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82 results for “administrative data”
Data from: Chronic Rapamycin administration via drinking water mitigates the pathological phenotype in a Krabbe disease mouse model through autophagy activation.
<p>ABSTRACT </p><p>Krabbe disease (KD) is a rare disorder caused by a deficiency of the lysosomal enzyme galactosylceramidase (GALC), resulting in the accumulation of the cytotoxic metabolite psychosine (PSY) in the nervous system. This accumulation triggers demyelination and neurodegeneration. Despite ongoing research, the underlying pathogenic mechanisms remain incompletely understood, and there is currently no cure available.</p><p>Previous studies from our lab revealed the presence of autophagy dysfunctions in KD pathogenesis, as evidenced by the presence of p62-tagged protein aggregates in the brains of KD mice and increased p62 levels in the KD sciatic nerve. We also demonstrated that the autophagy inducer Rapamycin (RAPA) can partially restore the wild-type (WT) phenotype in KD primary cells by reducing the number of p62 aggregates.</p><p>In this study, we tested RAPA in the Twitcher (TWI) mouse, a spontaneous KD mouse model. We administered the drug ad libitum via drinking water (15 mg/L) starting from post-natal day (PND) 21-23. We longitudinally monitored the motor performance of the mice through grip strength and rotarod tests, along with various biochemical parameters related to KD pathogenesis (i.e. autophagy markers expression, myelination, astrogliosis, and PSY accumulation).</p><p>Our findings demonstrate that RAPA significantly enhances motor functions at specific treatment time points and reduces astrogliosis in TWI brain, spinal cord, and sciatic nerves. Using western blot and immunohistochemistry, we observed a decrease in p62 aggregates in TWI nervous tissues, which corroborates our earlier in-vitro results. Furthermore, RAPA treatment partially reduces PSY levels in the spinal cord.</p><p>In conclusion, our results support the consideration of RAPA as a supportive therapy for KD. Importantly, as RAPA is already available in pharmaceutical formulations for clinical use, its potential for KD treatment can be promptly evaluated in clinical trials.</p>
Data: multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes
<p>This data set includes multispectral optoacoustic tomography images supporting an article on cell tracking (preprint: bioRxiv 199836; https://doi.org/10.1101/199836). The corresponding bioluminescence results are included too, as well as the spectra used for the multispectral processing. </p>
Experiment data in support of "Segmentation analysis and the recovery of queuing parameters via the Wasserstein distance: a study of administrative data for patients with chronic obstructive pulmonary disease"
<p>This archive contains a ZIP archive, `data.zip`, that itself contains the data used in the final sections of the paper. The remainder of the paper's supporting files are available at <a href="https://github.com/daffidwilde/copd-paper/">github.com/daffidwilde/copd-paper/</a></p> <p>The ZIP archive is structured as follows:</p> <ul> <li>There is a directory, `wasserstein`, for the parameter sweep described in the model construction section of the paper. Its contents are: (i) a file, `main.csv`, describing each parameter and their maximal Wasserstein distance to the observed data, and (ii) three directories, `best`, `median` and `worst`, each containing the simulated queuing results (in `main.csv`) from that sweep with the best, median and worst found parameter sets, respectively (in `params.txt`).</li> <li>The remaining three directories correspond to the experiments conducted in the final section of the paper. Each directory contains two files: (i) `system_times.csv` which holds trial parameters and system time records for every patient to pass through the model in that experiment, and (ii) `utilisations.csv` which holds trial parameters and utilisations for each server in the model for that experiment.</li> </ul>
France under German occupation. The German and French administration 1940-1945 – full data
<p>At <a href="http://www.adresses-france-occupee.fr">www.adresses-france-occupee.fr</a>, the GHIP provides an interactive map showing the German and French authorities in France during the German occupation of France between 1940 and 1945. In addition to the historical and current address, the website provides information about the tasks, responsibilities and the structure of each department of the authorities, as well as photos if available. Depending on the type and scope of the query, it gives an impression of everyday life, the presence of the German occupation administration and forces and, last but not least, their cooperation with the French authorities. The information is based on a systematic evaluation of the telephone books of the German authorities and French administration directories from the time of the war. They were completed by research in German and French archives, in particular the <em>Archives municipales</em>, as well as press media, historical map collections and research works.</p> <p>With this entry we give access to the data of this database in four different tables (csv UTF-8 and excel).</p> <p>1) The table "services" relates to the departments (German: <em>Dienststellen</em>). The data is maintained in the state closest to that of the phone directories and address books: a department is valid in a hierarchy at a given address and at a given time. The table contains:</p> <p>· the ID number (id), its linking to its superior department (parent_service_id)</p> <p>· the name of the department (name),</p> <p>· the ID number of the source from which the information originates (source_id),</p> <p>· the ID number of the place where the departments office is located (place_id),</p> <p>· the status on the website (status: visible, pending, deleted),</p> <p>· the display of the hierarchy (d_breadcrumb) and</p> <p>· the last edit of the entry by the project team (last_edit_date).</p> <p>There are 68,044 entries in total.</p> <p> </p> <p>2) The table "service_bridge" is a cross table, relating the departments to each other by showing their hierarchy. IT contains the parent_service_id, the child_service_id, and the breadcrumb, that indicates the department's position in the hierarchy. There are 28,162 entries in total</p> <p> </p> <p>3) The table "places" is used to localise the departments. A place is a geographical point identified by its latitude and longitude. The address (in text format) of this place may have changed over time. The database contains both old and new names. The table contains the ID number of the place (id), the name of the building/accommodation (name), the status of the entry on the website (status: visible, pending, deleted), the current address (current_country, current_zip, current_city, current_street, current_house_number), former address (fromer_street, former_house_number) as well as the longitude and latitude of the place. There are 15,454 entries in total.</p> <p> </p> <p>4) The table "sources_details" relates to the sources used to build the database. By source we understand ‘data source’, i.e. any source used to obtain information on the German and French authorities of the time. We mostly used German and French telephone directories of the years 1940–1944. The table contains:</p> <p>· the ID number of the source (id),</p> <p>· the name of the source in short (name),</p> <p>· the country of publication or origin of the source (country),</p> <p>· the full edition date (edition_date) if available, otherwise approximate,</p> <p>· the year of the publication or year of the source (d_edition_year),</p> <p>· the month of the publication or month of the source (d_edition_month) and</p> <p>· the full bibliographical citation and/or explanations (source_name_complete).</p> <p>There are 57 entries in total.</p> <p>You can get in touch with us via the mail dh [at] dhi-paris.fr</p>
Data on the administrative workload and perceived administrative burden of farmers in Switzerland
<table> <tbody> <tr> <td> <p>We present data from a paper-and-pencil survey of Swiss farmers. The survey was mailed to 2,000 randomly selected Swiss farmers from the two largest Swiss language regions (German and French) in February 2019. A reminder was sent in April 2019. The response rate was around 40% (N = 808). In the main part of the survey, we collected quantitative data on farmers’ workload and perceived burden due to (1) overall farming activities, (2) administrative activities related to the application of direct payments, and (3) other office work related to farm planning, bookkeeping, purchasing, and sales. We also asked farmers to rate their current workload and perceived administrative burden compared to five years earlier. We also collected data on the perceived burden of using e-government services, the administrative workload of various voluntary direct payment schemes, and the workload of inspections and sanctions. We collected personal information about the farmers, such as age, education, work experience on the farm, work outside the farm, and their political activities (e.g. as a board or executive member in political or agricultural organisations). Finally, the farmers were asked to rate a series of statements regarding agricultural policy measures, the importance of inspection measures, the obligation to provide proof of eligibility for direct payments, information on current policy measures, and the justification of penalties for non-compliance with environmental or animal welfare standards. The survey results showed that, on average, Swiss farmers spent 3–5% of their total working time on administrative tasks. Based on a 60-hour working week, this means that, on average, farmers spent about 1.8–3 hours per working week on administrative activities. The farmers rated the perceived burden of administrative activities as higher than the burden of overall farming activities or other office work. The results also showed that the time spent on administrative activities and the associated perceived administrative burden had increased compared to five years earlier. Finally, the results showed that 28% of the Swiss farmers had received a penalty for non-compliance with direct payment regulations.</p> <p> </p> </td> </tr> </tbody> </table>
Data release: Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
<p>Source data used in the publication: Berger et al. (2021) - Provisional title: 'Whole-genome sequencing of <em>Schistosoma mansoni</em> reveals extensive diversity with limited selection despite mass drug administration'. These data were used to generate all figures used in the publication and all files are organised and labelled specifically to run with the custom code that uses these data can be found at: http://doi.org/10.5281/zenodo.4975908. </p> <p><br> <strong>File descriptions:</strong></p> <p><strong>SOURCE DATA.zip - All source data for all figures. </strong></p> <p><strong>Figure 1b:</strong></p> <ul> <li>supplementary_data_9.txt - Metadata</li> </ul> <p><strong>Figure 2a&b:</strong></p> <ul> <li>207_PCA.eigenvec - PCA eigenvectors</li> <li>207_PCA.eigenval - PCA eigenvalues</li> </ul> <p><strong>Figure 2c:</strong></p> <ul> <li>autosomes.mdist - PLINK distance matrix used to build the neighbour joining phylogeny</li> </ul> <p><strong>Figure 2d:</strong></p> <ul> <li>all.pi.pixy.schools.txt - Nucleotide diversity results for each school subpopulation.</li> </ul> <p><strong>Figure 2e:</strong></p> <ul> <li>autosomes.dxy.5kb.schools.txt - Autosomal D<sub>XY</sub> results between school subpopulations. </li> <li>autosomes.fst.5kb.schools.txt - Autosomal F<sub>ST</sub> results between school subpopulations.</li> </ul> <p><strong>Figure 2f:</strong></p> <ul> <li>admixture_all.txt - ADMIXTURE results for each sample and population sizes, column 1 represents number of populations (K), columns 3-8 represent admixture values for each population. </li> </ul> <p><strong>Figure 3a, Supplementary figure 10a:</strong></p> <ul> <li>sfs.csv - Site frequency spectra (allelic proportions at each frequency bin) for each school. </li> </ul> <p><strong>Figure 3b:</strong></p> <ul> <li>TD.all.txt - Tajima's D values calculated in 5 kb windows for each school subpopulation. </li> </ul> <p><strong>Figure 4a, Supplementary figures 13-18: </strong></p> <ul> <li>ALL.MAYUGE.IHS.ihs.out.100bins.norm.txt.zip - Normalised iHS scores for the Mayuge district parasite populations (Selscan output).</li> </ul> <p><strong>Figure 4b, Supplementary figures 13-18: </strong></p> <ul> <li>ALL.TORORO.IHS.ihs.out.100bins.norm.txt.zip -<strong> - </strong>Normalised iHS scores for the Tororo district parasite populations (Selscan output).</li> </ul> <p><strong>Figure 4c, Supplementary figures 13-18: </strong></p> <ul> <li>ALL.MAYUGEvsTORORO.xpehh.xpehh.out.norm.txt.zip - - Normalised XP-EHH scores between Mayuge and Tororo parasite populations.</li> </ul> <p><strong>Figure 4d, Supplementary figures 13-18:</strong></p> <ul> <li>MAYUGE_TORORO_2000.windowed.weir.txt.zip - F<sub>ST</sub> values calculated between Mayuge and Tororo populations in 2kb windows. </li> </ul> <p><strong>Figure 4e, Supplementary figures 12a&c:</strong></p> <ul> <li>MAYUGE_PI.windowed.pi.zip - Nucleotide diversity values calculated in 2 kb windows for Mayuge populations. </li> <li>TORORO_PI.windowed.pi.zip - Nucleotide diversity values calculated in 2 kb windows for Kocoge populations (Tororo district).</li> </ul> <p><strong>Figure 5a:</strong></p> <ul> <li>all.pi.treat.fix.txt.zip - Nucleotide diversity results for each treatment subpopulation</li> </ul> <p><strong>Figure 5b</strong></p> <ul> <li>autosomes.dxy.5kb.treatment.txt - <strong> </strong>- Autosomal D<sub>XY</sub> results between clearance phenotype subpopulations. </li> <li>autosomes.fst.5kb.treatment.txt<strong> </strong>- Autosomal F<sub>ST</sub> results between clearance phenotype subpopulations. </li> </ul> <p><strong>Figure 5c:</strong></p> <ul> <li>fst.windows.2kb.treatment.txt.zip - F<sub>ST</sub> values for comparisons between different treatment groups (Pre-treatment, post-treatment (good clearers), post-treatment (poor clearers))</li> </ul> <p><strong>Figure 5d: </strong></p> <ul> <li>assoc_err_binary.txt.zip - Results of binary trait association between miracidia sampled from hosts with good clearance phenotypes (where treatment appeared to be highly effective) and miracidia isolated post-treatment from hosts with poor clearance phenotypes (where miracidia are potentially derived from parasites that survived treatment.</li> </ul> <p><strong>Figure 5e:</strong></p> <ul> <li>assoc_err_linear.txt.zip - - Results of linear regression genome-wide association study with the ERR estimates for all 198 samples, using the mean of the posterior ERR estimates from Crellen et al. (2016) as a quantitative trait.</li> </ul> <p><strong>Supplementary figure 1:</strong></p> <ul> <li>median.coverage.txt - Normalised depth of read coverage (column 4) calculated in 25 kb windows (columns 2&3) across all samples for all chromosomes (column 1).</li> </ul> <p><strong>Supplementary figure 2a-f: </strong></p> <ul> <li>cohort.genotyped.txt.zip - <strong> </strong>- Variant quality site values (used to inform variant site retention or removal). </li> </ul> <p><strong>Supplementary figure 2g:</strong></p> <ul> <li>hard_filtered.imiss.txt - Per sample variant missingness (used to inform quality control).</li> </ul> <p><strong>Supplementary figure 2h:</strong></p> <ul> <li>hard_filtered_filtindv.lmiss.txt.zip - Per site missingness (used to inform quality control).</li> </ul> <p><strong>Supplementary figure 3a, 4a, 4b:</strong></p> <ul> <li>prunedData.eigenvec - PCA eigenvectors</li> <li>prunedData.eigenval - PCA eigenvalues</li> </ul> <p><strong>Supplementary figure 3b:</strong></p> <ul> <li>pruned_data.mdist.csv - Distance matrix used as the basis for the neighbour joining phylogeny.</li> </ul> <p><strong>Supplementary figure 5:</strong></p> <ul> <li>cv_scores.txt - ADMIXTURE coefficient of variation scores (column 2) for each population size (1).</li> </ul> <p><strong>Supplementary figure 6:</strong></p> <ul> <li>*_SMC_SE.csv - SMC++ results (from 25 subsampled replicates) for each school subpopulation and outgroup samples. </li> </ul> <p><strong>Supplementary Figure 7:</strong></p> <ul> <li>smcpp.csv - SMC++ results for each school subpopulation and outgroup samples. </li> </ul> <p><strong>Supplementary Figure 8a-d</strong></p> <ul> <li>pi.per_host.txt.zip - Nucleotide diversity values for each host infrapopulation. </li> </ul> <p><strong>Supplementary Figure 9:</strong></p> <ul> <li>sexing.csv - inferred sex (based on differential read coverage over pseudoautosomal and Z-specific regions of the Z chromosome). </li> </ul> <p><strong>Supplementary Figure 10b:</strong></p> <ul> <li>sfs_res.csv - residuals for the SFS analysis in 3a/10a.</li> </ul> <p><strong>Supplementary Figure 11:</strong></p> <ul> <li>MAYUGE_TAJIMA_D.Tajima.D.2kb.txt.zip - Tajima's D values calculated for the Mayuge population in 2kb windows. </li> <li>Tororo_TAJIMA_D.Tajima.D.2kb.txt.zip - Tajima's D values calculated for the Tororo population in 2kb windows. </li> </ul> <p><strong>Supplementary Figures 13-18:</strong></p> <ul> <li>genes.bed - Coordinates of gene models (<em>S. mansoni </em>v7 annotation).</li> <li>KOCOGE_SITE_PI.sites.pi.txt.zip - Per site nucleotide diversity values</li> <li>MAYUGE_TORORO_sites.weir.fst.txt.zip - Per site F<sub>ST</sub> values between Mayuge and Tororo populations. </li> <li>coverage_5kb.windows.txt.zip - Per sample depth of read coverage in 5 kb windows. Columns 4,5,6 represent the median, mean and sstev of coverage for each 5kb window (columns 2&3) along each chromosome (column 1). </li> <li>median.sample.coverage.txt - Median chromosomal depth of read coverage for each sample. </li> </ul> <p><strong>Supplementary Figure 19:</strong></p> <ul> <li>kocoge_median.ld.txt.zip - <strong> </strong>- The decay of linkage disequilibrium with genomic distance between all sites within 50 kb for the Kocoge parasite samples. Chromosomes are shown in column 1, distance in column 2, median values in column 3. </li> <li>mayuge_median.ld.txt.zip - The decay of linkage disequilibrium with genomic distance between all sites within 50 kb for the Mayuge parasite samples. Chromosomes are shown in column 1, distance in column 2, median values in column 3. </li> </ul> <p><strong>Misc files:</strong></p> <p>schools.list - List of samples and schools where they were sampled. </p> <p> </p>
Data from: Intranasal administration of dantrolene increased brain concentration and duration
<p>Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent. Here, we studied whether the intranasal administration of dantrolene provided better penetration into the brain than the commonly used oral approach. C57BL/6<b> </b>mice, aged 2-4 months, received a single dose of either intranasal or oral dantrolene (5mg/kg). Inhibition of dantrolene clearance from the brain was examined by co-administration with P-gp/BCRP inhibitors, nimodipine or elacridar. The concentration of dantrolene in the brain and plasma was measured at 10, 20, 30, 50, 70, 120, 150 and 180 minutes after administration. Separate cohorts of mice were given intranasal dantrolene (5mg/kg) or vehicle, 3 times/ week, for either 3 weeks or 4 months, to examine potential adverse side effects on olfaction and motor coordination, respectively.</p> <p>We found that Dantrolene concentrations were sustained in the brain after intranasal administration for 180 min, while concentrations fell to zero at 120 min for oral administration. <span>Chronic use of intranasal dantrolene did not impair olfaction or motor function in these mice. Blood brain barrier pump inhibitors</span> did not further increase dantrolene peak concentrations in the brain. Our results suggested that<i> </i>Intranasal administration of dantrolene is an effective route to increase its concentration and duration in the brain compared to the oral approach, without any obvious side effects on olfaction or motor function.</p>
DigitalHabsburgPlatform/example-data: DHP I administration data, incl. institutions
<p>Re-release with institutions from MPR</p>
Data from: Genetic analysis of red deer (Cervus elaphus) administrative management units in a human-dominated landscape - patterns of genetic diversity, population structure and gene flow
<p><span><span>Red deer (</span><span><em>Cervus elaphus</em></span><span>) throughout central Europe are</span> impacted by different anthropogenic activities including habitat fragmentation, selective hunting, and translocations<span>. This has substantial influences on genetic diversity and the long-term conservation of local populations of this species. Here we use genetic samples from 480 red deer individuals to assess the genetic diversity and differentiation of the 12 administrative management units located in Schleswig Holstein, the northernmost federal state in Germany. </span></span><span><span>We applied multiple analytical approaches and show that the history of local populations (i.e., translocations, culling of individuals outside of designated red deer zones, and anthropogenic infrastructures) has led to comparably low levels of genetic diversity. The mean expected heterozygosity was below 0.6 and we observed on average 4.2 alleles across 12 microsatellite loci. Effective population sizes below the recommended level of 50 were estimated for multiple local populations. </span></span><span><span>Our estimates of genetic structure and gene flow show that red deer in northern Germany are best described as a complex network of asymmetrically connected subpopulations, with high genetic exchange among some local populations and reduced connectivity of others. Genetic diversity was also correlated with population densities of neighboring management units. </span></span></p> <p><span><span>Based on these findings, we suggest that connectivity among existing management units needs to be considered in the practical management of the species, which means that some administrative management units should be managed together, while the effective isolation of other units needs to be mitigated.</span></span></p>
Ensemble and single cell data for primary Ovis Aries pulmonary artery endothelial cells response to IGF-1 administration
<p>Data for IGF-1 administration of healthy and persistent pulmonary hypertension of the newborn primary Ovis Aries pulmonary artery endothelial cells.</p> <p>Ensemble.zip:<br> Dose-response to IGF-1<br> Proliferation<br> Western blots for VEGF and eNOS<br> IGF-1R and mTOR inhibition<br> Branch points in tube formation assay<br> <br> IF.zip:<br> Cellprofiler 3.1 analysis of snapshot data for the time course of IGF-1 administration with nuclei, actin, VEGF, and eNOS</p> <p>Translation.zip:<br> CellProfiler 3.1 analysis of snapshot data for the time course of IGF-1 administration with nuclei and total protein production</p>
Replication Data for: Diversidade de Gênero nos Conselhos de Administração e sua Relação com Desempenho e Risco Financeiro nas Empresas Familiares. Published by Journal of Contemporary Administration, 23(6), 2019.
<p>This paper analyzes the influence of female participation on the performance and financial risk considering a sample of 218 public companies traded on B3 (Bovespa) from 2010 a 2016. The study also analyzes the influence of female participation on family control companies. Using a random effects methodology and family control dummy and percentage of female presence in boards of director, the study sought to analyze how theses variables and their interactions affect the financial performance of companies. Although the female representation has grown more than 50% in recent years, this share, however, in the board of directors of Brazilian companies is still a minority, close to 9% of the total surveyed. The ownership structure in the family firms is very relevant, with the percentage of 63%. The results suggest a positive relation between female participation and the Tobin-Q, used by value’s proxy, however, this relationship is weaker for firms with a family control. Another result found is that volatility, taken here as a risk’s proxy, is reduced in family run-business.</p>
Data from: Postnatal administration of S-adenosylmethionine restores developmental AHR activation-induced deficits in CD8+ T cell function during influenza A virus infection
<p>Abstract Developmental exposures can influence life-long health; yet, counteracting negative consequences is challenging due to poor understanding of cellular mechanisms. The aryl hydrocarbon receptor (AHR) binds many small molecules, including numerous pollutants. Developmental exposure to the signature environmental AHR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) significantly dampens adaptive immune responses to influenza A virus (IAV) in adult offspring. CD8+ cytotoxic T lymphocytes (CTL) are crucial for successful infection resolution, which depends on the number generated and the complexity of their functionality. Prior studies showed developmental AHR activation significantly reduced the number of virus-specific CD8+ T cells, but impact on their functions is less clear. Other studies showed developmental exposure was associated with differences in DNA methylation in CD8+ T cells. Yet, empirical evidence that differences in DNA methylation are causally related to altered CD8+ T cell function is lacking. The two objectives were to ascertain whether developmental AHR activation affects CTL function, and whether differences in methylation contribute to reduced CD8+ T cell responses to infection. Developmental AHR triggering significantly reduced CTL polyfunctionality, and modified the transcriptional program of CD8+ T cells. S-adenosylmethionine (SAM), which increases DNA methylation, but not Zebularine, which diminishes DNA methylation, restored polyfunctionality and boosted the number of virus-specific CD8+ T cells. These findings suggest that diminished methylation, initiated by developmental exposure to an AHR-binding chemical, contributes to durable changes in antiviral CD8+ CTL functions later in life. Thus, deleterious consequence of development exposure to environmental chemicals are not permanently fixed, opening the door for interventional strategies to improve health.</p>
Safety and Effectiveness of Apixaban in Very Elderly Patients With Non-valvular Atrial Fibrillation (NVAF) Compared to Warfarin Using Administrative Claims Data
ClinicalTrials.gov study NCT05438888. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Postnatal administration of S-adenosylmethionine restores developmental AHR activation-induced deficits in CD8+ T cell function during influenza A virus infection
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Data from: Genetic analysis of red deer (Cervus elaphus) administrative management units in a human-dominated landscape - patterns of genetic diversity, population structure and gene flow
Open the record for dataset details and reuse information.
Demographic data, reporting guidelines underlying the manuscript: The effect of morning versus evening administration of Empagliflozin on its pharmacokinetics and pharmacodynamics characteristics in healthy adults: a two way cross over, non-randomized trial
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Data from: Intranasal administration of dantrolene increased brain concentration and duration
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Dump of metadata from the Czech National Open Data Catalog, 2020-04-20, State Administration of Land Surveying and Cadastre datasets removed
<p>Dump of metadata using DCAT-AP from the Czech National Open Data Catalog, 2020-04-20, in RDF TriG.<br> Used in the paper "Modular Framework for Similarity-based Dataset Discovery using External Knowledge"<br> State Administration of Land Surveying and Cadastre datasets were removed from the dump for practical reasons.</p>
Data from: Validation of an algorithm for identifying MS cases in administrative health claims datasets
Objective: To develop a valid algorithm for identifying multiple sclerosis (MS) cases in administrative health claims (AHC) datasets. Methods: We used 4 AHC datasets from the Veterans Administration (VA), Kaiser Permanente Southern California (KPSC), Manitoba (Canada), and Saskatchewan (Canada). In the VA, KPSC, and Manitoba, we tested the performance of candidate algorithms based on inpatient, outpatient, and disease-modifying therapy (DMT) claims compared to medical records review using sensitivity, specificity, positive and negative predictive values, and interrater reliability (Youden J statistic) both overall and stratified by sex and age. In Saskatchewan, we tested the algorithms in a cohort randomly selected from the general population. Results: The preferred algorithm required ≥3 MS-related claims from any combination of inpatient, outpatient, or DMT claims within a 1-year time period; a 2-year time period provided little gain in performance. Algorithms including DMT claims performed better than those that did not. Sensitivity (86.6%–96.0%), specificity (66.7%–99.0%), positive predictive value (95.4%–99.0%), and interrater reliability (Youden J = 0.60–0.92) were generally stable across datasets and across strata. Some variation in performance in the stratified analyses was observed but largely reflected changes in the composition of the strata. In Saskatchewan, the preferred algorithm had a sensitivity of 96%, specificity of 99%, positive predictive value of 99%, and negative predictive value of 96%. Conclusions: The performance of each algorithm was remarkably consistent across datasets. The preferred algorithm required ≥3 MS-related claims from any combination of inpatient, outpatient, or DMT use within 1 year. We recommend this algorithm as the standard AHC case definition for MS.
Data from: Impact of an ivermectin mass drug administration on scabies prevalence in a remote Australian Aboriginal community
Background: Scabies is endemic in many Aboriginal and Torres Strait Islander communities, with 69% of infants infected in the first year of life. We report the outcomes against scabies of two oral ivermectin mass drug administrations (MDAs) delivered 12 months apart in a remote Australian Aboriginal community. Methods: Utilizing a before and after study design, we measured scabies prevalence through population census with sequential MDAs at baseline and month 12. Surveys at months 6 and 18 determined disease acquisition and treatment failures. Scabies infestations were diagnosed clinically with additional laboratory investigations for crusted scabies. Non-pregnant participants weighing ≥15 kg were administered a single 200 μg/kg ivermectin dose, repeated after 2–3 weeks if scabies was diagnosed, others followed a standard alternative algorithm. Principal Findings: We saw >1000 participants at each population census. Scabies prevalence fell from 4% at baseline to 1% at month 6. Prevalence rose to 9% at month 12 amongst the baseline cohort in association with an identified exposure to a presumptive crusted scabies case with a higher prevalence of 14% amongst new entries to the cohort. At month 18, scabies prevalence fell to 2%. Scabies acquisitions six months after each MDA were 1% and 2% whilst treatment failures were 6% and 5% respectively. Conclusion: Scabies prevalence reduced in the six months after each MDA with a low risk of acquisition (1–2%). However, in a setting where living conditions are conducive to high scabies transmissibility, exposure to presumptive crusted scabies and population mobility, a sustained reduction in prevalence was not achieved. Clinical Trial Registration: Australian New Zealand Clinical Trial Register (ACTRN—12609000654257).
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.