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539 results for “androgen receptor”
Trajectories and Code from "Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states" Zhu et al. 2022
<p>Trajectories, GROMACS input files, and analysis code from the manuscript "Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states" Zhu et al. 2022 (Nature Communications, In Press)</p> <p>https://www.biorxiv.org/content/10.1101/2021.12.23.474012v1.abstract</p>
177Lu-PSMA-617 vs. Androgen Receptor-Directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer
ClinicalTrials.gov study NCT04689828. IPD Sharing: YES. Countries: 14. Publications: 2.
Crucial roles of the mesenchymal androgen receptor in Wolffian duct development
<p>Wolffian duct maintenance and differentiation is predominantly driven by the androgen action, which is mediated by the androgen receptor (AR). It is well established that the mesenchyme indicates the fate and differentiation of epithelial cells. However, in vivo developmental requirement of mesenchymal AR in Wolffian duct development is still undefined. By designing a mesenchyme-specific <em>Ar</em> knockout (AR<sup>cKO</sup>), we discovered that the loss of mesenchymal <em>Ar</em> led to the bilateral or unilateral degeneration of caudal Wolffian ducts and cystic formation at the cranial Wolffian ducts. Ex vivo culture of AR<sup>cKO</sup> Wolffian ducts invariably resulted in bilateral defects, suggesting that some factor(s) originating from surrounding tissues in vivo might promote Wolffian duct survival and growth even in the absence of mesenchymal <em>Ar</em>. Mechanistically, we found cell proliferation was significantly reduced in both epithelial and mesenchymal compartments; but cell apoptosis was not affected. Transcriptomic analysis by RNA-seq of E14.5 mesonephroi revealed 131 differentially expressed genes. Multiple downregulated genes (<em>Top2a, Wnt9b, Lama2 and Lamc2</em>) were associated with morphological and cellular changes in AR<sup>cKO </sup>male embryos (i.e. reduced cell proliferation and decreased number of epithelial cells). Mesenchymal differentiation into smooth muscle cells that are critical for morphogenesis was also impaired in AR<sup>cKO </sup>male embryos. Taken together, our results demonstrate the crucial roles of the mesenchymal AR in Wolffian duct maintenance and morphogenesis in mice.</p>
Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription
<p>This repository stores the datasets for the "Decoding the Dynamic Regulation and Chromatin Architecture of Androgen Receptor-mediated Gene Expression" paper.</p>
Assessing Induction of Double Strand Breaks With Androgen Receptor Partial Agonist in Patients on Androgen Suppression
ClinicalTrials.gov study NCT03507608. IPD Sharing: NO. Countries: 1. Publications: 1.
Enzalutamide for Patients With Androgen Receptor Positive Salivary Cancers
ClinicalTrials.gov study NCT02749903. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase 1/2A Study of TRC253, an Androgen Receptor Antagonist, in Metastatic Castration-resistant Prostate Cancer Patients
ClinicalTrials.gov study NCT02987829. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study to Assess the Efficacy and Safety of Enzalutamide With Trastuzumab in Patients With Human Epidermal Growth Factor Receptor 2 Positive (HER2+), Androgen Receptor Positive (AR+) Metastatic or Lo
ClinicalTrials.gov study NCT02091960. IPD Sharing: YES. Countries: 6. Publications: 1.
Safety and Efficacy Study of Enzalutamide in Patients With Advanced, Androgen Receptor-Positive, Triple Negative Breast Cancer
ClinicalTrials.gov study NCT01889238. IPD Sharing: YES. Countries: 7. Publications: 2.
A Selective Androgen Receptor Modulator for Symptom Management in Prostate Cancer
ClinicalTrials.gov study NCT02499497. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Evaluate the Safety and Efficacy of 13 Weeks of the Selective Androgen Receptor Modulator (SARM) GSK2881078 in Chronic Obstructive Pulmonary Disease (COPD)
ClinicalTrials.gov study NCT03359473. IPD Sharing: Not stated. Countries: 3. Publications: 2.
Crucial roles of the mesenchymal androgen receptor in Wolffian duct development
Open the record for dataset details and reuse information.
Data from: Identification of druggable targets from the interactome of the Androgen Receptor and Serum Response Factor pathways in prostate cancer
Open the record for dataset details and reuse information.
Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis)
Background: The androgen receptor, an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen receptor gene in carnivores reported somatic mosaicism in the tissues of a number of species including Eurasian lynx (Lynx lynx). We investigated this claim in a closely related species, Canada lynx (Lynx canadensis). The presence of somatic mosaicism in lynx tissues could have implications for the future study of exonic trinucleotide repeats in landscape genomic studies, in which the accurate reporting of genotypes would be highly problematic. Methods: To determine whether mosaicism occurs in Canada lynx, two lynx individuals were sampled for a variety of tissue types (lynx 1) and tissue locations (lynx 1 and 2), and 1,672 individuals of known sex were genotyped to further rule out mosaicism. Results: We found no evidence of mosaicism in tissues from the two necropsied individuals, or any of our genotyped samples. Conclusions: Our results indicate that mosaicism does not manifest in Canada lynx. Therefore, the use of hide samples for further work involving trinucleotide repeat polymorphisms in Canada lynx is warranted.
A Phase I Study of a DNA Vaccine Encoding Androgen Receptor Ligand-Binding Domain (AR LBD) +/-GMCSF
ClinicalTrials.gov study NCT02411786. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Safety and Pharmacokinetics Study of Niraparib Plus an Androgen Receptor-Targeted Therapy in Men With Metastatic Castration-Resistant Prostate Cancer (BEDIVERE)
ClinicalTrials.gov study NCT02924766. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Androgen Receptor Directed Therapy on Cognitive Function in Patients Treated With Darolutamide or Enzalutamide
ClinicalTrials.gov study NCT04335682. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Analysis of Androgene Receptors Axis and DNA Damage Repair Genes in Patients With Prostate Cancer
ClinicalTrials.gov study NCT03677414. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Apa/Enza-short Study: Shorter Treatment With Androgen Receptor Pathway Inhibitor in Patients With Low-volume Metastatic Castration-sensitive Prostate Cancer
ClinicalTrials.gov study NCT07260435. IPD Sharing: Not stated. Countries: 1. Publications: 16.
Prognostic Value of Androgen Receptor Expression and Mutations Within Oncogenes and Tumor Suppressor Genes in Patients Treated for High Risk Prostate Cancer With Proton Therapy (PRX32)
ClinicalTrials.gov study NCT03296124. IPD Sharing: NO. Countries: 1. Publications: 17.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.