrials.gov study NCT04675749. IPD Sharing: NO. Countries: 1. Publications: 0.
Transcriptome of human primary macrophages from X-linked adrenoleukodystrophy patients and healthy controls before and after long-term myelin phagocytosis
GEO Series GSE245235. Homo sapiens. 25 samples. Type: Expression profiling by high throughput sequencing.
Study to Assess PXL770 in Subjects With Adrenomyeloneuropathy (AMN) Form of X-linked Adrenoleukodystrophy (X-ALD or ALD)
ClinicalTrials.gov study NCT05146284. IPD Sharing: NO. Countries: 0. Publications: 0.
Study to Assess PXL065 in Subjects With Adrenomyeloneuropathy (AMN) Form of X-linked Adrenoleukodystrophy (X-ALD or ALD)
ClinicalTrials.gov study NCT05200104. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Nutritional status of children affected by X-linked adrenoleukodystrophy
<p>Children affected by X-linked adrenoleukodistrophy are not malnourished, but report a high body fat percentage.A low-fat diet could be adjuvant in the management of the disease.</p>
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