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20 results for “alphavirus”
Data from: Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar)
Pancreas disease (PD), caused by a salmonid alphavirus (SAV), has a large negative economic and animal welfare impact on Atlantic salmon aquaculture. Evidence for genetic variation in host resistance to this disease has been reported, suggesting that selective breeding may potentially form an important component of disease control. The aim of this study was to explore the genetic architecture of resistance to PD, using survival data collected from two unrelated populations of Atlantic salmon; one challenged with SAV as fry in freshwater (POP 1) and one challenged with SAV as post-smolts in sea water (POP 2). Analyses of the binary survival data revealed a moderate-to-high heritability for host resistance to PD in both populations (fry POP 1 h2~0.5; post-smolt POP 2 h2~0.4). Subsets of both populations were genotyped for single nucleotide polymorphism markers, and six putative resistance quantitative trait loci (QTL) were identified. One of these QTL was mapped to the same location on chromosome 3 in both populations, reaching chromosome-wide significance in both the sire- and dam-based analyses in POP 1, and genome-wide significance in a combined analysis in POP 2. This independently verified QTL explains a significant proportion of host genetic variation in resistance to PD in both populations, suggesting a common underlying mechanism for genetic resistance across lifecycle stages. Markers associated with this QTL are being incorporated into selective breeding programs to improve PD resistance.
Data from: Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar)
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Detection of small RNAs generated during early infection of human HEK 293 cells by the alphavirus Sindbis virus
GEO Series GSE46254. Homo sapiens. 3 samples. Type: Non-coding RNA profiling by high throughput sequencing.
N -acetyltransferase 10 Regulates Alphavirus Replication via the N4-acetylcytidine (ac4C) modification of lymphocyte antigen six family member E (LY6E)
GEO Series GSE222477. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
De Novo assembly and transcriptome analysis of Atlantic salmon macrophage/dendritic-like TO cells following type I IFN treatment and Salmonid alphavirus subtype-3 infection
GEO Series GSE64095. Salmo salar. 3 samples. Type: Expression profiling by high throughput sequencing.
MARCO+ lymphatic endothelial cells sequester arthritogenic alphaviruses in the draining lymph node and limit viral dissemination
GEO Series GSE174667. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Old World alphaviruses use distinct mechanisms to infect brain microvascular endothelial cells for neuroinvasion
GEO Series GSE287658. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Broad spectrum efficacy of BDGR-164 against neurotropic alphaviruses and correlates of protection
GEO Series GSE255795. Mus musculus. 28 samples. Type: Expression profiling by high throughput sequencing.
Insect-Specific Chimeric Viruses Potentiated Antiviral Responses and Inhibited Pathogenic Alphavirus Growth in Mosquito Cells
GEO Series GSE220562. Aedes albopictus. 12 samples. Type: Expression profiling by high throughput sequencing.
Dicer accumulates in cytoplasmic foci upon alphavirus infection and plays a proviral role in Myotis myotis bat cells
GEO Series GSE301457. Homo sapiens; Myotis myotis. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
A Clinical Trial of an Alphavirus Replicon Vaccine for Cytomegalovirus (CMV)
ClinicalTrials.gov study NCT00439803. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Phase 1/2 Clinical Trial of an Alphavirus Replicon Vaccine for Influenza
ClinicalTrials.gov study NCT00440362. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication
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Transcriptome analyses of Atlantic salmon muscle genes induced by DNA vaccine against salmon alphavirus subtype 3 (SAV3)
GEO Series GSE115689. Oncorhynchus mykiss; Salmo salar. 16 samples. Type: Expression profiling by array.
A commensal Clostridium bacteria restricts alphavirus dissemination through a bile acid-type I IFN signaling axis
GEO Series GSE152043. Mus musculus. 12 samples. Type: Expression profiling by array.
β-D-N(4)-hydroxycytidine is a potent anti-alphavirus compound that induces high level of mutations in viral genome
GEO Series GSE106752. Venezuelan equine encephalitis virus. 13 samples. Type: Other.
Responses of Atlantic salmon to vaccination and challenge with salmon alphavirus (SAV) and Moritella viscosa
GEO Series GSE173130. Salmo salar. 64 samples. Type: Expression profiling by array.
Gut microbe-derived short-chain fatty acids regulate joint inflammation and osteoclast activation after alphavirus infection
GEO Series GSE288863. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Other.
A commensal Clostridium bacteria restricts alphavirus dissemination through a bile acid-type I IFN signaling axis
GEO Series GSE150387. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Alphavirus infection triggers antiviral RNAi immunity in mammals
GEO Series GSE214453. Mus musculus; Homo sapiens. 41 samples. Type: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.