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212 results for “Zika”
Inter-Chemical Correlation results for the study: HHEARx2017-1839 (Zika Virus Congenital Health Outcomes and the Impact of Maternal Environmental Exposures)
Title: Zika Virus Congenital Health Outcomes and the Impact of Maternal Environmental Exposures <br>Species: Homo sapiens <br>Number of samples: 2705 <br>Number of named analytes: 10 <br>Datasource url: https://hheardatacenter.mssm.edu/PublicFile/ViewPublicFile?projectid=61 <br>
TRATAMENTO DE NEUROPATIAS POR VÍRUS ZIKA USANDO L-CARNITINA ASSOCIADA OU NÃO A DEMAIS SUPLEMENTOS ANTIOXIDANTES EM GESTANTES E CRIANÇAS.
<p>Relato da possibilidade de uso da Carnitina, substância sintetizada a partir da lisina e metionina, apresentando-se como uma amina quarternária, podendo ser utilizada no tratamento por víruz zika durante a gestação.</p>
Data from: Temperature drives Zika virus transmission: evidence from empirical and mathematical models
<p>Temperature is a strong driver of vector-borne disease transmission. Yet, for emerging arboviruses we lack fundamental knowledge on the relationship between transmission and temperature. Current models rely on the untested assumption that Zika virus responds similarly to dengue virus, potentially limiting our ability to accurately predict the spread of Zika. We conducted experiments to estimate the thermal performance of Zika virus (ZIKV) in field-derived Aedes aegypti across eight constant temperatures. We observed strong, unimodal effects of temperature on vector competence, extrinsic incubation period, and mosquito survival. We used thermal responses of these traits to update an existing temperature-dependent model to infer temperature effects on ZIKV transmission. ZIKV transmission was optimized at 29oC, and had a thermal range of 22.7oC - 34.7oC. Thus, as temperatures move toward the predicted thermal optimum (29oC) due to climate change, urbanization, or seasonally, Zika could expand north and into longer seasons. In contrast, areas that are near the thermal optimum were predicted to experience a decrease in overall environmental suitability. We also demonstrate that the predicted thermal minimum for Zika transmission is 5oC warmer than that of dengue, and current global estimates on the environmental suitability for Zika are greatly over-predicting its possible range.</p>
Further analysis by ContentMine of OA Papers Returned by Querying EuropePMC with 'zika'
<p>Facts and metadata extracted from papers returned from querying EuropePMC with the phrase 'zika' using the ContentMine Cambridge pipeline. With dictionaries available at https://github.com/contentmine/dictionaries. Query and dictionaries used as of 2016-09-19.</p> <p>This dataset contains metadata and facts from 524 papers. A large number of the terms in the dictionaries used now contain wikidata IDs.</p> <p>Canary Version: 2ab2e9e7d95c2d6f81636739f383e52543befeff</p> <p>Dictionaries Version: 2498cf1bae660ae44437bcba388ef8436cc8554c</p>
Zika virus prM protein contains cholesterol binding motifs required for virus entry and assembly - Molecular Dynamics Simulation Dataset
<p>The molecular dynamics (MD) simulation dataset. The contents:</p> <ul> <li><strong>5ire_BIOMT_expanded.pdb</strong>: The complete biological assembly of the cryo-EM structure of Zika Virus (PDB ID:5IRE) </li> <li><strong>5ire_Mprotein_BIOMT_expanded.pdb</strong>: The M proteins extracted from the complete biological assembly of the cryo-EM structure of Zika Virus (PDB ID:5IRE). The biological assembly shows the dimeric organization of M proteins.</li> <li><strong>0chol.zip, 10chol.zip, 20chol.zip, and 30chol.zip</strong> contain simulation input and output files for the simulated membrane compositions: 0:100, 10:90, 20:80, 30:70 (mol%:mol%) Cholesterol:POPC, respectively. <ul> <li>In each zip file, there are 5 directories: <strong>wt, R253L+F257A, R253L+F257S, K275L+Y278A, K275L+Y278S</strong> corresponding to each simulated M protein dimer variant: wild type, CARC 2-A, CARC 2-S, CARC 3-A, and CARC 3-S. In each directory, there are the following files: <ul> <li><strong>toppar</strong>: This directory contains all force field topologies and parameters</li> <li><strong>topol.top</strong>: GROMACS topology (top) file</li> <li><strong>index.ndx</strong>: GROMACS index (ndx) file</li> <li><strong>prod.mdp</strong>: GROMACS MD parameters (mdp) file</li> <li><strong>0, 1, 2, 3, 4, 5, 6, 7, 8, 9</strong>: These directories contain the simulation inputs and outputs for each simulation repeat. In each of these directories, there are the following files: <ul> <li><strong>t0.pdb</strong>: The pdb file of the starting coordinates</li> <li><strong>prod0.tpr</strong>: GROMACS binary run input (tpr) file </li> <li><strong>prod0.edr</strong>: GROMACS energy (edr) file</li> <li><strong>prod0.gro</strong>: GROMACS output coordinates and velocities after 1 microsecond of simulation</li> <li><strong>prod0.cpt</strong>: GROMACS checkpoint file after 1 microsecond of simulation</li> <li><strong>noW.pdb</strong>: The pdb file of the starting coordinates with all water molecules removed</li> <li><strong>noW.xtc</strong>: GROMACS compressed trajectory (xtc) file with all water molecules removed</li> </ul> </li> </ul> </li> </ul> </li> </ul>
Safety, Immunogenicity, and Dose Ranging Study of Inactivated Zika Virus Vaccine in Healthy Participants
ClinicalTrials.gov study NCT03343626. IPD Sharing: YES. Countries: 2. Publications: 2.
Data from: Temperature drives Zika virus transmission: evidence from empirical and mathematical models
Open the record for dataset details and reuse information.
An investigation into the knowledge, perceptions and role of personal protective technologies in Zika prevention in Colombia
<p>To gain an insight into the knowledge and concerns of pregnant women surrounding Zika and their opinions regarding personal protective technologies, particularly repellent clothing, a focus group study was carried out with pregnant women, women of reproductive age, and semi-structured interviews with their male partners in two cities in Colombia. The qualitative data files made available here are the transcripts for the manuscript developed from this research. </p>
The impact of news exposure on collective attention in the United States during the 2016 Zika epidemic
<p>This repository contains the data of the study "The impact of news exposure on collective attention in the United States during the 2016 Zika epidemic".</p> <p><strong>Epidemiological data</strong></p> <p>The folder <em>zika_USA_weekly_cases_2016.zip </em>contains weekly ZIKV incidence counts reported by the US Centers for Disease Control and Prevention in 2016, by state. Data were extracted from reports made publicly available by the CDC at: <a href="https://zenodo.org/record/584136#.Xk07-RNKjOQ">https://zenodo.org/record/584136#.Xk07-RNKjOQ</a> </p> <p><strong>Web news data</strong></p> <p>The file <em>news_GDELT_data.csv.gz </em>contains all news items extracted from the GDELT platform (<a href="https://www.gdeltproject.org/">https://www.gdeltproject.org/</a>) matching <em>TAX_DISEASE_ZIKA </em>as a Theme, and <em>United_States</em> as a Location in the GDELT platform. </p> <p><strong>TV closed captions</strong></p> <p>The file <em>zika_TV_mentions_dataframe.csv </em>contains all the TV news items of 2016 matching the word ``Zika" in the TV News Archive https://archive.org/details/tv</p> <p><strong>Wikipedia pageview counts</strong></p> <p>Dataset 1: <em>wikipedia_dataset1_zika_daily_pageview_usa.csv</em></p> <p>Content of each line of the dataset: day, pageview_count</p> <p>The dataset contains the daily number of pageview counts of 128 different Wikipedia pages related to the Zika virus (aggregated and summed to total) originated in the United States, from January 1st to December 31st, 2016.</p> <p>Dataset 2: <em>wikipedia_dataset2_zika_daily_pageview_bystate.zip</em></p> <p>Content of each line of the dataset: day, pageview_count, state</p> <p>The dataset contains the daily number of pageview counts of 128 different Wikipedia pages related to the Zika virus (aggregated and summed to total) originated in the United States, disaggregated by state, from January 1st to December 31st, 2016.</p> <p>Dataset 3: <em>wikipedia_dataset3_zika_pagecount_by_city.csv</em></p> <p>Content of each line of the dataset: US_city, pageview_count_Zika,pageview_count_total</p> <p>The dataset contains the total number of pageview counts of 128 different Wikipedia pages related to the Zika virus (pageview_count_Zika) originated in 788 cities (US_city) of the United States with a population larger than 40,000 in 2016.The dataset also contains the total number of pageview counts to all Wikipedia pages (all Wikipedia projects, pageview_count_total) originated in 788 cities (US_city) of the United States with a population larger than 40,000 in 2016."</p>
Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations
<p>The worldwide variation of <em>Aedes aegypti </em>susceptibility to ZIKV infection was investigated using a panel of 14 laboratory colonies recently established from field-collected specimens.</p>
Data from: Preventing Zika virus infection during pregnancy using a seasonal window of opportunity for conception
It has come to light that Zika virus (ZIKV) infection during pregnancy can result in trans-placental transmission to the fetus along with fetal death, congenital microcephaly and/or Central Nervous System (CNS) malformations. There are projected to be > 9, 200, 000 births annually in countries with ongoing ZIKV transmission. In response to the ZIKV threat, the World Health Organization (WHO) is strategically targeting prevention of infection in pregnant women and funding contraception in epidemic regions. I propose that the damaging effects of ZIKV can be reduced using a seasonal window of opportunity for conception that may minimize maternal exposure. Like other acute viral infections—including the related flavivirus, dengue virus (DENV)—the transmission of ZIKV is anticipated to be seasonal. By seasonally planning pregnancy, this aspect of pathogen ecology can be leveraged to align sensitive periods of gestation with the low-transmission season.
ContentMine Analysis of Papers from EuPMC query zika
<p>Facts and metadata extracted from papers returned from querying EuropePMC with the phrase 'zika' using the ContentMine Cambridge pipeline. With dictionaries available at https://github.com/contentmine/dictionaries. Query and dictionaries used as of 2016-08-31</p>
Data from: Spatiotemporal incidence of Zika and associated environmental drivers for the 2015-2016 epidemic in Colombia
Despite a long history of mosquito-borne virus epidemics in the Americas, the impact of the Zika virus (ZIKV) epidemic of 2015-2016 was unexpected. The need for scientifically informed decision-making is driving research to understand the emergence and spread of ZIKV. To support that research, we assembled a data set of key covariates for modeling ZIKV transmission dynamics in Colombia, where ZIKV transmission was widespread and the government made incidence data publically available. On a weekly basis between January 1, 2014 and October 1, 2016 at three administrative levels, we collated spatiotemporal Zika incidence data, nine environmental variables, and demographic data into a single downloadable database. These new datasets and those we identified, processed, and assembled at comparable spatial and temporal resolutions will save future researchers considerable time and effort in performing these data processing steps, enabling them to focus instead on extracting epidemiological insights from this important data set. Similar approaches could prove useful for filling data gaps to enable epidemiological analyses of future disease emergence events.
Electronic Supplementary Data to "Zika vector competence data reveals risks of outbreaks: the contribution of the European ZIKAlliance project"
<p>Electronic Supplementary Data to "Zika vector competence data reveals risks of outbreaks: the contribution of the European ZIKAlliance project"</p>
Minimal Action Path results between two confirmations of a Zika virus
Open the record for dataset details and reuse information.
The Aedes aegypti RNA interference response against Zika virus in the context of co-infection with dengue and chikungunya viruses
<p>This is the corresponding data of the Publication in Plos Neglected tropical diseases.</p> <p>Zika virus (ZIKV) is a mosquito-borne human-pathogenic arbovirus of the <em>Flaviviridae</em> family, genus <em>Flavivirus</em>. Other arboviruses, including dengue (DENV) or chikungunya (CHIKV) virus, can occur in the same regions as ZIKV and are also transmitted by <em>Aedes aegypti</em>. Notably, it has been shown that these viruses can co-infect this mosquito, andco-transmission occurs. Such processes may add to the serious public health issues already linked to those pathogens. Arbovirus infections in mosquitoes are controlled through an immune response called RNA interference (RNAi). It is however unknown whether immune responses changs when a mosquito is exposed to a co-infection of ZIKV with either DENV or CHIKV. In this study, we provide evidence that ZIKV co-infections with CHIKV or DENV are similarly well controlled by RNAi as single infections. These findings give new insights into the dynamics of arboviral co-infections in mosquito vectors that increase our understanding of co-infection scenarios during arbovirus outbreaks.</p>
MM and QMMM trayectories from "Conformational Changes and ATP Hydrolysis in Zika Helicase. The Molecular Basis of a Biomolecular Motor Unveiled by Multiscale Simulations"
<p>Here are provided two trayectories from the results of "Conformational Changes and ATP Hydrolysis in Zika Helicase. The Molecular Basis of a Biomolecular Motor Unveiled by Multiscale Simulations".</p> <p><em>ZikaNS3h-MMtrajectory.nc</em> contains a Molecular Mechanics MD simulation of the system with ATP bound to the active site.</p> <p><em>TS1-mech1-QMMMtrajectory.nc</em> contains a QMMM MD simulation of the system with TS1 of the base-assisted mechanism bound to the active site.</p> <p><em>ZikaNS3h.prmtop</em> is the parameter file.</p> <p> </p>
Study in Healthy Volunteers Evaluating Safety and Pharmacokinetics of Zika Virus Immune Globulin (ZIKV-IG)
ClinicalTrials.gov study NCT03624946. IPD Sharing: NO. Countries: 1. Publications: 1.
Sylvatic Transmission of Zika, Dengue, and Chikungunya Viruses in Thailand and Cambodia
ClinicalTrials.gov study NCT04434846. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Safety and Immunogenicity of a Novel Vaccine Formulation MV-ZIKA-RSP (V187-001)
ClinicalTrials.gov study NCT04033068. IPD Sharing: YES. Countries: 1. Publications: 1.
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OpenNeuro
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