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546 results for “atypical”
Discrimination of Classical and Atypical BSE by a Distinct Immunohistochemical PrPSc Profile
<p>Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disease in cattle belonging to the group of transmissible spongiform encephalopathies. Hallmark of the disease is the accumulation of the pathological prion protein (PrPSc) in the brain. Classical BSE (C-type) and two atypical BSE forms (L- and H-type) are known, and can be discriminated by biochemical characteristics. The data presented here underline that immunohistochemistry can also be used to identify type-specific PrPSc profiles which can be used for discriminatory purposes. For this brain samples from 21 cattle, intracerebrally inoculated with C-, H-, and L-type BSE, were used as well as three orally C-type BSE infected animals. Using six brain regions distinct lesion (H&E staining) and PrPSc profiles were determined. While the neuroanatomical distribution of lesions and the PrPSc accumulation were highly consistent between the groups, the topographic and cellular PrPSc profile revealed characteristic pattern for the different BSE types.</p>
Dataset related to article "Molecular Studies and ex vivo Complement assay on Endothelium Highlight the Genetic Complexity of Atypical Hemolytic Uremic Syndrome: The Case of a Pedigree With a Null CD46 Variant".
<p><em>The files contain raw data related to the article "Molecular Studies and ex vivo Complement assay on Endothelium Highlight the Genetic Complexity of Atypical Hemolytic Uremic Syndrome: The Case of a Pedigree With a Null CD46 Variant", available from <a href="https://www.frontiersin.org/articles/10.3389/fmed.2020.579418/full">https://www.frontiersin.org/articles/10.3389/fmed.2020.579418/ful</a>l.</em></p> <p>File <strong>"Genetic and clinical data"</strong>:</p> <ul> <li>In the sheet "485 aHUS patients" are reported data obtained from the screening of 485 unrelated patients with aHUS including rare variants (RVs) in complement disease-associated genes (<em>CFH, CD46, CFI, C3, CFB </em>and <em>THBD</em>), the presence of <em>CFH-CFHR</em> genomic rearrangements and/or anti-FH antibodies.</li> <li>In the sheet "Pedigrees with c.286+2T>G" are listed all pedigrees carrying the c.286+2T>G variant, the diseases status of all subjects and the age of disease onset of patients. In bold are indicated pedigrees (n=7) used to study the penetrance of aHUS in c.286+2T>G carriers.</li> <li>In the sheet "Haplotypes" are reported genotypes used to evaluate the association between the presence of <em>CFH-H3</em> and <em>CD46<sub>GGAAC</sub></em> risk haplotypes and aHUS. Results of this analysis are reported in Table 3 of the published paper.</li> <li>In the sheet "Raw data Fig.2" are reported data of "platelet count" and "serum creatinine" of the proband used to elaborate Figure 2.</li> </ul> <p>In the file <strong>"C3 and C5b-9 deposition"</strong> is reported the quantification of serum-induced C3 and C5b-9 deposition on human microvascular endothelial cell line (HMEC-1). The fluorescent staining was evaluated with Image J and expressed as pixel<sup>2 </sup>per field analyzed. The fields with the lowest and highest values were excluded from calculation. These values were used to elaborate data included in Table 2 and in Figure 5.</p> <p>In the file <strong>"CD46 protein expression"</strong> are reported data of CD46 expression on peripheral blood mononuclear cells (PBMCs) isolated from the proband, his relatives and healthy volunteers. Data of specific expression of CD46 (evaluated for SCR1 or for SCR4 as reported in the materials and methods section) are indicated as median fluorescence intensity (MFI) percentage compared with the control.</p> <p>In the ppt file <strong>"cDNA amplification and sequencing results"</strong> is reported:</p> <ul> <li>the agarose gel image of the amplified cDNA from the control (ctr), the proband (IV-8) and his healthy father (III-7).</li> <li>Electropherograms obtained from the cDNA sequencing of the control (ctr), the proband (IV-8) and his healthy father (III-7).</li> </ul> <p>Additional data will be made available by the authors, without undue reservation, to any qualified researcher. </p>
Fig. 8 in Two atypical new species of the genus Sectonema Thorne, 1930 (Nematoda, Dorylaimida, Aporcelaimidae) from Vietnam
Fig. 8. Sectonema vietnamense sp. nov. (LM, type population). A. ♁, entire. B–C. Anterior region in lateral, median view. D. ♀, anterior genital branch. E. ♁, posterior body region. F. Oviduct-uterus junction. G. Lip region in lateral, surface view. H. Vagina. I. ♁, caudal region. J–K. Spicules. L. ♀, caudal region. Scale bars: A = 500 μm; B–C, H = 10 μm; D = 100 μm; E–F = 50 μm; G = 5 μm; I–L = 20 μm.
Fig. 7 in Two atypical new species of the genus Sectonema Thorne, 1930 (Nematoda, Dorylaimida, Aporcelaimidae) from Vietnam
Fig. 7. Sectonema vietnamense sp. nov. (Line). A. Anterior region in median, lateral view. B. Lip region in surface, lateral view. C. Neck region. D. Vagina. E. ♀, anterior genital branch. F. ♁, entire. G. ♀, entire. H. ♁, posterior body region. I. ♀, posterior body region. J. Spicule. K. Lateral guiding piece.
Fig. 5. Bayesian 50 in Two atypical new species of the genus Sectonema Thorne, 1930 (Nematoda, Dorylaimida, Aporcelaimidae) from Vietnam
Fig. 5. Bayesian 50% majority rule consensus trees as inferred from D2–D3 expansion segments of 28S rRNA gene sequence alignments under the GTR + I + G model. Posterior probabilities are given for appropriate clades. Newly obtained sequences are indicated by bold letters.
Fig. 3 in Two atypical new species of the genus Sectonema Thorne, 1930 (Nematoda, Dorylaimida, Aporcelaimidae) from Vietnam
Fig. 3. Sectonema tropicum sp. nov. (LM). A. ♁, posterior body region. B. ♀, posterior body region. C. ♀, caudal region. D. ♁, caudal region. E–G. Spicules, E–F also showing the lateral guiding piece. Scale bars: A–B = 20 μm; C–G = 10 μm.
Fig. 2 in Two atypical new species of the genus Sectonema Thorne, 1930 (Nematoda, Dorylaimida, Aporcelaimidae) from Vietnam
Fig. 2. Sectonema tropicum sp. nov. (LM). A, C, E. Anterior region in lateral, median view. B. Lip region in lateral, surface view. D. Neck region. F. Pharyngo-intestinal junction. G. Vagina. H. ♀, anterior genital branch. I. Vagina and anterior uterus containing sperm cells inside. J. Uterine egg. Scale bars: A–B, E, G = 10 μm; C, F, I–J = 20 μm; D, H = 50 μm.
Fig. 1 in Two atypical new species of the genus Sectonema Thorne, 1930 (Nematoda, Dorylaimida, Aporcelaimidae) from Vietnam
Fig. 1. Sectonema tropicum sp. nov. (Line). A. Lip region in lateral surface view. B. Anterior region in mid-optical level, lateral view. C. Neck region. D. ♀, anterior genital branch. E. Vagina. F. ♁, posterior body region. G. ♀, posterior body region. H. ♀, entire. I. ♁, entire. J. Lateral guiding piece. K. Spicule.
Fig. 6 in Two atypical new species of the genus Sectonema Thorne, 1930 (Nematoda, Dorylaimida, Aporcelaimidae) from Vietnam
Fig. 6. Maximum Likelihood tree as inferred from D2–D3 expansion segments of 28S rRNA gene sequence alignments under the GTR + I + G model. Bootstrap values are given for appropriate clades. Newly obtained sequences are indicated by bold letters.
Fig. 4 in Two atypical new species of the genus Sectonema Thorne, 1930 (Nematoda, Dorylaimida, Aporcelaimidae) from Vietnam
Fig. 4. Sectonema tropicum sp. nov. (SEM, ♁). A. Lip region in ventral view. B. Lip region in frontal view. C. Lip region in lateral view. D. Lip region in sublateral view. E. Posterior body region in ventral view. F. Posterior body region in lateral view. G. Caudal region in sublateral view. Scale bars: A–D = 5 μm; E–F = 20 μm; G = 10 μm
Artefacts for ICSE 2021 technical paper: "RAICC: Revealing Atypical Inter-Component Communication in Android Apps"
<p>This repository represents our artefacts to replicate our paper which is in the proceedings of ICSE 2021: "RAICC: Revealing Atypical Inter-Component Communication in Android Apps"</p>
Supplementary material to: Russian verbal aspect and the activation of event knowledge: Processing typical and atypical location adverbials in perfective and imperfective sentences
<p>Supplementary material for a self-paced reading experiment:</p> <ol> <li>Material: contains the verbal stimuli (experimental and filler sentences)</li> <li>raw_data.zip: E-Prime output for all 50 participants (tab-separated txt-files)</li> <li>spr_aspect_respinf.txt: Basic information on the participants; tab-separated txt-file</li> <li>spr_aspect_preprocessing_subm2_fin.R: data preprocessing and calculation of correct responses per speaker in R; R script<br>Input: <br>- Files from the "raw_data"-folder<br>- spr_aspect_respinf.txt<br>Output: <br>- spr_aspect_respinf_corr_resp.txt: same as spr_aspect_respinf.txt + number of correct responses per participant; tab-separated txt-file<br>- spr_aspect_all.txt: relevant data from all participants in one file; tab-separated txt-file<br>- spr_aspect_all_without-outlier.txt: same as spr_aspect_all.txt, but outliers set to NA; tab-separated txt-file</li> <li>spr_aspect_figures-stats_subm2_fin.R: plots figures and calculates statistics (descriptive statistics and GLMM) in R, R script<br>Input: <br>- spr_aspect_all_without-outlier.txt<br>Output:<br>- spr_aspect_avg.txt: Mean RT and SD per condition; tab-separated txt-file<br>- Figures</li> </ol>
Figure 3: Percentages of women in the non-atypical academic workforce in a subset of higher education institutions in the United Kingdom by institutional groupings, 2021
<p>This Zenodo entry includes the full data files (.csv and .xlsx) for Figure 3: <em>Percentages of women in the non-atypical academic workforce in a subset of higher education institutions in the United Kingdom by institutional groupings, 2021</em>', included in the manuscript "The Curtin Open Knowledge Initiative: Sharing data on scholarly research performance", authored by members of the Curtin Open Knowledge Initiative (COKI). The analysis is of publicly available data sourced from the United Kingdom Higher Education Statistics Agency (HESA).</p>
Fig. 1 in Discovery and successful development of Cuterebra americana (Diptera: Oestridae) from an atypical host, Rattus rattus (Rodentia: Muridae), in Florida, U.S.A.
Fig. 1. Puparium of Cuterebra americana (Fabricius), A) puparium in profile, 24 × 13 × 12 mm l × w × h; B) extruded, yellow, elliptical anterior spiracles with subtri- angular operculum on the tergum of segments 1 to 3; C) spines on surface of puparium; and D) magnified plate-like, multi-pointed spines. This figure is displayed in color in the online version of this article.
BRAIN Journal-Electrophysiological Neuroimaging using sLORETA Comparing 100 Schizophrenia Patients to 48 Patients with Major Depression -Figure 2. Resting State neuroimaging findings illustrating the action of atypical antipsychotics on postsynaptic dopamine D2
<p>Contrastingly, the results of the one-hundred males and females diagnosed with<br> Schizophrenia compared to the thirty-two females diagnosed with Major Depressive Disorder or<br> Depressive Episodes. The one-hundred male and female Schizophrenia patients had an average age<br> of 32-years-old and a Standard Deviation of 11.8-years. Whereas, the Depressive Episode and<br> Major Depressive Disorder females had an average age of 50-years old and a Standard Deviation of<br> 11.7-years. The statistically significant neuroimaging results identified the Delta (1.5–6 Hz)<br> frequency band at the neuroanatomical location of the region of the Superior Frontal Gyrus<br> (p=0.007; t=2.08, BA 10, X=25, Y=55, Z=30) with greater neuronal oscillations and synchrony in<br> the one-hundred males and females diagnosed with Schizophrenia than the thirty-two females<br> diagnosed with Depressive Episodes and Major Depressive Disorder.</p>
Figure 1 in Records of atypical pigmented bottlenose dolphins (Tursiops truncatus) at the south-western coast of the Black Sea (Zonguldak, Türkiye)
Figure 1. Sampling area and the sightings of unusually colored individuals of the bottlenose dolphin.
Figure 3 in Records of atypical pigmented bottlenose dolphins (Tursiops truncatus) at the south-western coast of the Black Sea (Zonguldak, Türkiye)
Figure 3. (a) Individuals of bottlenose dolphin with unusual coloration pattern recorded in the study area; (b) magnified images of their fins.
Figure 2 in Records of atypical pigmented bottlenose dolphins (Tursiops truncatus) at the south-western coast of the Black Sea (Zonguldak, Türkiye)
Figure 2. Image of a piebald female of bottlenose dolphin with an immature individual (a) and centered photograph of the dorsal fin (b).
Fig. 6 in An atypical Silurian myodocope ostracod from the Armorican Massif, France
Fig. 6. Measurements of Sineruga insolita gen. et sp. nov. Length−height plot of 39 specimens of S. insolita. Specimens comprise both latex casts from external moulds and 3−D preserved specimens. L, H as in Fig. 5. A = adults; A1–A6 = possible juvenile instars 1 to 6.
Fig. 5 in An atypical Silurian myodocope ostracod from the Armorican Massif, France
Fig. 5. Parameters used for measurements of Sineruga insolita gen. et sp. nov. H, maximum valve height; L, maximum valve length.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.