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ShareScore release 0.9.0
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9 results for “aspartame”
Data from: Effects of high dose aspartame-based sweetener on the gut microbiota and bone strength in young and aged mice
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Early-life exposures to diet soda and aspartame are associated with autism in males
<p>Since its introduction, aspartame—the leading sweetener in U.S. diet sodas (DS)—has been reported to cause neurological problems in some users. In prospective studies, the offspring of mothers who consumed diet sodas/beverages (DSB) daily during pregnancy experienced increased health problems. We hypothesized that gestational/early-life exposure to ≥1 DS/day (DS<sub>early</sub>) or equivalent aspartame (ASP<sub>early</sub>: ≥177 mg/day) increases autism risk. The case-control Autism Tooth Fairy Study obtained retrospective dietary recalls for DSB and aspartame consumption during pregnancy/breastfeeding from the mothers of 235 offspring with autism spectrum disorder (ASD: cases) and 121 neurotypically developing offspring (controls). The exposure odds ratios (ORs) for DS<sub>early</sub> and ASP<sub>early</sub> were computed for autism, ASD, and the non-regressive conditions of each. Among males, DS<sub>early</sub> odds were tripled among autism (OR = 3.1; 95% CI: 1.02, 9.7) and non-regressive autism (OR = 3.5; 95% CI: 1.1, 11.1) cases; ASP<sub>early</sub> odds were even higher: OR = 3.4 (95% CI: 1.1, 10.4) and 3.7 (95% CI: 1.2, 11.8), respectively, among autism and non-regressive autism cases (p < 0.05 for each). ORs for non-regressive ASD in males were almost tripled but were not statistically significant: DS<sub>early</sub> OR = 2.7 (95% CI: 0.9, 8.4); ASP<sub>early</sub> OR = 2.9 (95% CI: 0.9, 8.8). No statistically significant associations were found in females. Our findings contribute to the growing literature raising concerns about potential offspring harm from maternal DSB/aspartame intake in pregnancy.</p>
Early-life exposures to diet soda and aspartame are associated with autism in males
Open the record for dataset details and reuse information.
The Effects of Aspartame on Appetite, Body Composition and Oral Glucose Tolerance
ClinicalTrials.gov study NCT02999321. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Cellular stress, inflammation and barrier damage in gut epithelial cells caused by aspartame
GEO Series GSE285905. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Study of the Reversibility of Glucose Intolerance Caused by Chronic Aspartame Consumption
ClinicalTrials.gov study NCT02520258. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of developmental NMDAR antagonism on aspartame-induced hypothalamic and adrenal gene expression
GEO Series GSE100326. Mus musculus. 24 samples. Type: Expression profiling by array.
Transgenerational transmission of aspartame induced anxiety and changes in glutamate-GABA signaling and gene expression in the amygdala
GEO Series GSE210561. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
The effect of aspartame on the innate immune ability of Caenorhabditis elegans.
GEO Series GSE273859. Caenorhabditis elegans. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.