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Dataset results
226 results for “anti-inflammatory effect”
Study to Examine the Clinical Efficacy and the Nonsteroidal Anti-inflammatory Drug (NSAID)-Sparing Effect of Secukinumab Over 16 Weeks in Patients With Ankylosing Spondylitis
ClinicalTrials.gov study NCT02763046. IPD Sharing: YES. Countries: 1. Publications: 1.
Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
<p class="MsoNormal"><span><strong>Background:</strong> Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. It's final neurological outcome determined from both primary and secondary injury process. Neuroinflammation is a key component of the secondary injury mechanisms with local and systemic consequences. </span>A neuroprotective compound, ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup>also known as Semax has <span>shown neuroprotective and anti-inflammatory properties. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> <span>also has actively used in the treatment of brain ischemia without serious complication reported. Here we analyzed the effects of </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> in regulating inflammatory cascade in SCI by looking at the expression of anti-inflammatory cytokine IL-4, IL-10, IL-13 in acute compression SCI.</p> <p><span><strong>Method: </strong>We do laminectomy in Sprague Dawley rats at the second thoracic vertebrae. After laminectomy we expose the myelum and create mild SCI model with 20gr and severe SCI with 35gr aneurysm clips. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup><span>was administered intranasally to the treatment group and 0,9% NaCl to the control group (placebo). Both group was remain alive and terminated at 3 and 6 hour. </span>The preparations tissue sample were fixed in formalin and examined for immunohistochemistry<span>. Quantitative measurement of anti-inflammatory cytokine (</span>IL-4, IL-10, IL-13) was done in posterior horn with associated anti-monoclonal antibodies.</p> <p> </p> <p><strong>Result:</strong> Rats with mild SCI that were given ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> shown greater expression of IL-4, IL-10 and IL-13 at three hour post compression but only IL-10 and IL-13 elevated significantly at six hour. Rats with severe compression in ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> group shown greater expression of IL-10, IL-13 at three hour and IL-4, IL-10 at six hour compared with the placebo group.</p> <p> </p> <p><strong>Conclusion: </strong>Administration of ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> intranasal can increase anti inflammatory cytokine expression at Sprague Dawley rat model with mild and severe SCI. Expression of anti inflammatory cytokine was greater in mild compression and early hour (3 hour). Further research needs to be done to determine optimal dose and the actual clinical outcome in vivo.</p>
The Effects of Anti-Inflammatory Treatment on Insulin Resistance in Healthy Volunteers
ClinicalTrials.gov study NCT00339833. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Assessment of the Anti-inflammatory Effects of Norflo Oro in Acute Relapses of HLA-B27 Associated Autoimmune Uveitis
ClinicalTrials.gov study NCT03584724. IPD Sharing: NO. Countries: 1. Publications: 4.
Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock
ClinicalTrials.gov study NCT02633358. IPD Sharing: NO. Countries: 1. Publications: 8.
Anti-inflammatory Effects of Colchicine in PCI
ClinicalTrials.gov study NCT01709981. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Trial to Assess the Anti-inflammatory Effects of Roflumilast in Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT01509677. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL
ClinicalTrials.gov study NCT02998918. IPD Sharing: NO. Countries: 1. Publications: 24.
The Anti-inflammatory Effect of Prophylactic Macrolides on Children With Chronic Lung Disease
ClinicalTrials.gov study NCT02544984. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Antiplatelet and Anti-inflammatory Effects of Statins and Ezetimibe
ClinicalTrials.gov study NCT00474123. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of the Anti-Inflammatory Effects of Colgate Total® During an Experimental Gingivitis Model
ClinicalTrials.gov study NCT01799226. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Rosuvastatin Response in Healthy Subjects: Potential Mechanisms of Anti-inflammatory Effects
ClinicalTrials.gov study NCT00874757. IPD Sharing: NO. Countries: 1. Publications: 5.
Effect Of Pregabalin Treatment In Patients With Diabetic Nerve Pain Who Currently Use A Non-Steroid Anti-Inflammatory Drug (NSAID) For Another Pain
ClinicalTrials.gov study NCT01455415. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Investigating the Anti-Human Immunodeficiency Virus (HIV) & Anti-inflammatory Effect of Chloroquine
ClinicalTrials.gov study NCT00308620. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ADOAIR250 Anti-inflammatory Effects in Japanese Subjects With Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT01607398. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
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Data from: Diosmin and its glycocalyx restorative and anti-inflammatory effects on injured blood vessels
<p>Endothelium, a crucial homeostatic organ, regulates vascular permeability and tone. Under physiological conditions, endothelial stimulation induces vasodilator endothelial nitric oxide (eNO) release and prevents adhesion molecule accessibility and leukocyte adhesion and migration into vessel walls. Endothelium dysfunction is a principal event in cardiovascular disorders, including atherosclerosis. Hence, current therapies focus on endothelium repair to prevent downstream cardiovascular events. However, minimal attention is given to the restoration of mechanotransducer endothelial glycocalyx (GCX), a negatively charged heterogeneous polysaccharide, which covers and protects endothelial cells. Endothelial GCX shedding plays a role in endothelial dysfunction, increasing vascular permeability and decreasing vessel tone. Diosmin, a flavone glycoside of diosmetin, downregulates adhesive molecule expression, decreases inflammation and capillary permeability, and upregulates eNO expression. Due to these pleiotropic effects of diosmin on the vasculature, a possible unidentified mechanism of action is through GCX restoration. Diosmin effect on GCX and endothelial function were assessed in a partial ligation left carotid artery (LCA) mouse model where the right carotid artery was the control for each mouse. Diosmin (50 mg/kg) was administered daily for 7 days, 48 hours after ligation. Within the ligated mice LCAs, diosmin treatment elevated the activated eNO synthase level, inhibited inflammatory cell uptake, decreased vessel wall thickness, increased vessel diameter, and increased GCX coverage of the vessel wall. ELISA showed a decrease in hyaluronan concentration in plasma samples of diosmin-treated mice, signifying reduced GCX shedding. In summary, diosmin supported endothelial GCX integrity, which preserved endothelial function by attenuating expression of inflammatory factors and restoring vascular tone.</p>
Measurement of TNF‐α, CK-MB, LDH, IL‐1 and IL-6 levels for anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study
<p>Measurement of TNF‐α, CK-MB, LDH, IL‐1 and IL-6 levels for anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study</p>
The ARRIVE Essential 10: author checklist – Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study
<p>The ARRIVE Essential 10: author checklist – Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study</p>
The ARRIVE Essential 10: author checklist – Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study
<p><a href="https://zenodo.org/deposit/7360384">The ARRIVE Essential 10: author checklist – Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study</a></p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.