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166 results for “Zika virus”
Inter-Chemical Correlation results for the study: HHEARx2017-1839 (Zika Virus Congenital Health Outcomes and the Impact of Maternal Environmental Exposures)
Title: Zika Virus Congenital Health Outcomes and the Impact of Maternal Environmental Exposures <br>Species: Homo sapiens <br>Number of samples: 2705 <br>Number of named analytes: 10 <br>Datasource url: https://hheardatacenter.mssm.edu/PublicFile/ViewPublicFile?projectid=61 <br>
Data from: Temperature drives Zika virus transmission: evidence from empirical and mathematical models
<p>Temperature is a strong driver of vector-borne disease transmission. Yet, for emerging arboviruses we lack fundamental knowledge on the relationship between transmission and temperature. Current models rely on the untested assumption that Zika virus responds similarly to dengue virus, potentially limiting our ability to accurately predict the spread of Zika. We conducted experiments to estimate the thermal performance of Zika virus (ZIKV) in field-derived Aedes aegypti across eight constant temperatures. We observed strong, unimodal effects of temperature on vector competence, extrinsic incubation period, and mosquito survival. We used thermal responses of these traits to update an existing temperature-dependent model to infer temperature effects on ZIKV transmission. ZIKV transmission was optimized at 29oC, and had a thermal range of 22.7oC - 34.7oC. Thus, as temperatures move toward the predicted thermal optimum (29oC) due to climate change, urbanization, or seasonally, Zika could expand north and into longer seasons. In contrast, areas that are near the thermal optimum were predicted to experience a decrease in overall environmental suitability. We also demonstrate that the predicted thermal minimum for Zika transmission is 5oC warmer than that of dengue, and current global estimates on the environmental suitability for Zika are greatly over-predicting its possible range.</p>
Zika virus prM protein contains cholesterol binding motifs required for virus entry and assembly - Molecular Dynamics Simulation Dataset
<p>The molecular dynamics (MD) simulation dataset. The contents:</p> <ul> <li><strong>5ire_BIOMT_expanded.pdb</strong>: The complete biological assembly of the cryo-EM structure of Zika Virus (PDB ID:5IRE) </li> <li><strong>5ire_Mprotein_BIOMT_expanded.pdb</strong>: The M proteins extracted from the complete biological assembly of the cryo-EM structure of Zika Virus (PDB ID:5IRE). The biological assembly shows the dimeric organization of M proteins.</li> <li><strong>0chol.zip, 10chol.zip, 20chol.zip, and 30chol.zip</strong> contain simulation input and output files for the simulated membrane compositions: 0:100, 10:90, 20:80, 30:70 (mol%:mol%) Cholesterol:POPC, respectively. <ul> <li>In each zip file, there are 5 directories: <strong>wt, R253L+F257A, R253L+F257S, K275L+Y278A, K275L+Y278S</strong> corresponding to each simulated M protein dimer variant: wild type, CARC 2-A, CARC 2-S, CARC 3-A, and CARC 3-S. In each directory, there are the following files: <ul> <li><strong>toppar</strong>: This directory contains all force field topologies and parameters</li> <li><strong>topol.top</strong>: GROMACS topology (top) file</li> <li><strong>index.ndx</strong>: GROMACS index (ndx) file</li> <li><strong>prod.mdp</strong>: GROMACS MD parameters (mdp) file</li> <li><strong>0, 1, 2, 3, 4, 5, 6, 7, 8, 9</strong>: These directories contain the simulation inputs and outputs for each simulation repeat. In each of these directories, there are the following files: <ul> <li><strong>t0.pdb</strong>: The pdb file of the starting coordinates</li> <li><strong>prod0.tpr</strong>: GROMACS binary run input (tpr) file </li> <li><strong>prod0.edr</strong>: GROMACS energy (edr) file</li> <li><strong>prod0.gro</strong>: GROMACS output coordinates and velocities after 1 microsecond of simulation</li> <li><strong>prod0.cpt</strong>: GROMACS checkpoint file after 1 microsecond of simulation</li> <li><strong>noW.pdb</strong>: The pdb file of the starting coordinates with all water molecules removed</li> <li><strong>noW.xtc</strong>: GROMACS compressed trajectory (xtc) file with all water molecules removed</li> </ul> </li> </ul> </li> </ul> </li> </ul>
Safety, Immunogenicity, and Dose Ranging Study of Inactivated Zika Virus Vaccine in Healthy Participants
ClinicalTrials.gov study NCT03343626. IPD Sharing: YES. Countries: 2. Publications: 2.
Data from: Temperature drives Zika virus transmission: evidence from empirical and mathematical models
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Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations
<p>The worldwide variation of <em>Aedes aegypti </em>susceptibility to ZIKV infection was investigated using a panel of 14 laboratory colonies recently established from field-collected specimens.</p>
Data from: Preventing Zika virus infection during pregnancy using a seasonal window of opportunity for conception
It has come to light that Zika virus (ZIKV) infection during pregnancy can result in trans-placental transmission to the fetus along with fetal death, congenital microcephaly and/or Central Nervous System (CNS) malformations. There are projected to be > 9, 200, 000 births annually in countries with ongoing ZIKV transmission. In response to the ZIKV threat, the World Health Organization (WHO) is strategically targeting prevention of infection in pregnant women and funding contraception in epidemic regions. I propose that the damaging effects of ZIKV can be reduced using a seasonal window of opportunity for conception that may minimize maternal exposure. Like other acute viral infections—including the related flavivirus, dengue virus (DENV)—the transmission of ZIKV is anticipated to be seasonal. By seasonally planning pregnancy, this aspect of pathogen ecology can be leveraged to align sensitive periods of gestation with the low-transmission season.
Minimal Action Path results between two confirmations of a Zika virus
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The Aedes aegypti RNA interference response against Zika virus in the context of co-infection with dengue and chikungunya viruses
<p>This is the corresponding data of the Publication in Plos Neglected tropical diseases.</p> <p>Zika virus (ZIKV) is a mosquito-borne human-pathogenic arbovirus of the <em>Flaviviridae</em> family, genus <em>Flavivirus</em>. Other arboviruses, including dengue (DENV) or chikungunya (CHIKV) virus, can occur in the same regions as ZIKV and are also transmitted by <em>Aedes aegypti</em>. Notably, it has been shown that these viruses can co-infect this mosquito, andco-transmission occurs. Such processes may add to the serious public health issues already linked to those pathogens. Arbovirus infections in mosquitoes are controlled through an immune response called RNA interference (RNAi). It is however unknown whether immune responses changs when a mosquito is exposed to a co-infection of ZIKV with either DENV or CHIKV. In this study, we provide evidence that ZIKV co-infections with CHIKV or DENV are similarly well controlled by RNAi as single infections. These findings give new insights into the dynamics of arboviral co-infections in mosquito vectors that increase our understanding of co-infection scenarios during arbovirus outbreaks.</p>
Study in Healthy Volunteers Evaluating Safety and Pharmacokinetics of Zika Virus Immune Globulin (ZIKV-IG)
ClinicalTrials.gov study NCT03624946. IPD Sharing: NO. Countries: 1. Publications: 1.
Sylvatic Transmission of Zika, Dengue, and Chikungunya Viruses in Thailand and Cambodia
ClinicalTrials.gov study NCT04434846. IPD Sharing: Not stated. Countries: 1. Publications: 3.
VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents
ClinicalTrials.gov study NCT03110770. IPD Sharing: NO. Countries: 9. Publications: 4.
Data from: Preventing Zika virus infection during pregnancy using a seasonal window of opportunity for conception
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FIGURE 2 in The Asian tiger mosquito, Aedes (Stegomyia) albopictus (Skuse), a vector of dengue, chikungunya and zika viruses, reaches Portugal (Diptera: Culicidae)
FIGURE 2. Portuguese Aedes albopictus females seeking human blood. Note characteristic scutal white stripe, distinct silvery-white scales on the maxillary palpi and tarsi, as well as narrow scales over the wing root and silvery-white basolateral abdominal tergal markings.
FIGURE 1 in The Asian tiger mosquito, Aedes (Stegomyia) albopictus (Skuse), a vector of dengue, chikungunya and zika viruses, reaches Portugal (Diptera: Culicidae)
FIGURE 1. Distribution of Aedes albopictus in the Iberian Península. In green, distribution in Spain according to Collantes et al. (2016). In red, highlighted by arrow, new occurrence in Portugal.
FIGURE 3 in The Asian tiger mosquito, Aedes (Stegomyia) albopictus (Skuse), a vector of dengue, chikungunya and zika viruses, reaches Portugal (Diptera: Culicidae)
FIGURE 3. Biting activity of Ae. albopictus assessed by human-bait catches. Specimens arriving to bite were captured every 15 minutes to avoid recapture. The x axis is a timeline of 15-minute intervals; the y axis is an average of the three days of sampling.
Pilot Study to Detect Zika Virus in Sperm
ClinicalTrials.gov study NCT02874456. IPD Sharing: NO. Countries: 1. Publications: 1.
A Phase 1, First-in-human, Double-blinded, Randomized, Placebo-controlled Trial of a Zika Virus Purified Inactivated Vaccine (ZPIV) With Alum Adjuvant in Healthy Flavivirus-naive and Flavivirus-Primed
ClinicalTrials.gov study NCT02963909. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA085-00-VP, in Healthy Adults
ClinicalTrials.gov study NCT02840487. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF)
ClinicalTrials.gov study NCT03255369. IPD Sharing: YES. Countries: 1. Publications: 5.
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