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6 results for “amino acid cycling”
Disruption of the TCA cycle reveals an ATF4-mediated integration of redox and amino acid metabolism
<p>The Tricarboxylic Acid (TCA) cycle is arguably the most critical metabolic cycle in physiology and exists as an essential interface coordinating cellular metabolism, bioenergetics, and redox homeostasis. Despite decades of research, a comprehensive investigation into the consequences of TCA cycle dysfunction remains elusive. Here, we targeted two TCA cycle enzymes, fumarate hydratase (FH), using an FH inhibitor (FHIN-1), and succinate dehydrogenase (SDH), using two inhibitors Atpenin A5 (AA5) and thenoyltrifluoroacetone (TTFA), and combined transcriptomics, and proteomics analyses to fully appraise the consequences of TCA cycle inhibition (TCAi) in murine kidney epithelial cell line.</p> <p>Data from this study that is included in this Dryad submission is as follows:</p> <p>1. TruSeq mRNA stranded analysis of murine Fh1<sup>fl/fl</sup> kidney epithelial cells were treated with vehicle control (DMSO) or 20 micromolar fumarate hydratase inhibitor (FHIN-1) for 24 h. Three biological replicates per condition. </p> <p>2. TruSeq mRNA stranded analysis of murine Fh1<sup>fl/fl</sup> kidney epithelial cells treated with vehicle control (DMSO) or Atpenin A5 (AA5) for 24 h. Three biological replicates per condition. </p> <p>3. Label-free proteomic analysis of a murine Fh1<sup>fl/fl</sup> kidney epithelial cells treated with vehicle control (DMSO) or 20 micromolar FHIN-1 for 24 h. Five biological replicates per condition. </p> <p>4. Label-free proteomic analysis of a murine Fh1<sup>fl/fl</sup> kidney epithelial cells treated with vehicle control (DMSO) and 500 micromolar thenoyltrifluoroacetone (TTFA). Five biological replicates per condition. </p> <p>5. Western blot uncropped blots</p>
Disruption of the TCA cycle reveals an ATF4-mediated integration of redox and amino acid metabolism
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Protein Requirements Amongst Male Masters-Level Athletes Following a Cycling Exercise Bout as Determined by the Indicator Amino Acid Oxidation Technique
ClinicalTrials.gov study NCT06431334. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Pilot Study of Combined Cycle Ergometry and Amino Acids in the ICU
ClinicalTrials.gov study NCT02822170. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The amino acid sensor GCN2 controls red blood cell life cycle and iron metabolism through regulation of tissue resident macrophages
GEO Series GSE188460. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth
GEO Series GSE236913. Saccharomyces cerevisiae. 16 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.