Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
322
datasets available to search
ShareScore release 0.9.0
Dataset results
322 results for “active ageing”
Sex and Age Impact CD4+ T Cell Susceptibility to HIV In Vitro Through Cell Activation Dynamics
<p>Cellular composition and the responsiveness of the immune system evolve upon aging and are influenced by biological sex. CD4+ T cells from women living with HIV exhibit a decreased viral replication ex vivo compared to men's. We, thus, hypothesized that these findings could be recapitulated in vitro and infected primary CD4+ T cells with HIV-based vectors pseudotyped with VSV-G or HIV envelopes. We used cells isolated from twenty donors to interrogate the effect of sex and age on permissiveness over a six-day activation kinetics. Our data identified an increased permissiveness to HIV between 24 and 72 h post-stimulation. Sex- and age-based analyses at these time points showed an increased susceptibility to HIV of the cells isolated from males and from donors over 50 years of age, respectively. A parallel assessment of surface markers' expression revealed higher frequencies of activation marker CD69 and of immune checkpoint inhibitors (PD-1 and CTLA-4) in the cells from highly permissive donors. Furthermore, positive correlations were identified between the expression kinetics of CD69, PD-1 and CTLA-4 and HIV expression kinetics. The cell population heterogeneity was assessed using a single-cell RNA-Seq analysis and no cell subtype enrichment was identified according to sex. Finally, transcriptomic analyses further highlighted the role of activation in those differences with enriched activation and cell cycle gene sets in male and older female cells. Altogether, this study brought further evidence about the individual features affecting HIV replication at the cellular level and should be considered in latency reactivation studies for an HIV cure.</p>
BRAIN Journal-The Presence and Activity on Facebook of the Informative Travel Organizations in Romania-Figure 4. Facebook adoption rate by age group in Romania
<p>Also, according to Facebrands statistics of 15 October 2015, the Facebook penetration rate in the population is 39.76% and in the total number of Romanian Internet users is 82.97%. The statistics infirm the preconceived ideas of skeptics that the websites of socialization have no relevance for tourism organizations because the contained information in these websites is unstructured, inconsistent in terms of content and irrelevant for tourism, or newer, the ideas of those who believe that the majority of Facebook users are young and very young (under 18). From Figure 4 we can see that the segment of major users (over 18 years) totals 88.3% of the total number of Facebook users and these users may have at any time the quality of tourists.</p>
Artificial Intelligence and the Future of Smart Cities-Figure 10. Respondents' opinions about the use of robots in different activities (grouped by age)
<p>Question 14 was used to evaluate the respondents’ opinions about the use of robots in the following activities: performing medical surgeries, child care, supply of consumer goods, driving a car, assistance in performing tasks at work and cleaning (Figure 10). The respondents feel most confident and safe to use robots for cleaning (M=4.18, SD=1.07) and for assistance in performing tasks at work (M=4.12, SD=1.05) and less confident and safe to use robots for driving a car (M=3.87, SD=1.11), for supply of consumer goods (M=3.81, SD=.81) and performing medical surgeries (M=3.68, SD=.92) The child care obtained the lower score (M=2.00, SD=86).</p>
Figure 5 in Diurnal activity pattern of age-sex groups of a small and fragmented population of Blackbuck (Antilope cervicapra L.) in Western Haryana, India
Figure 5. Behavioural activities recorded for sub adult male vs. total time spent during different season(s).
Figure 6 in Diurnal activity pattern of age-sex groups of a small and fragmented population of Blackbuck (Antilope cervicapra L.) in Western Haryana, India
Figure 6. Behavioural activities recorded for sub adult female vs. total time spent during different season(s).
Figure 3 in Diurnal activity pattern of age-sex groups of a small and fragmented population of Blackbuck (Antilope cervicapra L.) in Western Haryana, India
Figure 3. Behavioural activities recorded for adult male vs. total time spent during different season(s).
Figure 4 in Diurnal activity pattern of age-sex groups of a small and fragmented population of Blackbuck (Antilope cervicapra L.) in Western Haryana, India
Figure 4. Behavioural activities recorded for adult female vs. total time spent during different season(s).
Figure 8 in Diurnal activity pattern of age-sex groups of a small and fragmented population of Blackbuck (Antilope cervicapra L.) in Western Haryana, India
Figure 8. Average % time spent annually versus activities by different age sex group (Error bars with standard error and treatment bars with different letters differ significantly at P ≤ 0.05 based on Duncan Multiple Range Test).
Figure 7 in Diurnal activity pattern of age-sex groups of a small and fragmented population of Blackbuck (Antilope cervicapra L.) in Western Haryana, India
Figure 7. Major behavioural activities vs. total time spent on each activity by different age-sex animal.
Temperature Activates Contact Aging in Silica Nanocontacts
<p>Data presented in the CECAM workshop: Emergence of surface and interface structure from friction, fracture and deformation ( link: cecam.org/index.php/workshop-details/215). </p> <p>Here we unravel the temperature dependence of both static friction and contact stiffness on a silica contact. Further in-depth details are provided in the associated peer-reviewed freely available publication (https://doi.org/10.1103/PhysRevX.9.041045).</p> <p> </p>
Social network shrinking is explained by active and passive effects but not increasing selectivity with age in wild macaques
<p>Evidence of social disengagement, network narrowing, and social selectivity with advancing age in several non-human animals challenges our understanding of the causes of social ageing. Natural animal populations are needed to test whether social ageing and selectivity occur under natural predation and extrinsic mortality pressures, and longitudinal studies are particularly valuable to disentangle the contribution of within-individual ageing from the demographic processes that shape social ageing at the population level. Data on wild Assamese macaques (<em>Macaca assamensis</em>) were collected between 2013 and 2020 at the Phu Khieo Wildlife Sanctuary, Thailand. We investigated the social behaviour of 61 adult females observed for 13,270 hours to test several mechanistic hypotheses of social ageing and evaluated the consistency between patterns from mixed-longitudinal and within-individual analyses. With advancing age, females reduced the size of their social network, which could not be explained by an overall increase in the time spent alone, but by an age-related decline in mostly active, but also passive, behaviour, best demonstrated by within-individual analyses. A selective tendency to approach preferred partners was maintained into old age but did not increase. Our results contribute to our understanding of the driver of social ageing in natural animal populations and suggest that social disengagement and selectivity follow independent trajectories during ageing.</p>
Age-specific activation patterns and inter-subject similarity during verbal working-memory maintenance and Cognitive Reserve
<p>Cognitive Reserve, according to a recent consensus definition of the NIH-funded Reserve and Resilience collaboratory (<a href="https://reserveandresilience.com/">https://reserveandresilience.com/</a>), is constituted by any mechanism contributing to cognitive performance beyond, or interacting with, brain structure in the widest sense. To identity multivariate activation patterns fulfilling this postulate, we investigated a verbal Sternberg fMRI task and imaged 181 people with age coverage in the ranges 20-30 (44 participants) and 55-70 (137 participants). Beyond task performance, participants were characterized in terms of demographics, and neuropsychological assessments of vocabulary, episodic memory, perceptual speed, and abstract fluid reasoning. Participants studied an array of either 1, 3, or 6 upper-case letters for 3 seconds (=encoding phase), then a blank fixation screen was presented for 7 seconds (=maintenance phase), to be probed with a lower-case letter to which they responded with a differential button press whether the letter was part of the studied array or not (=retrieval phase). We focused on identifying maintenance-related activation patterns showing memory-load increases in pattern score on an individual-participant level for both age groups. We found such a pattern that increased with memory load for all but one person in the young participants (p<0.001), and such a pattern for all participants in the older group (p<0.001). Both patterns showed broad topographic similarities; however, relationships to task performance and neuropsychological characteristics were markedly different and point to individual differences in Cognitive Reserve. Beyond the derivation of group-level activation patterns, we also investigated the inter-subject spatial similarity of individual working-memory rehearsal patterns in the older participants' group as a function of neuropsychological and task performance, education and mean cortical thickness. Higher task accuracy and neuropsychological function was reliably associated with higher inter-subject similarity of individual-level activation patterns in older participants.</p>
Figure 1 in Diurnal activity pattern of age-sex groups of a small and fragmented population of Blackbuck (Antilope cervicapra L.) in Western Haryana, India
Figure 1. Map of the study site.
Figure 2 in Diurnal activity pattern of age-sex groups of a small and fragmented population of Blackbuck (Antilope cervicapra L.) in Western Haryana, India
Figure 2. (a) Adult male, (b) Sub adult female, (c) Adult females and sub adult
FGF-2-dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis
<p><span><span><span><span><span><span><span><span><span><span><span>Aged skeletal muscle is markedly affected by fatty muscle infiltration and strategies to reduce the occurrence of intramuscular adipocytes are urgently needed. Here, we show that fibroblast growth factor-2 (FGF-2) not only stimulates muscle growth, but also promotes intramuscular adipogenesis. Using multiple screening assays upstream and downstream of microRNA (miR)-29a signaling, we located the secreted protein and adipogenic inhibitor SPARC to an FGF-2 signaling pathway that is conserved between skeletal muscle cells from mice and humans and that is activated in skeletal muscle of aged mice and humans. FGF-2 induces the miR-29a/SPARC axis through transcriptional activation of FRA-1, which binds and activates an evolutionary conserved AP-1 site element proximal in the miR-29a promoter. Genetic deletions in muscle cells and AAV-mediated overexpression of FGF-2 or SPARC in mouse skeletal muscle revealed that this axis regulates differentiation of fibro/adipogenic progenitors <i>in vitro</i> and intramuscular adipose tissue (IMAT) formation <i>in vivo</i>. Skeletal muscle from human donors aged > 75 years versus < 55 years showed activation of FGF-2-dependent signaling and increased IMAT. Thus, our data highlights a disparate role of FGF-2 in adult skeletal muscle and reveals a novel pathway to combat fat accumulation in aged human skeletal muscle.</span></span></span></span></span></span></span></span></span></span></span></p>
Activate For Life: mHealth Intervention To Address Pain And Fatigue In Low-income Older Adults Aging In Place
ClinicalTrials.gov study NCT03853148. IPD Sharing: NO. Countries: 1. Publications: 2.
A Study to Evaluate the Pharmacokinetics, Safety, Tolerability, and Antiviral Activity of Rilpivirine (TMC278) in Human Immunodeficiency Virus Infected Adolescents and Children Aged Greater Than or Eq
ClinicalTrials.gov study NCT00799864. IPD Sharing: Not stated. Countries: 8. Publications: 1.
The Relationship Between Dual-task Gait Performance, Physical Activity Levels, Sleep and Aging in Healthy Adults
ClinicalTrials.gov study NCT04144647. IPD Sharing: NO. Countries: 1. Publications: 27.
BAILA: Being Active, Increasing Latinos Healthy Aging
ClinicalTrials.gov study NCT01988233. IPD Sharing: Not stated. Countries: 1. Publications: 3.
COMPASS 65+ - Community-based Physical Activity Snacks for Healthy Aging in Overweight and Obese Aged Adults
ClinicalTrials.gov study NCT07289529. IPD Sharing: NO. Countries: 1. Publications: 10.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.