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161 results for “aneuploidy”
Recombination and aneuploidy data for: Insights about variation in meiosis from 31,228 human sperm genomes
<p>This repository holds crossover and aneuploidy data for 31,228 human sperm genomes sequenced with Sperm-seq. Data are described in the preprint/paper "Insights about variation in meiosis from 31,228 human sperm genomes." Several levels of data are available, e.g., each crossover (allcrossovers_hg38.txt.gz) and the numbers of crossovers detected per sperm cell (numbercrossoverspercell.txt.gz). Each data file is described in its own readme, so README_allgainsdivisionoforigin.txt explains the data present in allgainsdivisionoforigin.txt. All files are either text files or text files compressed via gzip. All data was generated as described in the preprint/paper, using scripts available in the companion repository (most recent version DOI: 10.5281/zenodo.3561080).</p> <p>This new version has updated sex chromosome ploidies after identifying a minor coding error affecting ~24 cells (sexchromosomeploidy.txt.gz) and includes more detail about possible crossover error modes (README_allcrossovers_hg38.txt.gz).</p>
Use of a Novel Computerized Decision Aid for Prenatal Aneuploidy Screening
ClinicalTrials.gov study NCT02991729. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Aneuploidy causes non-genetic individuality
Phenotypic variability is a hallmark of diseases involving chromosome gains and losses, such as Down syndrome and cancer. Allelic variances have been thought to be the sole cause of this heterogeneity. Here, we systematically examine the consequences of gaining and losing single or multiple chromosomes to show that the aneuploid state causes non-genetic phenotypic variability. Yeast cell populations harboring the same defined aneuploidy exhibit heterogeneity in cell-cycle progression and response to environmental perturbations. Variability increases with degree of aneuploidy and is partly due to gene copy number imbalances, suggesting that subtle changes in gene expression impact the robustness of biological networks and cause alternate behaviors when they occur across many genes. As inbred trisomic mice also exhibit variable phenotypes, we further propose that non-genetic individuality is a universal characteristic of the aneuploid state that may contribute to variability in presentation and treatment responses of diseases caused by aneuploidy.
AneuploidyML_Datasets: Machine-learning analysis of factors that shape cancer aneuploidy landscapes reveals an important role for negative selection
<p>This is raw data that were used to build the processed dataset for training and testing the machine learning</p>
VAlidation of a Lower Cost aneUploidy scrEen
ClinicalTrials.gov study NCT03087357. IPD Sharing: NO. Countries: 3. Publications: 3.
A Study of the Effects of a Novel Ovarian Stimulation Regimen on Embryo Aneuploidy Rates in In Vitro Fertilization (IVF)
ClinicalTrials.gov study NCT00866008. IPD Sharing: Not stated. Countries: 1. Publications: 1.
SNP-based Microdeletion and Aneuploidy RegisTry (SMART)
ClinicalTrials.gov study NCT02381457. IPD Sharing: Not stated. Countries: 6. Publications: 25.
Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Couples With Non-obstructive Azoospermia (NOA)
ClinicalTrials.gov study NCT06566599. IPD Sharing: NO. Countries: 1. Publications: 8.
Screening of Low Responders for Aneuploidy to Improve Reproductive Efficiency
ClinicalTrials.gov study NCT01977144. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Aneuploidies and Different Stimulation Protocols
ClinicalTrials.gov study NCT00802295. IPD Sharing: Not stated. Countries: 1. Publications: 1.
RCT of niPGT for Aneuploidy and Morphology Compared With Morphology Alone in IVF
ClinicalTrials.gov study NCT04474522. IPD Sharing: NO. Countries: 1. Publications: 12.
Preimplantation Genetic Testing for Aneuploidy Counseling
ClinicalTrials.gov study NCT06018454. IPD Sharing: NO. Countries: 1. Publications: 8.
Evaluation of Ultrasensitive Chromosomal Aneuploidy Detection for Detecting Minimal Residual Disease in Multiple Myeloma
ClinicalTrials.gov study NCT04122092. IPD Sharing: UNDECIDED. Countries: 1. Publications: 8.
Embryo Aneuploidies and Ovarian Stimulation
ClinicalTrials.gov study NCT00707525. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Investigation of the Impact of Noninvasive Prenatal Testing for Fetal Aneuploidy on Utilization of Prenatal Diagnostic Procedures and Pregnant Women's Views
ClinicalTrials.gov study NCT01708746. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Does an Educational Video for Aneuploidy Screening Improve Informed Choice Among Pregnant Women?
ClinicalTrials.gov study NCT05492981. IPD Sharing: NO. Countries: 1. Publications: 1.
Non-Invasive Screening for Fetal Aneuploidy
ClinicalTrials.gov study NCT02317965. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Comparison of Aneuploidy Risk Evaluations
ClinicalTrials.gov study NCT01663350. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Aneuploidies in Embryos and Spermatozoa From Patients With Y-chromosome Microdeletions
ClinicalTrials.gov study NCT02527954. IPD Sharing: Not stated. Countries: 1. Publications: 27.
Impact of Dry vs Humidified Culture Conditions on Blastocyst Development and Aneuploidy: A Time-lapse Sibling Oocyte Study
ClinicalTrials.gov study NCT07270250. IPD Sharing: NO. Countries: 1. Publications: 6.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.