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8 results for “antibody‐dependent enhancement”
Modelling the impact of antibody-dependent enhancement on disease severity of ZIKV and DENV sequential and co-infection
<p>Human infections with viruses of the genus <em>Flavivirus</em>, including dengue virus (DENV) and Zika virus (ZIKV), are of increasing global importance. Due to antibody dependent enhancement, secondary infection with one <em>Flavivirus</em> following primary infection with another {\it Flavivirus} can result in a significantly larger peak viral load with a much higher risk of severe disease. Although several mathematical models have been developed to quantify the virus dynamics in the primary and secondary infections of DENV, little progress has been made regarding secondary infection of DENV after a primary infection of ZIKV, or DENV-ZIKV co-infection. Here, we address this critical gap by developing compartmental models of virus dynamics. We first fitted the models to published data on dengue viral loads of the primary and secondary infections with the observation that the primary infection reaches its peak much more gradually than the secondary infection. We then quantitatively show that antibody dependent enhancement (ADE) is the key factor determining a sharp increase/decrease of viral load near the peak time in the secondary infection. In comparison, our simulations of DENV and ZIKV co-infection (simultaneous rather than sequential) show that ADE has very limited influence on the peak DENV viral load. This indicates pre-existing immunity to ZIKV is the determinant of a high level of ADE effect. Our numerical simulations show that 1) in the absence of ADE effect, a subsequent co-infection is beneficial to the second virus; 2) if ADE is feasible, then a subsequent co-infection can induce greater damage to the host with a higher peak viral load and a much earlier peak time for the second virus, and for the second peak for the first virus.</p>
Modelling the impact of antibody-dependent enhancement on disease severity of ZIKV and DENV sequential and co-infection
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Data from: Mosquito saliva increases endothelial permeability in the skin, immune cell migration, and dengue pathogenesis during antibody-dependent enhancement
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Time-dependent enhancement of mRNA vaccines by 4-1BB costimulatory antibodies
GEO Series GSE260817. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection.
GEO Series GSE264625. Homo sapiens. 12 samples. Type: Other.
Supplementary Data: Antibody-dependent Enhancement of 2019-nCoV Infection, a Major Concern for Prevention
<p>Less than two months after the new coronavirus raged, it has already become a public health problem in the world. Till today, the infectivity and lethality of the virus are not clear enough. Zhongnan Hospital of Wuhan University described in detail the clinical characteristics of 138 hospitalized patients with novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) in Wuhan1. It reported that the in-hospital mortality was 4.3%, which is close to the data in Wuhan (4.1%) but twice the national average (2.0%). The data as of February 9, 2020, shows that the mortality in Wuhan City, Hubei Province, is higher than the average value of other cities in the province (1.5%), and is even higher than the national average except Hubei Province (0.59%). The much higher mortality in Wuhan compared to the whole country raises confusion in people. One possible, but certainly not entirely explained, reason for this phenomenon is the antibody-dependent enhancement (ADE) of 2019-nCoV infection, which we should pay more attention to the future plague prevention.</p>
Viral infection enhances NK cell activation via Type I dependent pathways and can be utilized to enhance influenza-specific monoclonal antibody therapies
GEO Series GSE115203. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
The expression profile of human peripheral blood mononuclear cells miRNA is altered by dengue virus serotype-3 and antibody-dependent enhancement infection
GEO Series GSE98859. Homo sapiens. 5 samples. Type: Non-coding RNA profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.