Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
13
datasets available to search
ShareScore release 0.9.0
Dataset results
13 results for “Yellow fever virus”
Genomic epidemiology unveils the dynamics and spatial corridor behind the Yellow Fever virus outbreak in Southern Brazil
<p>Despite the considerable morbidity and mortality of yellow fever virus (YFV) infections in Brazil our understanding of disease outbreaks is hampered by limited viral genomic data. Determining the timing and spatial corridors of YFV spread, as well as the geographic hotspots that link the endemic north of the country with epidemic extra-Amazonian regions, are central to predicting and preventing future outbreak and epidemics. Here, we tracked the recent spread of the virus by integrating genome sequences with both epidemiological and vector data. Through a combination of phylogenetic and epidemiological models we reconstructed the recent transmission history of YFV within different epidemic seasons in Brazil. A suitability index based on the highly domesticated <em>Aedes aegypti</em> was able to capture the seasonality of reported human infections. Spatial modelling revealed spatial hotspots with both past reporting and low vaccination coverage, which coincided with many of the largest urban centres in the Southeast. Phylodynamic analysis unravelled the circulation of three distinct YFV lineages, and provided proof of the directionality of a known spatial corridor of viral spread that connects the endemic North with the extra-Amazonian basin. This study illustrates that genomics linked with eco-epidemiology in a One Health framework can provide new insights into the landscape of YFV transmission, augmenting traditional approaches to infectious disease surveillance and control.</p>
Data from: Screening test for neutralizing antibodies against yellow fever virus, based on a flavivirus pseudotype
Given the possibility of yellow fever virus reintroduction in epidemiologically receptive geographic areas, the risk of vaccine supply disruption is a serious issue. New strategies to reduce the doses of injected vaccines should be evaluated very carefully in terms of immunogenicity. The plaque reduction test for the determination of neutralizing antibodies (PRNT) is particularly time-consuming and requires the use of a confinement laboratory. We have developed a new test based on the use of a non-infectious pseudovirus (WN/YF17D). The presence of a reporter gene allows sensitive determination of neutralizing antibodies by flow cytometry. This WN/YF17D test was as sensitive as PRNT for the follow-up of yellow fever vaccinees. Both tests lacked specificity with sera from patients hospitalized for acute Dengue virus infection. Conversely, both assays were strictly negative in adults never exposed to flavivirus infection or vaccination, and in patients sampled some time after acute Dengue infection. This WN/YF17D test will be particularly useful for large epidemiological studies and for screening for neutralizing antibodies against yellow fever virus.
Safety and Tolerability of an Antibody Against Yellow Fever Virus (TY014) in Humans
ClinicalTrials.gov study NCT03776786. IPD Sharing: NO. Countries: 1. Publications: 1.
Yellow Fever Virus Vaccine and Immune Globulin Study
ClinicalTrials.gov study NCT00254826. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Screening test for neutralizing antibodies against yellow fever virus, based on a flavivirus pseudotype
Open the record for dataset details and reuse information.
Trial of an Inactivated Yellow Fever Virus Vaccine
ClinicalTrials.gov study NCT05172544. IPD Sharing: NO. Countries: 1. Publications: 0.
Whole genome DNA methylation analysis of human CD8 T cell specific for the Yellow fever virus vaccine
GEO Series GSE75533. Homo sapiens. 4 samples. Type: Methylation profiling by high throughput sequencing.
CRISPR screen for interferon-alpha inducible inhibitors of yellow fever virus replication
GEO Series GSE121710. Homo sapiens. 2 samples. Type: Other.
Mitochondrial Hyperactivity and Reactive Oxygen Species Drive Innate Immunity to the Yellow Fever Virus-17D Live-Attenuated Vaccine
GEO Series GSE293880. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Characterization of T Cell Responses Following Yellow Fever Virus Vaccination in Healthy Adults
ClinicalTrials.gov study NCT00616356. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Integrative biology of patients acutely infected with yellow fever virus
GEO Series GSE243442. Homo sapiens. 55 samples. Type: Expression profiling by high throughput sequencing.
The yellow fever virus capsid protein is a potent suppressor of RNA silencing that binds double stranded RNA.
GEO Series GSE80691. Aedes aegypti. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
External RNA Control Consortium (ERCC) spikes in RNA sequencing (RNA-Seq) data normalization: transcriptome analysis of yellow fever virus-infected cells
GEO Series GSE99081. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.