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262 results for “acute stress”
Dataset-Response strategies to acute and chronic environmental stress in the arctic breeding Lapland longspur (Calcarius lapponicus)
<p>This is the dataset presenting the phenotypic measurements in the paper Response strategies to acute and chronic environmental stress in the arctic breeding Lapland longspur (<em>Calcarius lapponicus</em>).</p>
A phenopushing platform to identify compounds that alleviate acute hypoxic stress by fast-tracking cellular adaptation
<p><span>Severe acute hypoxic stress is a major contributor to the pathology of human diseases, including ischemic disorders. Current treatments focus on managing consequences of hypoxia, with few addressing cellular adaptation to low-oxygen environments. Here, we investigate whether accelerating hypoxia adaptation could provide a strategy to alleviate acute hypoxic stress. We develop a high-content phenotypic screening platform to identify compounds that fast-track adaptation to hypoxic stress. </span><span>Our platform</span><span> captures a high-dimensional phenotypic hypoxia response trajectory consisting of normoxic, acutely stressed, and chronically adapted cell states. Leveraging this trajectory, we identify compounds that phenotypically shift cells from the acutely stressed towards the adapted state, revealing mTOR/PI3K or BET inhibition as strategies to induce this phenotypic shift. Importantly, </span><span>our</span><span> compound hits promote the survival of liver cells exposed to ischemia-like stress, and rescue cardiomyocytes from hypoxic stress. Our “phenopushing” platform offers a general, target-agnostic approach to identify compounds and targets that accelerate cellular adaptation, applicable across various stress conditions.</span></p>
Acute stress and restricted diet reduce bill-mediated heat dissipation in the song sparrow (Melospiza melodia): Implications for optimal thermoregulation
<p>We used thermal imaging to show that two environmental factors—acute stress and diet—influence thermoregulatory performance of a known thermal window, the avian bill. The bill plays important roles in thermoregulation and water balance. Given that heat loss through the bill is adjustable through vasoconstriction and vasodilation, and acute stress can cause vasoconstriction in peripheral body surfaces, we hypothesized that stress may influence the bill's role as a thermal window. We further hypothesized that diet influences heat dissipation from the bill given that body condition influences the surface temperature of another body region (the eye region). We measured the surface temperature of the bills of song sparrows (<em>Melospiza</em> <em>melodia</em>) before, during, and after handling by an observer at 37°C ambient temperature. We fed five birds a restricted diet intended to maintain bodyweights typical of wild birds, and we fed six birds an unrestricted diet for five months prior to experiments. Acute stress caused a decrease in the surface temperature of the bill, resulting in a 32.4% decrease in heat dissipation immediately following acute stress, before recovering over approximately 2.3 minutes. The initial reduction and subsequent recovery provide partial support for the haemoprotective and thermoprotective hypotheses, which predict a reduction or increase in peripheral blood flow, respectively. Birds with unrestricted diets had larger bills and dissipated more heat, indicating that diet and body condition influence bill-mediated heat dissipation and thermoregulation. These results indicate that stress-induced vascular changes and diet can influence mechanisms of heat loss and potentially inhibit optimal thermoregulation.</p>
Cranial Electrotherapy Stimulation and Acute Stress
ClinicalTrials.gov study NCT06034496. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Differences in gene expression between high and low tolerance rainbow trout (Oncorhynchus mykiss) to acute thermal stress
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Acute stress and restricted diet reduce bill-mediated heat dissipation in the song sparrow (Melospiza melodia): Implications for optimal thermoregulation
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Cellular and whole‐organism effects of prolonged versus acute heat stress in a montane, desert lizard
<p>Global climate change involves both prolonged periods of higher-than-normal temperatures, and short but extreme heat waves. Both types of temperature increases are likely to be detrimental to ectotherms, and even if such temperature increases do not cause mortality directly, compensating for such temperature increases will likely entail costs to organisms. We tested the effects of prolonged periods of higher-than-average temperatures and short-term, acute heat stress in wild populations of greater short-horned lizards (<i>Phrynosoma hernandesi</i>), a temperate, montane lizard of the Colorado Plateau, U.S.A. We transplanted one group of lizards from a high- to a low-elevation site, exposing them to a prolonged period of warmer temperatures. These lizards, exposed to prolonged periods of higher-than-average temperatures, experienced no change in sprint speed, endurance, or heat shock protein production after treatment compared to baseline levels; however, they had lower water content after the transplant to a warmer climate compared to before the transplant. We exposed a second group of lizards to acute heat stress by exposing them to thermally stressful temperatures for four hours. These lizards, exposed to a short period of acute heat stress, had no change in endurance, water content, or heat shock protein production following acute heat stress; however, lizards exposed to acute heat stress had slower sprint speeds than control lizards. Our results demonstrate that both prolonged temperature increases and acute heat stress, each of which are predicted to occur with climate change, had different cellular and/or whole organismal-level effects on lizards.</p>
Network analysis reveals that acute stress exacerbates gene regulatory responses of the gill to seawater in Atlantic salmon
<p>The transition from freshwater to seawater represents a physiological challenge for Atlantic salmon smolts preparing for downstream migration. Stressors occurring during downstream migration to the ocean impair the ability of smolts to maintain osmotic/ionic homeostasis in seawater. The molecular mechanisms underlying this interaction are not fully understood, especially at the organ level. We combined RNA-Seq with measures of whole-animal homeostasis to examine gene expression dynamics in the gills of smolts associated with impaired seawater tolerance after an aquaculture-related stressor. Smolts were given a 24 h seawater tolerance test before and after exposure to an acute handling/confinement stress. RNA-Seq followed by differential expression and weighted gene correlation network analysis (WGCNA) was used to quantify the transcriptional response of the gill to handling/confinement stress, seawater and their interaction. Exposure to acute stress was associated with a general stress response and impaired osmotic/ionic homeostasis in seawater. We identified gene networks in the gill exhibiting response to acute stress alone, seawater alone, and others exhibiting combined effects of both stress and seawater. Our findings indicate that acute handling/ confinement stress increases the intensity of seawater-related gene expression and suggest that increased investment in mechanisms related to ion transport may be part of a compensatory response to impaired seawater tolerance in smolts.</p>
Obesity and acute stress modulate appetite and neural responses in food word reactivity task
<p>Data used in "Carnell S, Benson L, Papantoni A, Chen L, Huo Y, Wang Z, Peterson BS, Geliebter A. Obesity and acute stress modulate appetite and neural responses in food word reactivity task. PloS one"</p>
Additional raw video and pose estimation data of top view mouse behavior recordings (marble burying test, light-dark box, fear conditioning box) of acute and chronic stress models
<p>This repository contains raw data for 296 different behavioral recordings of mice (marble burying test, light-dark box, fear conditioning box). These include top view raw video .mp4 files (Videos.zip) and the corresponding .csv pose estimation data (data.zip) obtained with DeepLabCut. The data is from multiple different experiments. The METADATA.csv or METADATA.xlsx files contain all grouping variables and help linking the pose estimation files (located in multiple subfolders of /data) to the video files. Visit https://github.com/ETHZ-INS/BehaviorFlow to find out more about how this data has be used by us.</p>
Raw video and pose estimation data of top view open field mouse behavior recordings of acute and chronic stress models
<p>This repository contains raw data for 411 different open field recordings of mice. these include top view raw video .mp4 files (Videos.zip) and the corresponding .csv pose estimation data (data.zip) obtained with DeepLabCut. The data is from multiple different experiments. The METADATA.csv or METADATA.xlsx files contain all grouping variables and help linking the pose estimation files (located in multiple subfolders of /data) to the video files. Visit https://github.com/ETHZ-INS/BehaviorFlow to find out more about how this data has be used by us.</p>
Explorative Efficacy Profile of Neurexan® in an Experimental Acute Stress Setting in Healthy Subjects
ClinicalTrials.gov study NCT01703819. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Explorative Open Label Study of Efficacy Profile of Neurexan® in Experimental Acute Stress Setting in Healthy Subjects
ClinicalTrials.gov study NCT01703832. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Data from: Early molecular oxidative stress biomarkers of ischemic penumbra in acute stroke
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Data from: Oxygen supersaturation could protect reef-building corals against acute thermal stress
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Network analysis reveals that acute stress exacerbates gene regulatory responses of the gill to seawater in Atlantic salmon
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Data for: Local environments, not hybridization, influence cardiac performance of native trout under acute thermal stress
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Cellular and whole‐organism effects of prolonged versus acute heat stress in a montane, desert lizard
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Data from: The lingering impact of stress: brief acute glucocorticoid exposure has sustained, dose-dependent effects on reproduction
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Data from: Stressed connections: cortisol levels following acute psychosocial stress disrupt affiliative mimicry in humans
Mimicry, and especially spontaneous facial mimicry, is a rudimentary element of social–emotional experience that is well-conserved across numerous species. Although such mimicry is thought to be a relatively automatic process, research indicates that contextual factors can influence mimicry, especially in humans. Here, we extend this work by investigating the effect of acute psychosocial stress on spontaneous facial mimicry. Participants performed a spontaneous facial mimicry task with facial electromyography (fEMG) at baseline and approximately one month later, following an acute psychosocial stressor (Trier Social Stress Test). Results show that the magnitude of the endocrine stress response reduced zygomaticus major reactivity, and specifically spontaneous facial mimicry for positive social stimuli (i.e. smiles). Individuals with higher levels of the stress hormone cortisol showed a more blunted fEMG response to smiles, but not to frowns. Conversely, stress had no effect on corrugator supercilii activation (i.e. frowning to frowns). These findings highlight the importance of the biological stress response system in this basic element of social–emotional experience.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.