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27
datasets available to search
ShareScore release 0.9.0
Dataset results
27 results for “acute phase response”
Data from: Biologging in a free-ranging mammal reveals apparent energetic trade-offs among physiological and behavioral components of the acute phase response
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Data from: Anthelmintic drugs modulate the acute phase immune response but not the microbiota in wild Song Sparrows
<p>Co-infection with microparasites (e.g., bacteria) and macroparasites (e.g., helminths) is often the natural state for wild animals. Despite evidence that gut helminths can bias immune responses away from inflammatory processes, few field studies have examined the role that helminths, or their potential interactions with internal microbial communities, play in modulating immunity in free-living, wild birds. Here, we used anthelmintic drugs to treat wild Song Sparrows (<em>Melospiza melodia</em>) for helminth infections and measured markers of systemic inflammation (heterothermia and locomotor activity) in response to an immune challenge with lipopolysaccharide (LPS), a cell wall component of gram-negative bacteria. Using birds from a population that previously showed high helminth prevalence, we monitored skin temperature and activity remotely using automated radio telemetry. We also collected cloacal swabs to determine whether drug treatment was associated with changes in the cloacal microbiota, and whether cloacal microbial community structure was associated with the severity of birds' immune responses. Because helminths can reduce the severity of inflammatory immune responses in other species, we predicted that in comparison with untreated control birds, anthelmintic-treated birds would be more lethargic and display higher fevers when challenged with LPS. Consistent with these predictions, anthelmintic-treated birds expressed higher fevers in response to immune challenge. However, all LPS-challenged birds decreased locomotor activity to a similar degree, regardless of anthelmintic treatment. Although several individual indicator bacterial taxa were strongly associated with anthelmintic treatment, this treatment did not alter overall bacterial alpha- and beta- diversity. Similarly, we did not find evidence that bacterial community diversity influenced the severity of immune responses to LPS. These results suggest that under field conditions, natural helminth infection can reduce the severity of songbirds' thermoregulatory responses (fever) during an immune challenge, without major impacts on internal microbial communities or behavioral responses to infection.</p>
Data from: Anthelmintic drugs modulate the acute phase immune response but not the microbiota in wild Song Sparrows
Open the record for dataset details and reuse information.
Preoperative Feeding With a Whey Protein Plus Carbohydrate Drink on the Acute Phase Response and Insulin Resistance
ClinicalTrials.gov study NCT01354249. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Acute-phase Response & Periodontal Treatment in Diabetes Affected Patients
ClinicalTrials.gov study NCT03087266. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Disorders of the Acute Phase Response Following Trauma and Invasive Surgery
ClinicalTrials.gov study NCT03741023. IPD Sharing: NO. Countries: 1. Publications: 1.
Pravastatin Reduces Acute Phase Response of Zoledronic Acid
ClinicalTrials.gov study NCT04719481. IPD Sharing: NO. Countries: 0. Publications: 5.
Acute Phase Response & Periodontal Treatment
ClinicalTrials.gov study NCT02460926. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Acute multi-level response to defective de novo chromatin assembly in S-phase
GEO Series GSE262518. Homo sapiens. 72 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
Similarities and differences in the acute-phase response to SARS-CoV-2 in rhesus macaques and African green monkeys
GEO Series GSE184949. Macaca mulatta; Chlorocebus sabaeus. 44 samples. Type: Expression profiling by high throughput sequencing.
XBP1 coregulates unfolded protein response, acute phase response and DNA damage response during mouse liver regeneration
GEO Series GSE86048. Mus musculus. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Changes in cholesterol homeostasis and acute phase response following pulmonary exposure to multi-walled carbon nanotubes links carbon nanotube exposure to risk of cardiovascular disease
GEO Series GSE61366. Mus musculus. 60 samples. Type: Expression profiling by array.
Transcriptome profiling of the hepatic acute-phase response in LPS-treated dHepaRG cells.
GEO Series GSE230325. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Spliceosome mutations are associated with clinical response in a Phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia.
GEO Series GSE239678. Homo sapiens. 35 samples. Type: Expression profiling by high throughput sequencing.
Low-Dose Endotoxemia and the Acute Phase Response
ClinicalTrials.gov study NCT00197899. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Acute-phase Response & Periodontal Treatment in Obese Patients
ClinicalTrials.gov study NCT03122977. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of the Innate Immune Response to the Acute Phase of Human Leptospirosis - IMMUNOLEPTO
ClinicalTrials.gov study NCT05413720. IPD Sharing: NO. Countries: 1. Publications: 0.
Defining the Temporal Changes in the Acute Phase Response During Graded Exercise: A Prospective Study
ClinicalTrials.gov study NCT03398304. IPD Sharing: NO. Countries: 1. Publications: 0.
Isoflavones and Acute-phase Response in Chronic Renal Failure
ClinicalTrials.gov study NCT00029796. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Acute-phase Response & Periodontal Treatment in Patients With Hypertension
ClinicalTrials.gov study NCT03122990. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.