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Dataset results
17 results for “adhesin”
Ectopical expression of bacterial collagen-like protein supports its role as adhesin in host-parasite coevolution
<div> <div> <div> <div> <p>For a profound understanding of antagonistic coevolution, it is necessary to identify the coevolving genes. The bacterium Pasteuria and its host, the microcrustacean Daphnia, are a well-characterized paradigm for co-evolution, but the underlying genes remain largely unknown. A genome-wide association study suggested a Pasteuria collagen-like protein 7 (Pcl7) as a candidate mediating parasite attachment and driving its coevolution with the host. Since Pasteuria ramosa cannot currently be genetically manipulated, we used Bacillus thuringiensis to express a fusion protein of a Pcl7 carboxy- terminus from P. ramosa and the amino-terminal domain of a B. thuringiensis collagen-like protein (CLP). Mutant B. thuringiensis (Pcl7-Bt) spores but not wild-type B. thuringiensis (WT-Bt) spores, attached to the same site of susceptible hosts as P. ramosa. Furthermore, Pcl7-Bt spores attached readily to susceptible host genotypes, but only slightly to resistant host genotypes. These findings indicated that the fusion protein was properly expressed and folded and demonstrated that indeed the C-terminus of Pcl7 mediates attachment in a host genotype-specific manner. These results provide strong evidence for the involvement of a CLP in the coevolution of Daphnia and P. ramosa and open new avenues for genetic epidemiological studies of host–parasite interactions.</p> </div> </div> </div> </div>
Computational Data for Weaker interdomain interactions in FimH30 from multidrug-resistant Escherichia coli ST131 mediate longer lasting interactions with mannose and enhanced adhesin function
<p>Input files for the MD simulations and the resulting trajectories. A representative trajectory is provided for the R and T state of each allele. </p>
Ectopical expression of bacterial collagen-like protein supports its role as adhesin in host-parasite coevolution
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Peptide-based ligand antagonists block a <em>Vibrio cholerae</em> adhesin
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Variation at an adhesin locus suggests sociality in natural populations of the yeast Saccharomyces cerevisiae
<p>Microbes engage in numerous social behaviors that are critical for survival and reproduction, and that require individuals to act as a collective. Various mechanisms ensure that collectives are composed of related, cooperating cells, thus allowing for the evolution and stability of these traits, and for selection to favor traits beneficial to the collective. Since microbes are difficult to observe directly, sociality in natural populations can instead be investigated using evolutionary genetic signatures, as social loci can be evolutionary hotspots. The budding yeast has been studied for over a century, yet little is known about its social behavior in nature. Flo11 is a highly regulated cell adhesin required for most lab social phenotypes; studies suggest it may function in cell recognition and its heterogenous expression may be adaptive for collectives such as biofilms. We investigated this locus and found positive selection in the areas implicated in cell-cell interaction, suggesting selection for kin discrimination. We also found balancing selection at an upstream activation site, suggesting selection on the level of variegated gene expression. Our results suggest this model yeast is surprisingly social in natural environments and is likely engaging in various forms of sociality. By utilizing genomic data, this research provides a glimpse of otherwise unobservable interactions.</p>
Optimal Sacrificial Domains in Mechanical Polyproteins: S. epidermidis Adhesins Are Tuned for Work Dissipation
<p>Data underlying the figures in the publication: Liu, H. <em>et al</em>. “Optimal Sacrificial Domains in Mechanical Polyproteins: <em>S. epidermidis</em> Adhesins Are Tuned for Work Dissipation” <em>JACS Au</em> <strong>2022</strong> <em>2</em>, 1417-1427, <a href="https://doi.org/10.1021/jacsau.2c00121">https://doi.org/10.1021/jacsau.2c00121</a></p>
Challenge of the Nasopharynx With Neisseria Lactamica Expressing the Meningococcal Protein Neisseria Adhesin A (NadA)
ClinicalTrials.gov study NCT03630250. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Variation at an adhesin locus suggests sociality in natural populations of the yeast Saccharomyces cerevisiae
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Data from: Single-molecule imaging and quantification of the immune-variant adhesin VAR2CSA on knobs of Plasmodium falciparum-infected erythrocytes
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Transcriptomic analysis of Streptococcus pyogenescolonizing the vaginal mucosa identifies hupY, an MtsR-regulated adhesin involved in heme utilization
GEO Series GSE131982. Streptococcus pyogenes. 6 samples. Type: Expression profiling by high throughput sequencing.
Colibactin-driven colon cancer requires adhesin-mediated epithelial binding
GEO Series GSE241851. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
Expression of Adhesive Pili and the Collagen-Binding Adhesin Ace Is Activated by ArgR Family Transcription Factors in Enterococcus faecalis.
GEO Series GSE112936. Enterococcus faecalis. 12 samples. Type: Expression profiling by high throughput sequencing.
TosR-mediated regulation of adhesins and biofilm formation in uropathogenic Escherichia coli
GEO Series GSE112878. Escherichia coli. 6 samples. Type: Expression profiling by high throughput sequencing.
The Hyphal Associated Adhesin and Invasin Als3 of Candida albicans Mediates Iron Acquisition from Host Ferritin
GEO Series GSE11490. Candida albicans. 3 samples. Type: Expression profiling by array.
The protein kinase Tor1 regulates adhesin expression in Candida albicans
GEO Series GSE13176. Candida albicans. 12 samples. Type: Expression profiling by array.
A mucin-regulated adhesin determines the spatial organization and inflammatory character of a bacterial symbiont in the vertebrate gut
GEO Series GSE236092. Aeromonas sp. ZOR0001. 11 samples. Type: Expression profiling by high throughput sequencing.
The adhesin RadD enhances Fusobacterium nucleatum tumor colonization and colorectal carcinogenesis
GEO Series GSE245617. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.