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30 results for “antimalarial drugs”
Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis.
ClinicalTrials.gov study NCT02564471. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Assessment of markers of antimalarial drug resistance in Plasmodium falciparum isolates from pregnant women in Lagos, Nigeria
Background: The use of antimalarial drugs for prevention and treatment is a major strategy in the prevention of malaria in pregnancy. Although sulphadoxine-pyrimethamine (SP) is currently recommended for intermittent preventive treatment of malaria during pregnancy in Nigeria, previously used drugs for prophylaxis such as chloroquine (CQ) and pyrimethamine are accessible as they are purchased over the counter. This study describes the markers of absence or presence of resistance to quinoline (Pfcrt and Pfmdr 1) and type 1 antifolate antimalarial medicines (Pfdhfr). Methods: Plasmodium falciparum-positive dried blood spots from pregnant women attending antenatal clinics for the first time during current pregnancy were investigated for the presence of mutations at codons 72–76 of Plasmodium falciparum chloroquine resistance transporter (Pfcrt) gene by real time polymerase chain reaction (PCR) using haplotype-specific probes. PCR followed by sequence analysis was used to identify mutations at codons 86, 184, 1034, 1042 and 1246 of P. falciparum multi-drug resistance-1 (Pfmdr1) gene; and codons 16, 50, 51, 59, 108, 140 and 164 of Pfdhfr gene. Results: Two haplotypes of Pfcrt (n = 54) were observed: CVMNK 13(24.2%) and CVIET 41 (75.9%) of the samples. The SVMNT haplotype was absent in this population. The Pfmdr1 (n = 28) haplotypes were NYSND 15(53.6%), YYSND 5(17.9%), NFSND 6(21.4%) and YFSND 2(7.1%). The Pfdhfr (n = 15) were ACNCSVI 4(26.7%), and ACICNSVI 1(6.7%) and ACIRNVI 10 (66.7%). The rate of occurrence of Pfcrt 76T, Pfdhfr108N, Pfmdr186Yand184F were 75.9%, 73.3%, 25% and 28.1% respectively. The Pfmdr1 86Y was associated with low parasitaemia (median = 71 parasites/μl, P = 0.024) while Pfcrt 76T was associated with young maternal age (mean 24.1 ± 4.5 years; P = 0.006). The median parasitaemia were similar (P>0.05) in wild and mutant strains of Pfcrt 76, Pfmdr1 184 and Pfdhfr 108. There was no association between gravidity or gestational age of the women and presence of mutations in the Pfcrt, Pfmdr1 or Pfdhfr genes (P>0.05). Conclusion: Markers of resistance to chloroquine and pyrimethamine were high, whereas cycloguanil-resistance marker was not present in the studied population. The low level of mutations in the Pfmdr1gene indicates likely efficacy of amodiaquine against malaria in pregnancy.
Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria Challenge
ClinicalTrials.gov study NCT02639299. IPD Sharing: NO. Countries: 1. Publications: 1.
Antimalarial Drug Resistance in Mali
ClinicalTrials.gov study NCT00127998. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Efficacy of Antimalarial Drugs Used for the Treatment of Uncomplicated Malaria, Plasmodium Falciparum, at the Agadez, Gaya and Tessaoua Sentinel Sites
ClinicalTrials.gov study NCT05070520. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
A Trial of Antimalarial Drugs Used in Pregnancy in Tanzania
ClinicalTrials.gov study NCT00146731. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prevalence Survey of Plasmodium Falciparum Antimalarial Drug Resistance Markers
ClinicalTrials.gov study NCT02895568. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Antimalarial Drug Resistance With Assessment of Transmission Blocking Activity
ClinicalTrials.gov study NCT01849640. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Adherence to Antimalarial Drugs in Sierra Leone
ClinicalTrials.gov study NCT01967472. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Association Between Drug Levels, Malaria, and Antimalarial Resistance in the Setting of Seasonal Malaria Chemoprevention
ClinicalTrials.gov study NCT04969185. IPD Sharing: NO. Countries: 1. Publications: 1.
Evaluation of Alternative Antimalarial Drugs for Malaria in Pregnancy
ClinicalTrials.gov study NCT00811421. IPD Sharing: Not stated. Countries: 5. Publications: 16.
A Pilot Study to Test Activity of Antimalarial Drugs Against an Induced Malaria Infection in Healthy Volunteers
ClinicalTrials.gov study NCT01055002. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Add on to Azythromycine, Phytomedicine and/or Antimalarial Drug vs Hydroxychloroquine in Uncomplicated COVID-19 Patients
ClinicalTrials.gov study NCT04502342. IPD Sharing: YES. Countries: 1. Publications: 15.
Monitoring Pregnant Women for Antimalarial Drug Resistance
ClinicalTrials.gov study NCT05072613. IPD Sharing: NO. Countries: 1. Publications: 5.
Data from: Assessment of markers of antimalarial drug resistance in Plasmodium falciparum isolates from pregnant women in Lagos, Nigeria
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Rapid multiplexed nanopore amplicon sequencing to distinguish Plasmodium falciparum recrudescence from new infection in antimalarial drug trials
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Evaluation of Oral Activated Charcoal on Antimalarial Drug's Ability to Kill Parasites in Malian Children With Malaria
ClinicalTrials.gov study NCT01955382. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model
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Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
GEO Series GSE32485. Plasmodium falciparum. 6 samples. Type: Genome variation profiling by genome tiling array.
Expression data from early response of Saccharomyces cerevisiae to the antimalarial drug quinine
GEO Series GSE18037. Saccharomyces cerevisiae. 4 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.