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ShareScore release 0.9.0
Dataset results
22 results for “aminotransferase”
Native MS dataset for: "Insights into the pathogenesis of primary hyperoxaluria type I from the structural dynamics of alanine:glyoxylate aminotransferase variants"
<p>Native mass spectrometry dataset used in: <strong>Insights into the pathogenesis of primary hyperoxaluria type I from the structural dynamics of alanine:glyoxylate aminotransferase variants.</strong> Pavla Vankova, Juan Luis Pacheco-Garcia, Dmitry S. Loginov, Atanasio Gómez-Mulas, Alan Kádek, José Manuel Martín-Garcia, Eduardo Salido, Petr Man and Angel L. Pey. FEBS Letters (2024)</p> <p><strong>Description:</strong></p> <p>Native mass spectrometry (MS) analysis verifying the oligomeric state of alanine:glyoxylate aminotransferase (AGT) protein and its P11L and I340M (LM) polymorphism and LM G170R mutation variants in primary hyperoxaluria type I.</p> <p><strong>Sample processing:</strong></p> <p>AGT protein as well as its LM and LM G130R mutants were buffer exchanged into 150 mM aqueous ammonium acetate solution (pH 7.5, MS-grade, Sigma-Aldrich) through six cycles of tenfold dilution and re-concentration using centrifugal concentrators Vivaspin 500 (30 kDa cut-off, <em>Sartorius</em>). Desalted proteins were introduced into a Synapt G2Si mass spectrometer (Waters) via static nanoelectrospray ionization from in-house prepared gold-coated borosilicate glass capillaries Kwik-Fil 1B120F-4 (<em>World Precision Instruments</em>). Protein concentration in samples was determined by 280 nm absorbance measurements using DeNovix DS-11 spectrophotometer. Samples were diluted in ammonium acetate and electrosprayed at 1 and 2 µM concentration. The mass spectrometer was carefully tuned for best signal quality and intensity, while keeping ion activation and unfolding minimal. Namely, electrospray voltage was kept at 1.3 kV, source desolvation temperature 80°C, sampling cone 80 V and 10 V collision voltage with 6 ml/min flow of argon in the trap region for thermalization of ions. Quadrupole was operated in a broadband transmission mode up to 8000 m/z while the spectra were acquired in mass range 500 – 20000 m/z. Spectra were externally mass recalibrated using known masses of caesium iodide clusters.</p> <p><strong>Data processing:</strong></p> <p>Raw mass spectra were averaged over 75 scans and further processed in Waters MassLynx 4.1. The averaged spectra were exported for ZENODO deposition as plain in plain m/z vs intensity .txt files as well uploaded as part of the .raw file format of the whole analysis (including initial metadata) with scan descriptions and parameter changes described in a stand-alone .txt descriptor file.</p>
Efficacy and Safety of 8-weeks of Glecaprevir/Pibrentasvir in Treatment-Naïve Adults With HCV Genotype 1-6 and Aspartate Aminotransferase to Platelet Ratio Index (APRI) ≤1
ClinicalTrials.gov study NCT03212521. IPD Sharing: YES. Countries: 10. Publications: 1.
Aminotransferase Trends During Prolonged Acetaminophen Dosing
ClinicalTrials.gov study NCT00743093. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Efficacy, Safety and Tolerability of Telbivudine in HBeAg Positive Chronic Hepatitis B Pregnant Women With Elevated Alanine Aminotransferase Levels
ClinicalTrials.gov study NCT01337791. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia
ClinicalTrials.gov study NCT04013555. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Compare Tenofovir DF Versus the Combination of Emtricitabine Plus Tenofovir DF for the Treatment of Chronic Hepatitis B in Patients With Normal Alanine Aminotransferase (ALT)
ClinicalTrials.gov study NCT00507507. IPD Sharing: Not stated. Countries: 11. Publications: 0.
Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome
GEO Series GSE180906. Macaca fascicularis. 2 samples. Type: Expression profiling by high throughput sequencing.
Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer
GEO Series GSE193411. Homo sapiens. 35 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
X-ray images for crystal of a protein DegT/DnrJ/EryC1/StrS family aminotransferase from Archaeoglobus veneficus
<p>X-ray images for sugar transaminase from Archaeoglobus venficus</p> <p>PDB code 7B0D</p>
The Effectiveness and Safety of Tenofovir Alafenamide in the Treatment of Chronic Hepatitis B Patients With Mildly Elevated Alanine Aminotransferase and Significant Liver Injury.
ClinicalTrials.gov study NCT04674423. IPD Sharing: NO. Countries: 1. Publications: 0.
Impact of Rosuvastatin Doses on LDL Levels, CPK Levels and Aspartate Aminotransferase Levels
ClinicalTrials.gov study NCT06910098. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Investigate the Effect of L. Lactis CKDB001 Administration on Liver Aminotransferases in Subjects With NAFLD
ClinicalTrials.gov study NCT07378280. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Pegylated-Interferon and Ribavirin in Hepatitis C Patients With Persistently Normal Alanine Aminotransferase Levels
ClinicalTrials.gov study NCT00575627. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Comparison About the Response of Ursodeoxycholic Acid in Primary Biliary Cholangitis Only and Primary Biliary Cholangitis With High Immune Globulin G or Aminotransferase at West China Hospital
ClinicalTrials.gov study NCT03322943. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Oxalate Excretion Profile in Patients with a Heterozygous Mutation of the AGXT (alanine-glyoxylate Aminotransferase) Gene
ClinicalTrials.gov study NCT06283082. IPD Sharing: NO. Countries: 1. Publications: 0.
Deep Sequencing Analysis of the MicroRNAs in the Serum of Chronic Hepatitis B with Persistently Normal Alanine Aminotransferase
GEO Series GSE62290. Homo sapiens. 3 samples. Type: Non-coding RNA profiling by high throughput sequencing.
A Study to Compare Efficacy and Safety of Tenofovir Used Alone or in Combination With Pegylated Interferon Alpha-2b in Participants With Chronic Hepatitis B and Elevated Alanine Aminotransferase (MK-4
ClinicalTrials.gov study NCT01727271. IPD Sharing: Not stated. Countries: 0. Publications: 0.
"Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial."
ClinicalTrials.gov study NCT02583841. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Immunological Measurement of Aspartate/Alanine Aminotransferase
ClinicalTrials.gov study NCT03562585. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Nitrogen-efficient rice over-expressing alanine aminotransferase
GEO Series GSE39687. Oryza sativa. 32 samples. Type: Expression profiling by array.
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