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12
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ShareScore release 0.9.0
Dataset results
12 results for “anticholinergic burden”
The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery
ClinicalTrials.gov study NCT06349057. IPD Sharing: NO. Countries: 1. Publications: 3.
The Relationship Between Anticholinergic Burden and Postoperative Complications After Cardiac Surgery in Older Adults
ClinicalTrials.gov study NCT05312684. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Intervention to REduce anticholinerGic burdEN in oldER pATiEnts (REGENERATE) Aged 65 Years and Older
ClinicalTrials.gov study NCT04660838. IPD Sharing: NO. Countries: 1. Publications: 10.
Anticholinergic Burden - Treatment Optimization
ClinicalTrials.gov study NCT03208569. IPD Sharing: NO. Countries: 1. Publications: 1.
The Effects Of Anticholinergic Burden On Daily Living Activities In Elderly Patients
ClinicalTrials.gov study NCT05902676. IPD Sharing: UNDECIDED. Countries: 0. Publications: 4.
Anticholinergic Burden and Osteoporosis in Rheumatoid Arthritis
ClinicalTrials.gov study NCT06812481. IPD Sharing: NO. Countries: 1. Publications: 0.
Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia:
ClinicalTrials.gov study NCT05055895. IPD Sharing: NO. Countries: 1. Publications: 0.
Anticholinergic Burden in Schizophrenia
ClinicalTrials.gov study NCT00715377. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact in Older Adults of Reducing Anticholinergic and Sedative Rx Burden on Physical Function Measured by Wearables
ClinicalTrials.gov study NCT05735379. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Effect of the Anticholinergic Drug Burden on Postoperative Delirium in Elderly Chinese Patients: A Nested Case-Control Study
ClinicalTrials.gov study NCT06931353. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study on Anticholinergic Use: Attribution of Overactive Bladder (OAB) Medications to the Anticholinergic Burden
ClinicalTrials.gov study NCT03903094. IPD Sharing: NO. Countries: 2. Publications: 0.
Dataset related to the article "Relation between anticholinergic burden and cognitive impairment: Results from the Monzino 80-plus population-based study"
<p><em>The file contains raw data related to the article "Relation between anticholinergic burden and cognitive impairment: Results from the Monzino 80-plus population-based study", available from <a href="https://onlinelibrary.wiley.com/doi/10.1002/pds.5159">https://onlinelibrary.wiley.com/doi/10.1002/pds.5159</a>.</em></p> <p> </p> <p><strong>Abstract of the manuscript:</strong></p> <p><strong>Purpose: </strong>We examined data collected in the Monzino 80-plus study to assess the relations between cognitive performance and ACB scores according to the hypothesis that a higher anticholinergic burden is associated with reduced cognitive performance.</p> <p><strong>Methods: </strong>The Monzino 80-plus is an ongoing, prospective, door-to-door population-based study started in 2002 among all residents 80 years or older in eight municipalities of Varese province, Italy. To establish the relation between cognitive impairment and the anticholinergic drug burden we recorded the ACB score for each patient at baseline. The relations between ACB score and dementia or MMSE scores were also examined after exclusion of patients taking any antipsychotic.</p> <p><strong>Results: </strong>A sample of 2140 elderly people was eligible for analysis. A significant dose-effect relationship was observed between total ACB score and diagnosis of dementia in univariate and multivariate models. Patients in ACB class ≥4 had about 4.5 times the risk of diagnosis of dementia. A relation was also found between higher ACB scores and lower MMSE scores; patients who scored 4 or more had a mean of 6.4 points lower than those not taking anticholinergic drugs. The dose-effect relationship between ACB score and diagnosis of dementia was not maintained after exclusion of patients using antipsychotics, while the association between higher ACB scores and lower MMSE scores was still present, with patients in ACB class ≥4 having a mean score about 4.4 lower.</p> <p><strong>Conclusions: </strong>There are clear relations between anticholinergic load and reduced cognitive performance, while the association with dementia remains uncertain. For primary care and geriatric clinicians, an ACB score ≥ 4 can be considered the cut-off to identify high-risk populations who may benefit from the evaluation of anticholinergic burden with the ACB scale.</p>
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